Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.11.23
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
[RNA-polymerase]-subunit kinase
2.7.12.1
Transferases;
Transferring phosphorus-containing groups;
Dual-specificity kinases (those acting on Ser/Thr and Tyr residues);
dual-specificity kinase
PDB | Resolution (Å) | PDB name |
---|---|---|
2VX3 | 2.4 | Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A |
2WO6 | 2.5 | Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in complex with a consensus substrate peptide |
3ANQ | 2.6 | human DYRK1A/inhibitor complex |
3ANR | 2.6 | human DYRK1A/harmine complex |
4AZE | 3.15 | Human DYRK1A in complex with Leucettine L41 |
4MQ1 | 2.35 | The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor |
4MQ2 | 2.8 | The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor |
4NCT | 2.597 | Human DYRK1A in complex with PKC412 |
4YLJ | 2.58 | Crystal structure of DYRK1A in complex with 10-Iodo-substituted 11H-indolo[3,2-c]quinoline-6-carboxylic acid inhibitor 5j |
4YLK | 1.4 | Crystal structure of DYRK1A in complex with 10-Chloro-substituted 11H-indolo[3,2-c]quinolone-6-carboxylic acid inhibitor 5s |
4YLL | 1.4 | Crystal structure of DYRK1AA in complex with 10-Bromo-substituted 11H-indolo[3,2-c]quinolone-6-carboxylic acid inhibitor 5t |
4YU2 | 2.9 | Crystal structure of DYRK1A with harmine-derivatized AnnH-75 inhibitor |
5A3X | 2.26 | DYRK1A in complex with hydroxy benzothiazole fragment |
5A4E | 2.68 | DYRK1A in complex with methoxy benzothiazole fragment |
5A4L | 2.73 | DYRK1A IN COMPLEX WITH FLUORO BENZOTHIAZOLE FRAGMENT |
5A4Q | 2.37 | DYRK1A IN COMPLEX WITH CHLORO BENZOTHIAZOLE FRAGMENT |
5A4T | 2.15 | DYRK1A IN COMPLEX WITH NITRILE BENZOTHIAZOLE FRAGMENT |
5A54 | 2.63 | DYRK1A IN COMPLEX WITH NITRO BENZOTHIAZOLE FRAGMENT |
5AIK | 2.7 | Human DYRK1A in complex with LDN-211898 |
6A1F | 1.5 | Crystal structure of human DYRK1A in complex with compound 14 |
6A1G | 2.15 | Crystal structure of human DYRK1A in complex with compound 32 |
6EIF | 2.22 | DYRK1A in complex with XMD7-117 |
6EIJ | 2.42 | DYRK1A in complex with HG-8-60-1 |
6EIL | 2.465 | DYRK1A in complex with XMD8-49 |
6EIP | 2.56 | DYRK1A in complex with XMD8-62e |
6EIQ | 2.3 | DYRK1A in complex with XMD14-124 |
6EIR | 2.4 | DYRK1A in complex with XMD15-27-2 |
6EIS | 2.36 | DYRK1A in complex with JWC-055 |
6EIV | 2.68 | DYRK1A in complex with JWD-065 |
6EJ4 | 2.88 | DYRK1A in complex with XMD7-112 |
6LN1 | 2.699 | A natural inhibitor of DYRK1A for treatment of diabetes mellitus |
6QU2 | 2.9 | Crystal structure of DYRK1A complexed with FC162 inhibitor |
6S11 | 2.445 | Crystal Structure of DYRK1A with small molecule inhibitor |
6S14 | 1.05 | Crystal Structure of DYRK1A with small molecule inhibitor |
6S17 | 1.1 | Crystal Structure of DYRK1A with small molecule inhibitor |
6S1B | 1.3 | Crystal Structure of DYRK1A with small molecule inhibitor |
6S1H | 1.05 | Crystal Structure of DYRK1A with small molecule inhibitor |
6S1I | 2.38 | Crystal Structure of DYRK1A with small molecule inhibitor |
6S1J | 1.408 | Crystal Structure of DYRK1A with small molecule inhibitor |
6T6A | 2.8 | Crystal structure of DYRK1A complexed with KuFal319 (compound 11) |
6UIP | 3.7 | DYRK1A Kinase Domain in Complex with a 6-azaindole Derivative, GNF2133. |
6UWY | 2.95 | DYRK1A bound to a harmine derivative |
6YF8 | 3.198 | DYRK1A with PST001 |
7A4O | 1.9 | Structure of DYRK1A in complex with AMPNP |
7A4R | 1.8 | Structure of DYRK1A in complex with compound 1 |
7A4S | 3.1 | Structure of DYRK1A in complex with compound 2 |
7A4W | 2.7 | Structure of DYRK1A in complex with compound 3 |
7A4Z | 1.9 | Structure of DYRK1A in complex with compound 4 |
7A51 | 1.9 | Structure of DYRK1A in complex with compound 5 |
7A52 | 2.1 | Structure of DYRK1A in complex with compound 6 |
7A53 | 2.2 | Structure of DYRK1A in complex with compound 7 |
7A55 | 2.2 | Structure of DYRK1A in complex with compound 8 |
7A5B | 2.6 | Structure of DYRK1A in complex with complex 10 |
7A5D | 1.8 | Structure of DYRK1A in complex with compound 16 |
7A5L | 2.1 | tructure of DYRK1A in complex with compound 24 |
7A5N | 2.3 | Structure of DYRK1A in complex with compound 34 |
7AJ2 | 2.1 | Structure of DYRK1A in complex with compound 3 |
7AJ4 | 2.0 | Structure of DYRK1A in complex with compound 5 |
7AJ5 | 2.0 | Structure of DYRK1A in complex with compound 10 |
7AJ7 | 2.9 | Structure of DYRK1A in complex with compound 16 |
7AJ8 | 2.0 | Structure of DYRK1A in complex with compound 25 |
7AJA | 2.2 | Structure of DYRK1A in complex with compound 28 |
7AJM | 2.4 | Structure of DYRK1A in complex with compound 32 |
7AJS | 2.15 | Structure of DYRK1A in complex with compound 33 |
7AJV | 2.1 | Structure of DYRK1A in complex with compound 38 |
7AJW | 2.8 | Structure of DYRK1A in complex with compound 46 |
7AJY | 2.2 | Structure of DYRK1A in complex with compound 51 |
7AK2 | 2.1 | Structure of DYRK1A in complex with compound 53 |
7AKA | 1.9 | Structure of DYRK1A in complex with compound 54 |
7AKB | 2.8 | Structure of DYRK1A in complex with compound 56 |
7AKE | 2.3 | Structure of DYRK1A in complex with compound 58 |
7AKL | 2.0 | Structure of DYRK1A in complex with compound 50 |
7FHS | 2.42 | Crystal structure of DYRK1A in complex with RD0392 |
7FHT | 2.68 | Crystal structure of DYRK1A in complex with RD0448 |
7O7K | 1.82 | Crystal structure of the human DYRK1A kinase domain bound to abemaciclib |
7OY6 | 2.38 | Crystal structure of human DYRK1A in complex with ARN25068 |
7Z5N | 2.77 | Crystal structure of DYRK1A in complex with CX-4945 |
7ZH8 | 2.3 | DYRK1a in Complex with a Bromo-Triazolo-Pyridine |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0034205 | amyloid-beta formation |
Biological Process | GO:0007623 | circadian rhythm |
Biological Process | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
Biological Process | GO:0090310 | negative regulation of DNA methylation-dependent heterochromatin formation |
Biological Process | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
Biological Process | GO:0031115 | negative regulation of microtubule polymerization |
Biological Process | GO:0007399 | nervous system development |
Biological Process | GO:0036289 | peptidyl-serine autophosphorylation |
Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
Biological Process | GO:0018107 | peptidyl-threonine phosphorylation |
Biological Process | GO:0038083 | peptidyl-tyrosine autophosphorylation |
Biological Process | GO:0018108 | peptidyl-tyrosine phosphorylation |
Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
Biological Process | GO:0033120 | positive regulation of RNA splicing |
Biological Process | GO:0090312 | positive regulation of protein deacetylation |
Biological Process | GO:0046777 | protein autophosphorylation |
Biological Process | GO:0006468 | protein phosphorylation |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity |
Molecular Function | GO:0003779 | actin binding |
Molecular Function | GO:0008092 | cytoskeletal protein binding |
Molecular Function | GO:0140857 | histone H3T45 kinase activity |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
Molecular Function | GO:0004672 | protein kinase activity |
Molecular Function | GO:0043621 | protein self-association |
Molecular Function | GO:0106310 | protein serine kinase activity |
Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
Molecular Function | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
Molecular Function | GO:0004713 | protein tyrosine kinase activity |
Molecular Function | GO:0048156 | tau protein binding |
Molecular Function | GO:0050321 | tau-protein kinase activity |
Molecular Function | GO:0003713 | transcription coactivator activity |
Molecular Function | GO:0015631 | tubulin binding |
Cellular Component | GO:0030424 | axon |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005856 | cytoskeleton |
Cellular Component | GO:0030425 | dendrite |
Cellular Component | GO:0016607 | nuclear speck |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:1990904 | ribonucleoprotein complex |
InterPro | InterPro name |
---|---|
IPR000719 | Protein kinase domain |
IPR008271 | Serine/threonine-protein kinase, active site |
IPR011009 | Protein kinase-like domain superfamily |
IPR017441 | Protein kinase, ATP binding site |
IPR044131 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain |
Pfam | Pfam name |
---|---|
PF00069 | Protein kinase domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-1538133 | G0 and Early G1 | Internal node | R-HSA-1640170 | Cell Cycle |
Location | ECO term | Pubmed |
---|---|---|
Nucleus | ECO:0000269 | PubMed:20167603 |
Nucleus | ECO:0000269 | PubMed:23415227 |
Nucleus | ECO:0000269 | PubMed:25620562 |
Nucleus speckle | ECO:0000250 |
HPO ID | HPO name |
---|---|
HP:0000006 | Autosomal dominant inheritance |
HP:0000010 | Recurrent urinary tract infections |
HP:0000023 | Inguinal hernia |
HP:0000028 | Cryptorchidism |
HP:0000041 | Chordee |
HP:0000047 | Hypospadias |
HP:0000049 | Shawl scrotum |
HP:0000054 | Micropenis |
HP:0000107 | Renal cyst |
HP:0000119 | Abnormality of the genitourinary system |
HP:0000122 | Unilateral renal agenesis |
HP:0000125 | Pelvic kidney |
HP:0000126 | Hydronephrosis |
HP:0000179 | Thick lower lip vermilion |
HP:0000185 | Cleft soft palate |
HP:0000219 | Thin upper lip vermilion |
HP:0000252 | Microcephaly |
HP:0000278 | Retrognathia |
HP:0000319 | Smooth philtrum |
HP:0000341 | Narrow forehead |
HP:0000347 | Micrognathia |
HP:0000365 | Hearing impairment |
HP:0000377 | Abnormal pinna morphology |
HP:0000391 | Thickened helices |
HP:0000400 | Macrotia |
HP:0000411 | Protruding ear |
HP:0000414 | Bulbous nose |
HP:0000426 | Prominent nasal bridge |
HP:0000430 | Underdeveloped nasal alae |
HP:0000455 | Broad nasal tip |
HP:0000478 | Abnormality of the eye |
HP:0000483 | Astigmatism |
HP:0000486 | Strabismus |
HP:0000490 | Deeply set eye |
HP:0000504 | Abnormality of vision |
HP:0000518 | Cataract |
HP:0000540 | Hypermetropia |
HP:0000541 | Retinal detachment |
HP:0000543 | Optic disc pallor |
HP:0000545 | Myopia |
HP:0000565 | Esotropia |
HP:0000577 | Exotropia |
HP:0000582 | Upslanted palpebral fissure |
HP:0000601 | Hypotelorism |
HP:0000612 | Iris coloboma |
HP:0000646 | Amblyopia |
HP:0000687 | Widely spaced teeth |
HP:0000708 | Atypical behavior |
HP:0000717 | Autism |
HP:0000718 | Aggressive behavior |
HP:0000729 | Autistic behavior |
HP:0000733 | Abnormal repetitive mannerisms |
HP:0000739 | Anxiety |
HP:0000748 | Inappropriate laughter |
HP:0000750 | Delayed speech and language development |
HP:0000752 | Hyperactivity |
HP:0000767 | Pectus excavatum |
HP:0000818 | Abnormality of the endocrine system |
HP:0000821 | Hypothyroidism |
HP:0000824 | Decreased response to growth hormone stimulation test |
HP:0000960 | Sacral dimple |
HP:0001182 | Tapered finger |
HP:0001249 | Intellectual disability |
HP:0001250 | Seizure |
HP:0001251 | Ataxia |
HP:0001256 | Intellectual disability, mild |
HP:0001263 | Global developmental delay |
HP:0001270 | Motor delay |
HP:0001276 | Hypertonia |
HP:0001288 | Gait disturbance |
HP:0001290 | Generalized hypotonia |
HP:0001344 | Absent speech |
HP:0001508 | Failure to thrive |
HP:0001511 | Intrauterine growth retardation |
HP:0001518 | Small for gestational age |
HP:0001531 | Failure to thrive in infancy |
HP:0001561 | Polyhydramnios |
HP:0001562 | Oligohydramnios |
HP:0001627 | Abnormal heart morphology |
HP:0001629 | Ventricular septal defect |
HP:0001641 | Abnormal pulmonary valve morphology |
HP:0001643 | Patent ductus arteriosus |
HP:0001650 | Aortic valve stenosis |
HP:0001659 | Aortic regurgitation |
HP:0001760 | Abnormal foot morphology |
HP:0001773 | Short foot |
HP:0001780 | Abnormal toe morphology |
HP:0001822 | Hallux valgus |
HP:0001831 | Short toe |
HP:0001999 | Abnormal facial shape |
HP:0002013 | Vomiting |
HP:0002015 | Dysphagia |
HP:0002019 | Constipation |
HP:0002020 | Gastroesophageal reflux |
HP:0002021 | Pyloric stenosis |
HP:0002033 | Poor suck |
HP:0002069 | Bilateral tonic-clonic seizure |
HP:0002079 | Hypoplasia of the corpus callosum |
HP:0002119 | Ventriculomegaly |
HP:0002120 | Cerebral cortical atrophy |
HP:0002123 | Generalized myoclonic seizure |
HP:0002136 | Broad-based gait |
HP:0002171 | Gliosis |
HP:0002247 | Duodenal atresia |
HP:0002269 | Abnormality of neuronal migration |
HP:0002311 | Incoordination |
HP:0002360 | Sleep disturbance |
HP:0002363 | Abnormal brainstem morphology |
HP:0002365 | Hypoplasia of the brainstem |
HP:0002373 | Febrile seizure (within the age range of 3 months to 6 years) |
HP:0002465 | Poor speech |
HP:0002650 | Scoliosis |
HP:0002719 | Recurrent infections |
HP:0002808 | Kyphosis |
HP:0003196 | Short nose |
HP:0003319 | Abnormality of the cervical spine |
HP:0003429 | CNS hypomyelination |
HP:0003561 | Birth length less than 3rd percentile |
HP:0003577 | Congenital onset |
HP:0003593 | Infantile onset |
HP:0004322 | Short stature |
HP:0005768 | 2-4 toe cutaneous syndactyly |
HP:0006466 | Ankle flexion contracture |
HP:0007018 | Attention deficit hyperactivity disorder |
HP:0007957 | Corneal opacity |
HP:0008872 | Feeding difficulties in infancy |
HP:0009121 | Abnormal axial skeleton morphology |
HP:0010314 | Premature thelarche |
HP:0010442 | Polydactyly |
HP:0010819 | Atonic seizure |
HP:0010864 | Intellectual disability, severe |
HP:0010946 | Dilatation of the renal pelvis |
HP:0011069 | Supernumerary tooth |
HP:0011147 | Typical absence seizure |
HP:0011171 | Simple febrile seizure |
HP:0011344 | Severe global developmental delay |
HP:0011470 | Nasogastric tube feeding in infancy |
HP:0011757 | Posterior pituitary hypoplasia |
HP:0011822 | Broad chin |
HP:0011917 | Short 5th toe |
HP:0011968 | Feeding difficulties |
HP:0012171 | Stereotypical hand wringing |
HP:0012785 | Flexion contracture of finger |
HP:0025163 | Abnormality of optic chiasm morphology |
HP:0040082 | Happy demeanor |
HP:0040188 | Osteochondrosis |
HP:0100783 | Breast aplasia |
HP:0410263 | Brain imaging abnormality |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
intellectual disability syndrome due to a dyrk1a point mutation | MONDO:0018733 | Q87 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | Orphanet:464311 |