Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.14.11.-
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor;
1.14.11.33
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor;
DNA oxidative demethylase
1.14.11.51
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor;
DNA N6-methyladenine demethylase
4.2.99.18
Lyases;
Carbon-oxygen lyases;
Other carbon-oxygen lyases;
DNA-(apurinic or apyrimidinic site) lyase
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006307 | DNA dealkylation involved in DNA repair |
Biological Process | GO:0080111 | DNA demethylation |
Biological Process | GO:0006281 | DNA repair |
Biological Process | GO:0042245 | RNA repair |
Biological Process | GO:0048589 | developmental growth |
Biological Process | GO:0001701 | in utero embryonic development |
Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
Biological Process | GO:0001764 | neuron migration |
Biological Process | GO:0031175 | neuron projection development |
Biological Process | GO:0035513 | oxidative RNA demethylation |
Biological Process | GO:0070989 | oxidative demethylation |
Biological Process | GO:0035552 | oxidative single-stranded DNA demethylation |
Biological Process | GO:0001890 | placenta development |
Biological Process | GO:0070129 | regulation of mitochondrial translation |
Biological Process | GO:0006448 | regulation of translational elongation |
Biological Process | GO:0006446 | regulation of translational initiation |
Biological Process | GO:1990983 | tRNA demethylation |
Biological Process | GO:0002101 | tRNA wobble cytosine modification |
Molecular Function | GO:0016706 | 2-oxoglutarate-dependent dioxygenase activity |
Molecular Function | GO:0042056 | chemoattractant activity |
Molecular Function | GO:0140078 | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
Molecular Function | GO:0008198 | ferrous iron binding |
Molecular Function | GO:0070579 | methylcytosine dioxygenase activity |
Molecular Function | GO:0035516 | oxidative DNA demethylase activity |
Molecular Function | GO:0035515 | oxidative RNA demethylase activity |
Molecular Function | GO:0000049 | tRNA binding |
Molecular Function | GO:1990984 | tRNA demethylase activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005783 | endoplasmic reticulum |
Cellular Component | GO:0000791 | euchromatin |
Cellular Component | GO:0005739 | mitochondrion |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
InterPro | InterPro name |
---|---|
IPR004574 | Alkylated DNA repair protein AlkB |
IPR005123 | Oxoglutarate/iron-dependent dioxygenase |
IPR027450 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
IPR037151 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily |
Pfam | Pfam name |
---|---|
PF13532 | 2OG-Fe(II) oxygenase superfamily |
Location | ECO term | Pubmed |
---|---|---|
Mitochondrion | ECO:0000269 | PubMed:17979886 |
Mitochondrion | ECO:0000269 | PubMed:18603530 |
Mitochondrion | ECO:0000269 | PubMed:27497299 |
Nucleus | ECO:0000269 | PubMed:22961808 |