MultifacetedProtDB - Bologna Biocomputing Group

PDB	Resolution (Å)	PDB name
1XM9	2.8	Structure of the armadillo repeat domain of plakophilin 1

GO ontology	GO term	GO description
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0007043	cell-cell junction assembly
Biological Process	GO:0045110	intermediate filament bundle assembly
Biological Process	GO:1902373	negative regulation of mRNA catabolic process
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0007165	signal transduction
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0019215	intermediate filament binding
Molecular Function	GO:0005521	lamin binding
Molecular Function	GO:0030280	structural constituent of skin epidermis
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0001533	cornified envelope
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030057	desmosome
Cellular Component	GO:0101003	ficolin-1-rich granule membrane
Cellular Component	GO:0005882	intermediate filament
Cellular Component	GO:1990124	messenger ribonucleoprotein complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane

Pfam	Pfam name
PF00514	Armadillo/beta-catenin-like repeat

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System
R-HSA-6805567	Keratinization	Internal node	R-HSA-1266738	Developmental Biology
R-HSA-6809371	Formation of the cornified envelope	Leaf	R-HSA-1266738	Developmental Biology

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000164	Abnormality of the dentition
HP:0000561	Absent eyelashes
HP:0000670	Carious teeth
HP:0000966	Hypohidrosis
HP:0000968	Ectodermal dysplasia
HP:0000970	Anhidrosis
HP:0000972	Palmoplantar hyperkeratosis
HP:0000982	Palmoplantar keratoderma
HP:0000989	Pruritus
HP:0001030	Fragile skin
HP:0001508	Failure to thrive
HP:0001581	Recurrent skin infections
HP:0002028	Chronic diarrhea
HP:0002223	Absent eyebrow
HP:0002289	Alopecia universalis
HP:0002293	Alopecia of scalp
HP:0002355	Difficulty walking
HP:0003577	Congenital onset
HP:0004322	Short stature
HP:0005218	Anoperineal fistula
HP:0006482	Abnormality of dental morphology
HP:0006532	Recurrent pneumonia
HP:0007446	Palmoplantar blistering
HP:0007502	Follicular hyperkeratosis
HP:0008066	Abnormal blistering of the skin
HP:0008070	Sparse hair
HP:0008391	Dystrophic fingernails
HP:0008404	Nail dystrophy
HP:0012227	Urethral stricture
HP:0030809	Abnormal tongue morphology
HP:0040181	Chapped lip
HP:0040189	Scaling skin
HP:0100699	Scarring
HP:0100806	Sepsis
HP:0100825	Cheilitis

Tissue	Cell type	Expression level	Reliability
breast	myoepithelial cells	Low	Enhanced
cerebral cortex	endothelial cells	Medium	Enhanced
cervix	squamous epithelial cells	High	Enhanced
esophagus	squamous epithelial cells	Medium	Enhanced
oral mucosa	squamous epithelial cells	Medium	Enhanced
skin 1	cells in basal layer	Medium	Enhanced
skin 1	cells in granular layer	Medium	Enhanced
skin 1	cells in spinous layer	Medium	Enhanced
skin 1	endothelial cells	Low	Enhanced
skin 1	hair follicles	Medium	Enhanced
skin 1	langerhans cells	Medium	Enhanced
skin 1	melanocytes	Medium	Enhanced
skin 1	sebaceous glands	Medium	Enhanced
skin 2	cells in basal layer	Medium	Enhanced
skin 2	cells in granular layer	Medium	Enhanced
skin 2	cells in spinous layer	Medium	Enhanced
skin 2	endothelial cells	Low	Enhanced
skin 2	langerhans cells	Medium	Enhanced
skin 2	melanocytes	Medium	Enhanced
tonsil	squamous epithelial cells	Low	Enhanced
vagina	squamous epithelial cells	Medium	Enhanced