MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1CL3		MOLECULAR INSIGHTS INTO PEBP2/CBF-SMMHC ASSOCIATED ACUTE LEUKEMIA REVEALED FROM THE THREE-DIMENSIONAL STRUCTURE OF PEBP2/CBF BETA
1E50	2.6	AML1/CBFbeta complex
1H9D	2.6	Aml1/cbf-beta/dna complex
4N9F	3.3	Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex
6NIL	3.9	cryoEM structure of the truncated HIV-1 Vif/CBFbeta/A3F complex
6P59	2.94221	Crystal structure of SIVrcm Vif-CBFbeta-ELOB-ELOC complex
6VGD	4.2	Crystal structure of the DNA binding domain (DBD) of human FLI1 and the complex of the DBD of human Runx2 with core binding factor beta (Cbfb), in complex with 16mer DNA CAGAGGATGTGGCTTC
6VGE	4.25	Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), in complex with 16mer DNA CAGAGGATGTGGCTTC
6VGG	4.31	Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC
8CX0	2.7	Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex
8CX1	3.3	Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1
8CX2	3.2	Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2
8E40	3.57	Full-length APOBEC3G in complex with HIV-1 Vif, CBF-beta, and fork RNA

GO term

GO ontology	GO term	GO description
Biological Process	GO:0048469	cell maturation
Biological Process	GO:0060216	definitive hemopoiesis
Biological Process	GO:0030098	lymphocyte differentiation
Biological Process	GO:0030099	myeloid cell differentiation
Biological Process	GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0001649	osteoblast differentiation
Biological Process	GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0000209	protein polyubiquitination
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0006366	transcription by RNA polymerase II
Molecular Function	GO:0043565	sequence-specific DNA binding
Molecular Function	GO:0003713	transcription coactivator activity
Cellular Component	GO:0016513	core-binding factor complex
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005654	nucleoplasm

InterPro / Pfam

InterPro	InterPro name
IPR003417	Core-binding factor, beta subunit
IPR036552	Core-binding factor, beta subunit superfamily

Pfam	Pfam name
PF02312	Core binding factor beta subunit

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8878166	Transcriptional regulation by RUNX2	Internal node	R-HSA-74160	Gene expression (Transcription)
R-HSA-8931987	RUNX1 regulates estrogen receptor mediated transcription	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8934593	Regulation of RUNX1 Expression and Activity	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8939245	RUNX1 regulates transcription of genes involved in BCR signaling	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8939902	Regulation of RUNX2 expression and activity	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8941284	RUNX2 regulates chondrocyte maturation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8941326	RUNX2 regulates bone development	Internal node	R-HSA-74160	Gene expression (Transcription)
R-HSA-8941332	RUNX2 regulates genes involved in cell migration	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8941858	Regulation of RUNX3 expression and activity	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8949275	RUNX3 Regulates Immune Response and Cell Migration	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8951911	RUNX3 regulates RUNX1-mediated transcription	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8951936	RUNX3 regulates p14-ARF	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9018519	Estrogen-dependent gene expression	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9616222	Transcriptional regulation of granulopoiesis	Leaf	R-HSA-1266738	Developmental Biology

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000260	Wide anterior fontanel
HP:0000307	Pointed chin
HP:0000327	Hypoplasia of the maxilla
HP:0000365	Hearing impairment
HP:0000680	Delayed eruption of primary teeth
HP:0000894	Short clavicles
HP:0000938	Osteopenia
HP:0001216	Delayed ossification of carpal bones
HP:0001263	Global developmental delay
HP:0001357	Plagiocephaly
HP:0001508	Failure to thrive
HP:0001763	Pes planus
HP:0002673	Coxa valga
HP:0002857	Genu valgum
HP:0003577	Congenital onset
HP:0003621	Juvenile onset
HP:0006585	Congenital pseudoarthrosis of the clavicle
HP:0006660	Aplastic clavicle
HP:0008788	Delayed pubic bone ossification
HP:0009882	Short distal phalanx of finger
HP:0011069	Supernumerary tooth
HP:0011220	Prominent forehead
HP:0011304	Broad thumb
HP:0011462	Young adult onset
HP:0011463	Childhood onset
HP:0200021	Down-sloping shoulders

Summary of Q13951

Gene: CBFB
Protein: Core-binding factor subunit beta

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q13951

Gene: CBFB Protein: Core-binding factor subunit beta

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CBFB
Protein: Core-binding factor subunit beta