MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.11.22	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; cyclin-dependent kinase
2.7.11.23	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; [RNA-polymerase]-subunit kinase

Structure

PDB	Resolution (Å)	PDB name
5EFQ	2.0	Crystal structure of human Cdk13/Cyclin K in complex with ADP-aluminum fluoride
7NXJ	2.36	Crystal structure of human Cdk13/Cyclin K in complex with the inhibitor THZ531

GO term

GO ontology	GO term	GO description
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome
Biological Process	GO:0030097	hemopoiesis
Biological Process	GO:2000737	negative regulation of stem cell differentiation
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0009966	regulation of signal transduction
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity
Molecular Function	GO:0030332	cyclin binding
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
Molecular Function	GO:0004672	protein kinase activity
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0106310	protein serine kinase activity
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0002945	cyclin K-CDK13 complex
Cellular Component	GO:0008024	cyclin/CDK positive transcription elongation factor complex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:1904813	ficolin-1-rich granule lumen
Cellular Component	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus

InterPro / Pfam

InterPro	InterPro name
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Pfam	Pfam name
PF00069	Protein kinase domain
PF12330	Haspin like kinase domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System

Subcellular location

Location	ECO term	Pubmed
Nucleus speckle	ECO:0000269	PubMed:16721827

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000160	Narrow mouth
HP:0000200	Short lingual frenulum
HP:0000215	Thick upper lip vermilion
HP:0000219	Thin upper lip vermilion
HP:0000233	Thin vermilion border
HP:0000252	Microcephaly
HP:0000269	Prominent occiput
HP:0000286	Epicanthus
HP:0000316	Hypertelorism
HP:0000319	Smooth philtrum
HP:0000322	Short philtrum
HP:0000324	Facial asymmetry
HP:0000356	Abnormality of the outer ear
HP:0000358	Posteriorly rotated ears
HP:0000369	Low-set ears
HP:0000396	Overfolded helix
HP:0000414	Bulbous nose
HP:0000426	Prominent nasal bridge
HP:0000431	Wide nasal bridge
HP:0000486	Strabismus
HP:0000506	Telecanthus
HP:0000508	Ptosis
HP:0000574	Thick eyebrow
HP:0000581	Blepharophimosis
HP:0000582	Upslanted palpebral fissure
HP:0000691	Microdontia
HP:0000717	Autism
HP:0000750	Delayed speech and language development
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001252	Hypotonia
HP:0001263	Global developmental delay
HP:0001270	Motor delay
HP:0001274	Agenesis of corpus callosum
HP:0001357	Plagiocephaly
HP:0001382	Joint hypermobility
HP:0001511	Intrauterine growth retardation
HP:0001561	Polyhydramnios
HP:0001629	Ventricular septal defect
HP:0001631	Atrial septal defect
HP:0002019	Constipation
HP:0002020	Gastroesophageal reflux
HP:0002079	Hypoplasia of the corpus callosum
HP:0002121	Generalized non-motor (absence) seizure
HP:0002162	Low posterior hairline
HP:0002212	Curly hair
HP:0002472	Small cerebral cortex
HP:0002553	Highly arched eyebrow
HP:0002572	Episodic vomiting
HP:0002650	Scoliosis
HP:0002714	Downturned corners of mouth
HP:0003298	Spina bifida occulta
HP:0003577	Congenital onset
HP:0004322	Short stature
HP:0005989	Redundant neck skin
HP:0006610	Wide intermamillary distance
HP:0006970	Periventricular leukomalacia
HP:0007413	Nevus flammeus of the forehead
HP:0010536	Central sleep apnea
HP:0011856	Pica
HP:0011968	Feeding difficulties
HP:0012385	Camptodactyly
HP:0012745	Short palpebral fissure
HP:0025336	Delayed ability to sit
HP:0030084	Clinodactyly
HP:0031936	Delayed ability to walk

Tissue and cell type

Disease

Summary of Q14004

Gene: CDK13, CDC2L, CDC2L5, CHED, KIAA1791
Protein: Cyclin-dependent kinase 13

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q14004

Gene: CDK13, CDC2L, CDC2L5, CHED, KIAA1791 Protein: Cyclin-dependent kinase 13

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CDK13, CDC2L, CDC2L5, CHED, KIAA1791
Protein: Cyclin-dependent kinase 13