Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
3J8B | 9.3 | Model of the human eIF3 PCI-MPN octamer docked into the 43S-HCV IRES EM map |
3J8C | 11.6 | Model of the human eIF3 PCI-MPN octamer docked into the 43S EM map |
6YBD | 3.3 | Structure of a human 48S translational initiation complex - eIF3 |
6YBT | 6.0 | Structure of a human 48S translational initiation complex - eIF3bgi |
6ZMW | 3.7 | Structure of a human 48S translational initiation complex |
6ZON | 3.0 | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 |
6ZP4 | 2.9 | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2 |
6ZVJ | 3.8 | Structure of a human ABCE1-bound 43S pre-initiation complex - State II |
7A09 | 3.5 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III |
7QP6 | 4.7 | Structure of the human 48S initiation complex in open state (h48S AUG open) |
7QP7 | 3.7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0075522 | IRES-dependent viral translational initiation |
Biological Process | GO:0001732 | formation of cytoplasmic translation initiation complex |
Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
Biological Process | GO:0002188 | translation reinitiation |
Biological Process | GO:0006413 | translational initiation |
Biological Process | GO:0075525 | viral translational termination-reinitiation |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0003729 | mRNA binding |
Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
Molecular Function | GO:0005198 | structural molecule activity |
Molecular Function | GO:0003743 | translation initiation factor activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0016282 | eukaryotic 43S preinitiation complex |
Cellular Component | GO:0033290 | eukaryotic 48S preinitiation complex |
Cellular Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
Cellular Component | GO:0071540 | eukaryotic translation initiation factor 3 complex, eIF3e |
Cellular Component | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005874 | microtubule |
Cellular Component | GO:0043614 | multi-eIF complex |
Cellular Component | GO:0005730 | nucleolus |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0014069 | postsynaptic density |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72649 | Translation initiation complex formation | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72689 | Formation of a pool of free 40S subunits | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72702 | Ribosomal scanning and start codon recognition | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | Leaf | R-HSA-392499 | Metabolism of proteins |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000255 | PubMed:9150439 |