MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.10.2	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases; non-specific protein-tyrosine kinase

Structure

PDB	Resolution (Å)	PDB name
2LK4		Structural and mechanistic insights into the interaction between PAT Pyk2 and Paxillin LD motif
3CC6	1.6	Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B)
3ET7	2.7	Crystal structure of PYK2 complexed with PF-2318841
3FZO	2.2	Crystal Structure of PYK2-Apo, Proline-rich Tyrosine Kinase
3FZP	2.1	Crystal structure of PYK2 complexed with ATPgS
3FZR	2.7	Crystal structure of PYK2 complexed with PF-431396
3FZS	1.75	Crystal Structure of PYK2 complexed with BIRB796
3FZT	1.95	Crystal structure of PYK2 complexed with PF-4618433
3GM1	2.95	Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 in Complex with Paxillin LD4 Motif-Derived Peptides
3GM2	2.71	Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2
3GM3	2.6	Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2
3H3C	2.0	Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog
3U3F	3.101	Structural basis for the interaction of Pyk2 PAT domain with paxillin LD motifs
4EKU	3.25	Crystal Structure of FERM Domain of Proline-rich Tyrosine Kinase 2
4H1J	2.0	Crystal structure of PYK2 with the pyrazole 13a
4H1M	1.99	Crystal structure of PYK2 with the indole 10c
4R32	3.505	Crystal Structure Analysis of Pyk2 and Paxillin LD motifs
4XEF	2.5	Pyk2-FAT complexed with Leupaxin LD motif LD1
4XEK	1.793	Pyk2-FAT domain in complex with leupaxin LD4 motif
4XEV	2.0073	Fusion of Pyk2-FAT domain with Leupaxin LD1 motif, complexed with Leupaxin LD4 peptide
5TO8	1.9849	Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
5TOB	2.117	Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
6LF3	3.2	3D domain-swapped dimer of the maltose-binding protein fused to a fragment of the protein-tyrosine kinase 2-beta
7PLL		Structure of the murine cortactin C-SH3 domain in complex with a Pyk2 proline-rich ligand

GO term

GO ontology	GO term	GO description
Biological Process	GO:0000165	MAPK cascade
Biological Process	GO:0090630	activation of GTPase activity
Biological Process	GO:0042976	activation of Janus kinase activity
Biological Process	GO:0002250	adaptive immune response
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0043534	blood vessel endothelial cell migration
Biological Process	GO:0045453	bone resorption
Biological Process	GO:0007166	cell surface receptor signaling pathway
Biological Process	GO:0006968	cellular defense response
Biological Process	GO:0071498	cellular response to fluid shear stress
Biological Process	GO:0071300	cellular response to retinoic acid
Biological Process	GO:0070098	chemokine-mediated signaling pathway
Biological Process	GO:0086100	endothelin receptor signaling pathway
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway
Biological Process	GO:0048041	focal adhesion assembly
Biological Process	GO:0014009	glial cell proliferation
Biological Process	GO:0007229	integrin-mediated signaling pathway
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway
Biological Process	GO:0060292	long-term synaptic depression
Biological Process	GO:0060291	long-term synaptic potentiation
Biological Process	GO:0002315	marginal zone B cell differentiation
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0030502	negative regulation of bone mineralization
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation
Biological Process	GO:0043524	negative regulation of neuron apoptotic process
Biological Process	GO:0043267	negative regulation of potassium ion transport
Biological Process	GO:0031175	neuron projection development
Biological Process	GO:0001556	oocyte maturation
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation
Biological Process	GO:2000538	positive regulation of B cell chemotaxis
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0046330	positive regulation of JNK cascade
Biological Process	GO:0043507	positive regulation of JUN kinase activity
Biological Process	GO:0030838	positive regulation of actin filament polymerization
Biological Process	GO:0045766	positive regulation of angiogenesis
Biological Process	GO:0030307	positive regulation of cell growth
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration
Biological Process	GO:0010595	positive regulation of endothelial cell migration
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential
Biological Process	GO:0010976	positive regulation of neuron projection development
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
Biological Process	GO:0045860	positive regulation of protein kinase activity
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic
Biological Process	GO:0045727	positive regulation of translation
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission
Biological Process	GO:0046777	protein autophosphorylation
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0065003	protein-containing complex assembly
Biological Process	GO:2000310	regulation of NMDA receptor activity
Biological Process	GO:0032956	regulation of actin cytoskeleton organization
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization
Biological Process	GO:0010752	regulation of cGMP-mediated signaling
Biological Process	GO:0050848	regulation of calcium-mediated signaling
Biological Process	GO:0030155	regulation of cell adhesion
Biological Process	GO:0008360	regulation of cell shape
Biological Process	GO:2000114	regulation of establishment of cell polarity
Biological Process	GO:0032960	regulation of inositol trisphosphate biosynthetic process
Biological Process	GO:0010758	regulation of macrophage chemotaxis
Biological Process	GO:0099151	regulation of postsynaptic density assembly
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol
Biological Process	GO:0048167	regulation of synaptic plasticity
Biological Process	GO:2000058	regulation of ubiquitin-dependent protein catabolic process
Biological Process	GO:0051591	response to cAMP
Biological Process	GO:0051592	response to calcium ion
Biological Process	GO:0043157	response to cation stress
Biological Process	GO:0042220	response to cocaine
Biological Process	GO:0045471	response to ethanol
Biological Process	GO:0009749	response to glucose
Biological Process	GO:0009725	response to hormone
Biological Process	GO:0042542	response to hydrogen peroxide
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0035902	response to immobilization stress
Biological Process	GO:0002931	response to ischemia
Biological Process	GO:0010226	response to lithium ion
Biological Process	GO:0009612	response to mechanical stimulus
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0007172	signal complex assembly
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0002040	sprouting angiogenesis
Biological Process	GO:0043149	stress fiber assembly
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway
Molecular Function	GO:0043423	3-phosphoinositide-dependent protein kinase binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004972	NMDA glutamate receptor activity
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity
Molecular Function	GO:0043621	protein self-association
Molecular Function	GO:0004713	protein tyrosine kinase activity
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse
Cellular Component	GO:0097440	apical dendrite
Cellular Component	GO:0044297	cell body
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0099092	postsynaptic density, intracellular component
Cellular Component	GO:0098793	presynapse

InterPro / Pfam

InterPro	InterPro name
IPR000299	FERM domain
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR005189	Focal adhesion kinase, targeting (FAT) domain
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR011993	PH-like domain superfamily
IPR014352	FERM/acyl-CoA-binding protein superfamily
IPR017441	Protein kinase, ATP binding site
IPR019748	FERM central domain
IPR019749	Band 4.1 domain
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR029071	Ubiquitin-like domain superfamily
IPR035963	FERM superfamily, second domain
IPR036137	Focal adhesion kinase, targeting (FAT) domain superfamily
IPR041390	Focal adhesion kinase, N-terminal
IPR041784	FAK1/PYK2, FERM domain C-lobe

Pfam	Pfam name
PF00373	FERM central domain
PF03623	Focal adhesion targeting region
PF07714	Protein tyrosine and serine/threonine kinase
PF18038	FERM N-terminal domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-391160	Signal regulatory protein family interactions	Leaf	R-HSA-1500931	Cell-Cell communication
R-HSA-4420097	VEGFA-VEGFR2 Pathway	Internal node	R-HSA-162582	Signal Transduction
R-HSA-9013420	RHOU GTPase cycle	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9020558	Interleukin-2 signaling	Leaf	R-HSA-168256	Immune System

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Medium	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Low	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	Medium	Approved
cerebellum	Purkinje cells	Medium	Approved
cerebellum	cells in molecular layer	Low	Approved
cerebral cortex	neuronal cells	Medium	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	squamous epithelial cells	Low	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	Medium	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	glandular cells	Low	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Low	Approved
fallopian tube	ciliated cells (cell body)	High	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Low	Approved
hippocampus	neuronal cells	Medium	Approved
kidney	cells in tubules	Low	Approved
lung	macrophages	Low	Approved
lymph node	germinal center cells	Medium	Approved
lymph node	non-germinal center cells	Low	Approved
nasopharynx	basal cells	High	Approved
nasopharynx	ciliated cells (cell body)	High	Approved
nasopharynx	ciliated cells (ciliary rootlets)	Medium	Approved
pancreas	pancreatic endocrine cells	Low	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	trophoblastic cells	Medium	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Low	Approved
skin 1	keratinocytes	Low	Approved
skin 1	melanocytes	Medium	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	Low	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Medium	Approved
testis	cells in seminiferous ducts	Medium	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Medium	Approved
tonsil	squamous epithelial cells	Low	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	Medium	Approved

Location	ECO term	Pubmed
Cell junction, focal adhesion
Cell membrane
Cell projection, lamellipodium
Cytoplasm
Cytoplasm, cell cortex
Cytoplasm, perinuclear region
Nucleus

Summary of Q14289

Gene: PTK2B, FAK2, PYK2, RAFTK
Protein: Protein-tyrosine kinase 2-beta

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q14289

Gene: PTK2B, FAK2, PYK2, RAFTK Protein: Protein-tyrosine kinase 2-beta

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: PTK2B, FAK2, PYK2, RAFTK
Protein: Protein-tyrosine kinase 2-beta