MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2MH3		NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1
7C4O		Solution structure of the Orange domain from human protein HES1

GO term

GO ontology	GO term	GO description
Biological Process	GO:0030509	BMP signaling pathway
Biological Process	GO:0021870	Cajal-Retzius cell differentiation
Biological Process	GO:0007219	Notch signaling pathway
Biological Process	GO:0072050	S-shaped body morphogenesis
Biological Process	GO:0042098	T cell proliferation
Biological Process	GO:0021984	adenohypophysis development
Biological Process	GO:0035881	amacrine cell differentiation
Biological Process	GO:0009952	anterior/posterior pattern specification
Biological Process	GO:0048844	artery morphogenesis
Biological Process	GO:0035910	ascending aorta morphogenesis
Biological Process	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0001709	cell fate determination
Biological Process	GO:0048469	cell maturation
Biological Process	GO:0016477	cell migration
Biological Process	GO:0048667	cell morphogenesis involved in neuron differentiation
Biological Process	GO:0071398	cellular response to fatty acid
Biological Process	GO:0071347	cellular response to interleukin-1
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0090102	cochlea development
Biological Process	GO:0072049	comma-shaped body morphogenesis
Biological Process	GO:0061009	common bile duct development
Biological Process	GO:0003143	embryonic heart tube morphogenesis
Biological Process	GO:0090162	establishment of epithelial cell polarity
Biological Process	GO:0021861	forebrain radial glial cell differentiation
Biological Process	GO:0072012	glomerulus vasculature development
Biological Process	GO:0021575	hindbrain morphogenesis
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization
Biological Process	GO:0060716	labyrinthine layer blood vessel development
Biological Process	GO:0046331	lateral inhibition
Biological Process	GO:0001889	liver development
Biological Process	GO:0030324	lung development
Biological Process	GO:0072282	metanephric nephron tubule morphogenesis
Biological Process	GO:0030901	midbrain development
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:1902870	negative regulation of amacrine cell differentiation
Biological Process	GO:0090281	negative regulation of calcium ion import
Biological Process	GO:1905934	negative regulation of cell fate determination
Biological Process	GO:2000978	negative regulation of forebrain neuron differentiation
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:0060253	negative regulation of glial cell proliferation
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation
Biological Process	GO:0045665	negative regulation of neuron differentiation
Biological Process	GO:0010977	negative regulation of neuron projection development
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation
Biological Process	GO:2000227	negative regulation of pancreatic A cell differentiation
Biological Process	GO:2000974	negative regulation of pro-B cell differentiation
Biological Process	GO:2000737	negative regulation of stem cell differentiation
Biological Process	GO:0061106	negative regulation of stomach neuroendocrine cell differentiation
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0097150	neuronal stem cell population maintenance
Biological Process	GO:0021557	oculomotor nerve development
Biological Process	GO:0003151	outflow tract morphogenesis
Biological Process	GO:0003310	pancreatic A cell differentiation
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis
Biological Process	GO:0030513	positive regulation of BMP signaling pathway
Biological Process	GO:0043388	positive regulation of DNA binding
Biological Process	GO:0045747	positive regulation of Notch signaling pathway
Biological Process	GO:0042102	positive regulation of T cell proliferation
Biological Process	GO:0048711	positive regulation of astrocyte differentiation
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0045977	positive regulation of mitotic cell cycle, embryonic
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
Biological Process	GO:0065003	protein-containing complex assembly
Biological Process	GO:0050678	regulation of epithelial cell proliferation
Biological Process	GO:0045598	regulation of fat cell differentiation
Biological Process	GO:0050767	regulation of neurogenesis
Biological Process	GO:0043254	regulation of protein-containing complex assembly
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT
Biological Process	GO:0003266	regulation of secondary heart field cardioblast proliferation
Biological Process	GO:0060164	regulation of timing of neuron differentiation
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0072141	renal interstitial fibroblast development
Biological Process	GO:0043279	response to alkaloid
Biological Process	GO:0014070	response to organic cyclic compound
Biological Process	GO:0097066	response to thyroid hormone
Biological Process	GO:0007224	smoothened signaling pathway
Biological Process	GO:0035019	somatic stem cell population maintenance
Biological Process	GO:0061102	stomach neuroendocrine cell differentiation
Biological Process	GO:0021537	telencephalon development
Biological Process	GO:0048538	thymus development
Biological Process	GO:0021558	trochlear nerve development
Biological Process	GO:0060675	ureteric bud morphogenesis
Biological Process	GO:0097084	vascular associated smooth muscle cell development
Biological Process	GO:0003281	ventricular septum development
Biological Process	GO:0060412	ventricular septum morphogenesis
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function	GO:0070888	E-box binding
Molecular Function	GO:0043398	HLH domain binding
Molecular Function	GO:0008432	JUN kinase binding
Molecular Function	GO:0071820	N-box binding
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0051087	protein-folding chaperone binding
Molecular Function	GO:0043565	sequence-specific DNA binding
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding
Molecular Function	GO:0001222	transcription corepressor binding
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex

InterPro	InterPro name
IPR003650	Orange domain
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR036638	Helix-loop-helix DNA-binding domain superfamily

Pfam	Pfam name
PF00010	Helix-loop-helix DNA-binding domain
PF07527	Hairy Orange

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8941856	RUNX3 regulates NOTCH signaling	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction

Summary of Q14469

Gene: HES1, BHLHB39, HL, HRY
Protein: Transcription factor HES-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q14469

Gene: HES1, BHLHB39, HL, HRY Protein: Transcription factor HES-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: HES1, BHLHB39, HL, HRY
Protein: Transcription factor HES-1