MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.10.2	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases; non-specific protein-tyrosine kinase
2.7.11.1	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; non-specific serine/threonine protein kinase

Structure

PDB	Resolution (Å)	PDB name
4BKY	1.83	Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with pyrrolopyrazole inhibitor
4BKZ	2.2	Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with a benzodipyrazole inhibitor
4BL1	2.6	Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with AMP-PNP
4D2P	2.55	Structure of MELK in complex with inhibitors
4D2T	2.7	Structure of MELK in complex with inhibitors
4D2V	2.45	Structure of MELK in complex with inhibitors
4D2W	1.92	Structure of MELK in complex with inhibitors
4IXP	2.749	Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK)
4UMP	2.3	Structure of MELK in complex with inhibitors
4UMQ	2.6	Structure of MELK in complex with inhibitors
4UMR	3.0	Structure of MELK in complex with inhibitors
4UMT	1.98	Structure of MELK in complex with inhibitors
4UMU	2.02	Structure of MELK in complex with inhibitors
5IH8	1.85	MELK in complex with NVS-MELK1
5IH9	1.79	MELK in complex with NVS-MELK8A
5IHA	1.96	MELK in complex with NVS-MELK8F
5IHC	2.14	MELK in complex with NVS-MELK12B
5K00	1.77	MELK in complex with NVS-MELK5
5M5A	1.9	Crystal structure of MELK in complex with an inhibitor
5MAF	2.8	Crystal structure of MELK in complex with an inhibitor
5MAG	2.35	Crystal structure of MELK in complex with an inhibitor
5MAH	2.0	Crystal structure of MELK in complex with an inhibitor
5MAI	2.15	Crystal structure of MELK in complex with an inhibitor
5TVT	2.28	Structure of Maternal Embryonic Leucine Zipper Kinase
5TWL	2.42	Structure of Maternal Embryonic Leucine Zipper Kinase
5TWU	2.603	Structure of Maternal Embryonic Leucine Zipper Kinase
5TWY	2.91	Structure of Maternal Embryonic Leucine Zipper Kinase
5TWZ	2.631	Structure of Maternal Embryonic Leucine Zipper Kinase
5TX3	2.9	Structure of Maternal Embryonic Leucine Zipper Kinase
6GVX	2.24	Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C)
6VXR	2.1	Structure of Maternal embryonic leucine zipper kinase bound to LDSM276

GO term

GO ontology	GO term	GO description
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0008283	cell population proliferation
Biological Process	GO:0030097	hemopoiesis
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
Biological Process	GO:0061351	neural precursor cell proliferation
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0046777	protein autophosphorylation
Biological Process	GO:0006468	protein phosphorylation
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0008289	lipid binding
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane

InterPro	InterPro name
IPR000719	Protein kinase domain
IPR001772	Kinase associated domain 1 (KA1)
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site
IPR028375	KA1 domain/Ssp2, C-terminal
IPR034673	Maternal embryonic leucine zipper kinase, catalytic domain

Pfam	Pfam name
PF00069	Protein kinase domain
PF02149	Kinase associated domain 1

Location	ECO term	Pubmed
Cell membrane	ECO:0000269	PubMed:16159311
Cell membrane	ECO:0000269	PubMed:21145462

Summary of Q14680

Gene: MELK, KIAA0175
Protein: Maternal embryonic leucine zipper kinase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q14680

Gene: MELK, KIAA0175 Protein: Maternal embryonic leucine zipper kinase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: MELK, KIAA0175
Protein: Maternal embryonic leucine zipper kinase