Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.3.2.27
Transferases;
Acyltransferases;
Aminoacyltransferases;
RING-type E3 ubiquitin transferase
3.6.4.-
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement;
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0000209 | protein polyubiquitination |
| Biological Process | GO:0016567 | protein ubiquitination |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0140658 | ATP-dependent chromatin remodeler activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0004386 | helicase activity |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| InterPro
|
InterPro name |
|---|---|
| IPR000330 | SNF2, N-terminal |
| IPR001650 | Helicase, C-terminal |
| IPR001841 | Zinc finger, RING-type |
| IPR001965 | Zinc finger, PHD-type |
| IPR005818 | Linker histone H1/H5, domain H15 |
| IPR011011 | Zinc finger, FYVE/PHD-type |
| IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| IPR017907 | Zinc finger, RING-type, conserved site |
| IPR019786 | Zinc finger, PHD-type, conserved site |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| IPR036388 | Winged helix-like DNA-binding domain superfamily |
| IPR036390 | Winged helix DNA-binding domain superfamily |
| IPR038718 | SNF2-like, N-terminal domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00176 | SNF2-related domain |
| PF00271 | Helicase conserved C-terminal domain |
| PF00538 | linker histone H1 and H5 family |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| Location
|
ECO term
|
Pubmed |
|---|
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | High | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | High | Approved |
| breast | adipocytes | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | High | Approved |
| bronchus | basal cells | Low | Approved |
| bronchus | ciliated cells (cell body) | High | Approved |
| bronchus | ciliated cells (cilia axoneme) | High | Approved |
| bronchus | ciliated cells (tip of cilia) | High | Approved |
| bronchus | goblet cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | High | Approved |
| cerebellum | cells in molecular layer | Low | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | High | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | High | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | Medium | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | ciliated cells (cell body) | Low | Approved |
| fallopian tube | ciliated cells (cilia axoneme) | High | Approved |
| fallopian tube | ciliated cells (tip of cilia) | High | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | High | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in glomeruli | Medium | Approved |
| kidney | cells in tubules | High | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | High | Approved |
| lung | alveolar cells | Medium | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | High | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | High | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | High | Approved |
| skin 2 | epidermal cells | High | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | High | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | High | Approved |
| soft tissue 2 | fibroblasts | High | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | Medium | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | High | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | High | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|