Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.7.-
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases;
6.1.1.6
Ligases;
Forming carbon-oxygen bonds;
Ligases forming aminoacyl-tRNA and related compounds;
lysine—tRNA ligase
PDB | Resolution (Å) | PDB name |
---|---|---|
3BJU | 2.31 | Crystal Structure of tetrameric form of human lysyl-tRNA synthetase |
4DPG | 2.844 | Crystal Structure of Human LysRS: P38/AIMP2 Complex I |
4YCU | 2.1 | Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase |
4YCW | 2.9 | Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant |
6CHD | 2.5 | Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine |
6ILD | 1.882 | Crystal Structure of Human LysRS: P38/AIMP2 Complex II |
6ILH | 2.501 | Crystal Structure of human lysyl-tRNA synthetase L350H mutant |
7EA9 | 2.5 | Crystal Structure of human lysyl-tRNA synthetase Y145H mutant |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0070371 | ERK1 and ERK2 cascade |
Biological Process | GO:0002276 | basophil activation involved in immune response |
Biological Process | GO:0015966 | diadenosine tetraphosphate biosynthetic process |
Biological Process | GO:0006430 | lysyl-tRNA aminoacylation |
Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
Biological Process | GO:0002863 | positive regulation of inflammatory response to antigenic stimulus |
Biological Process | GO:0043032 | positive regulation of macrophage activation |
Biological Process | GO:0010165 | response to X-ray |
Biological Process | GO:0008033 | tRNA processing |
Molecular Function | GO:0003877 | ATP adenylyltransferase activity |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0016597 | amino acid binding |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0004824 | lysine-tRNA ligase activity |
Molecular Function | GO:0042803 | protein homodimerization activity |
Molecular Function | GO:0000049 | tRNA binding |
Cellular Component | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005615 | extracellular space |
Cellular Component | GO:0005759 | mitochondrial matrix |
Cellular Component | GO:0005739 | mitochondrion |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0005886 | plasma membrane |
InterPro | InterPro name |
---|---|
IPR002313 | Lysine-tRNA ligase, class II |
IPR004364 | Aminoacyl-tRNA synthetase, class II (D/K/N) |
IPR004365 | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
IPR006195 | Aminoacyl-tRNA synthetase, class II |
IPR012340 | Nucleic acid-binding, OB-fold |
IPR018149 | Lysyl-tRNA synthetase, class II, C-terminal |
IPR034762 | Bacterial/eukaryotic lysine-tRNA ligase, class II |
IPR044136 | Lysine-tRNA ligase, class II, N-terminal |
IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Pfam | Pfam name |
---|---|
PF00152 | tRNA synthetases class II (D, K and N) |
PF01336 | OB-fold nucleic acid binding domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-2408522 | Selenoamino acid metabolism | Internal node | R-HSA-1430728 | Metabolism |
R-HSA-379716 | Cytosolic tRNA aminoacylation | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-379726 | Mitochondrial tRNA aminoacylation | Leaf | R-HSA-392499 | Metabolism of proteins |
Location | ECO term | Pubmed |
---|---|---|
Cell membrane | ECO:0000269 | PubMed:15220430 |
Cytoplasm | ECO:0000269 | PubMed:15220430 |
Cytoplasm, cytosol | ECO:0000269 | PubMed:10952987 |
Cytoplasm, cytosol | ECO:0000269 | PubMed:19289464 |
Cytoplasm, cytosol | ECO:0000269 | PubMed:23159739 |
Cytoplasm, cytosol | ECO:0000269 | PubMed:28887846 |
Mitochondrion | ECO:0000269 | PubMed:10952987 |
Nucleus | ECO:0000269 | PubMed:15220430 |
Nucleus | ECO:0000269 | PubMed:23159739 |
Secreted | ECO:0000269 | PubMed:15851690 |
HPO ID | HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0000047 | Hypospadias |
HP:0000083 | Renal insufficiency |
HP:0000160 | Narrow mouth |
HP:0000252 | Microcephaly |
HP:0000343 | Long philtrum |
HP:0000365 | Hearing impairment |
HP:0000407 | Sensorineural hearing impairment |
HP:0000529 | Progressive visual loss |
HP:0000639 | Nystagmus |
HP:0000821 | Hypothyroidism |
HP:0001250 | Seizure |
HP:0001251 | Ataxia |
HP:0001252 | Hypotonia |
HP:0001263 | Global developmental delay |
HP:0001265 | Hyporeflexia |
HP:0001268 | Mental deterioration |
HP:0001270 | Motor delay |
HP:0001276 | Hypertonia |
HP:0001284 | Areflexia |
HP:0001332 | Dystonia |
HP:0001344 | Absent speech |
HP:0001508 | Failure to thrive |
HP:0001510 | Growth delay |
HP:0001518 | Small for gestational age |
HP:0001756 | Vestibular hypofunction |
HP:0001761 | Pes cavus |
HP:0001903 | Anemia |
HP:0001946 | Ketosis |
HP:0002013 | Vomiting |
HP:0002151 | Increased serum lactate |
HP:0002304 | Akinesia |
HP:0002344 | Progressive neurologic deterioration |
HP:0002352 | Leukoencephalopathy |
HP:0002376 | Developmental regression |
HP:0002415 | Leukodystrophy |
HP:0002510 | Spastic tetraplegia |
HP:0002514 | Cerebral calcification |
HP:0002750 | Delayed skeletal maturation |
HP:0002936 | Distal sensory impairment |
HP:0003348 | Hyperalaninemia |
HP:0003376 | Steppage gait |
HP:0003477 | Peripheral axonal neuropathy |
HP:0003542 | Increased serum pyruvate |
HP:0003577 | Congenital onset |
HP:0003593 | Infantile onset |
HP:0003819 | Death in childhood |
HP:0004840 | Hypochromic microcytic anemia |
HP:0007103 | Hypointensity of cerebral white matter on MRI |
HP:0007256 | Abnormal pyramidal sign |
HP:0008527 | Congenital sensorineural hearing impairment |
HP:0008972 | Decreased activity of mitochondrial respiratory chain |
HP:0009027 | Foot dorsiflexor weakness |
HP:0009588 | Vestibular schwannoma |
HP:0010818 | Generalized tonic seizure |
HP:0011344 | Severe global developmental delay |
HP:0011476 | Profound sensorineural hearing impairment |
HP:0012595 | Mild proteinuria |
HP:0012707 | Elevated brain lactate level by MRS |
HP:0031936 | Delayed ability to walk |
HP:0033383 | Decreased compound muscle action potential amplitude |
HP:0040209 | Decreased CSF biopterin level |
HP:0100543 | Cognitive impairment |
HP:0100716 | Self-injurious behavior |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
optic nerve disorder | MONDO:0002135 | H47 | chapter7, Diseases of the eye and adnexa | Orphanet:519351 | |
charcot-marie-tooth disease recessive intermediate b | MONDO:0013338 | G60 | chapter6, Diseases of the nervous system | OMIM:613641 | Orphanet:254334 |
autosomal recessive nonsyndromic hearing loss 89 | MONDO:0013489 | H90 | chapter8, Diseases of the ear and mastoid process | OMIM:613916 | |
leukoencephalopathy- progressive- infantile-onset- with or without deafness | MONDO:0030893 | G93 | chapter6, Diseases of the nervous system | OMIM:619147 | |
deafness- congenital- and adult-onset progressive leukoencephalopathy | MONDO:0030967 | - | - | OMIM:619196 |