Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.1.2
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
arylesterase
3.1.1.81
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
quorum-quenching N-acyl-homoserine lactonase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0019439 | aromatic compound catabolic process |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0009636 | response to toxic substance |
| Molecular Function | GO:0102007 | acyl-L-homoserine-lactone lactonohydrolase activity |
| Molecular Function | GO:0004064 | arylesterase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Membrane | ECO:0000269 | PubMed:11579088 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000217 | Xerostomia |
| HP:0000712 | Emotional lability |
| HP:0000713 | Agitation |
| HP:0000716 | Depression |
| HP:0000739 | Anxiety |
| HP:0001257 | Spasticity |
| HP:0002017 | Nausea and vomiting |
| HP:0002094 | Dyspnea |
| HP:0002180 | Neurodegeneration |
| HP:0002795 | Abnormal respiratory system physiology |
| HP:0002878 | Respiratory failure |
| HP:0003202 | Skeletal muscle atrophy |
| HP:0003324 | Generalized muscle weakness |
| HP:0003394 | Muscle spasm |
| HP:0003470 | Paralysis |
| HP:0007354 | Amyotrophic lateral sclerosis |
| HP:0007373 | Motor neuron atrophy |
| HP:0012378 | Fatigue |
| HP:0012531 | Pain |
| HP:0025425 | Laryngospasm |
| HP:0030192 | Fatigable weakness of bulbar muscles |
| HP:0030195 | Fatigable weakness of swallowing muscles |
| HP:0030196 | Fatigable weakness of respiratory muscles |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Enhanced |
| adrenal gland | glandular cells | High | Enhanced |
| appendix | glandular cells | High | Enhanced |
| appendix | lymphoid tissue | Medium | Enhanced |
| bone marrow | hematopoietic cells | Medium | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| breast | myoepithelial cells | Low | Enhanced |
| bronchus | respiratory epithelial cells | Medium | Enhanced |
| caudate | glial cells | High | Enhanced |
| caudate | neuronal cells | Medium | Enhanced |
| cerebellum | Bergmann glia - cytoplasm/membrane | High | Enhanced |
| cerebellum | granular cells - cytoplasm/membrane | High | Enhanced |
| cerebellum | molecular layer cells - cytoplasm/membrane | High | Enhanced |
| cerebellum | processes in granular layer | Low | Enhanced |
| cerebellum | processes in molecular layer | High | Enhanced |
| cerebellum | white matter cells - cytoplasm/membrane | High | Enhanced |
| cerebral cortex | endothelial cells | Medium | Enhanced |
| cerebral cortex | glial cells | High | Enhanced |
| cerebral cortex | neuronal cells | Low | Enhanced |
| cerebral cortex | neuropil | Low | Enhanced |
| cervix | glandular cells | Low | Enhanced |
| cervix | squamous epithelial cells | Low | Enhanced |
| colon | endothelial cells | Low | Enhanced |
| colon | glandular cells | Medium | Enhanced |
| colon | peripheral nerve/ganglion | Low | Enhanced |
| duodenum | glandular cells | High | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | glandular cells | Medium | Enhanced |
| epididymis | glandular cells | High | Enhanced |
| fallopian tube | glandular cells | Medium | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| heart muscle | cardiomyocytes | Medium | Enhanced |
| hippocampus | glial cells | High | Enhanced |
| hippocampus | neuronal cells | Medium | Enhanced |
| kidney | cells in glomeruli | Low | Enhanced |
| kidney | cells in tubules | High | Enhanced |
| liver | cholangiocytes | Medium | Enhanced |
| liver | hepatocytes | Medium | Enhanced |
| lung | alveolar cells type II | High | Enhanced |
| lung | endothelial cells | Medium | Enhanced |
| lung | macrophages | Medium | Enhanced |
| lymph node | germinal center cells | Low | Enhanced |
| lymph node | non-germinal center cells | Low | Enhanced |
| nasopharynx | respiratory epithelial cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Low | Enhanced |
| ovary | follicle cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | Medium | Enhanced |
| pancreas | pancreatic endocrine cells | Medium | Enhanced |
| parathyroid gland | glandular cells | Medium | Enhanced |
| placenta | cytotrophoblasts | Medium | Enhanced |
| placenta | endothelial cells | High | Enhanced |
| placenta | hofbauer cells | High | Enhanced |
| placenta | syncytiotrophoblasts - cell body | High | Enhanced |
| placenta | syncytiotrophoblasts - microvilli | High | Enhanced |
| prostate | glandular cells | Medium | Enhanced |
| rectum | glandular cells | High | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Low | Enhanced |
| skin 1 | cells in basal layer | Low | Enhanced |
| skin 1 | cells in spinous layer | Low | Enhanced |
| skin 1 | eccrine glands | Low | Enhanced |
| skin 1 | endothelial cells | Medium | Enhanced |
| skin 1 | fibrohistiocytic cells | High | Enhanced |
| skin 1 | langerhans cells | Low | Enhanced |
| skin 1 | melanocytes | High | Enhanced |
| skin 2 | cells in basal layer | Medium | Enhanced |
| skin 2 | cells in granular layer | Low | Enhanced |
| skin 2 | cells in spinous layer | Low | Enhanced |
| skin 2 | endothelial cells | Medium | Enhanced |
| skin 2 | fibrohistiocytic cells | High | Enhanced |
| skin 2 | langerhans cells | Low | Enhanced |
| skin 2 | lymphocytes | Low | Enhanced |
| skin 2 | melanocytes | High | Enhanced |
| small intestine | glandular cells | High | Enhanced |
| smooth muscle | smooth muscle cells | Low | Enhanced |
| soft tissue 1 | chondrocytes | Medium | Enhanced |
| soft tissue 1 | fibroblasts | Medium | Enhanced |
| soft tissue 2 | fibroblasts | Medium | Enhanced |
| soft tissue 2 | peripheral nerve | Low | Enhanced |
| spleen | cells in red pulp | Medium | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | Leydig cells | Medium | Enhanced |
| testis | sertoli cells | High | Enhanced |
| thyroid gland | glandular cells | High | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | High | Enhanced |
| urinary bladder | urothelial cells | High | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| amyotrophic lateral sclerosis | MONDO:0004976 | G12 | chapter6, Diseases of the nervous system | Orphanet:803 |