MultifacetedProtDB - Bologna Biocomputing Group

Catalytic activity

EC number	EC number description
3.1.1.2	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; arylesterase
3.1.1.81	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; quorum-quenching N-acyl-homoserine lactonase
3.1.8.1	Hydrolases; Acting on ester bonds; Phosphoric-triester hydrolases; aryldialkylphosphatase

Publications

GO ontology	GO term	GO description
Biological Process	GO:0019439	aromatic compound catabolic process
Biological Process	GO:0046395	carboxylic acid catabolic process
Biological Process	GO:0046226	coumarin catabolic process
Biological Process	GO:0051649	establishment of localization in cell
Biological Process	GO:0032929	negative regulation of superoxide anion generation
Biological Process	GO:0010124	phenylacetate catabolic process
Biological Process	GO:0003096	renal sodium ion transport
Biological Process	GO:0009636	response to toxic substance
Molecular Function	GO:0018733	3,4-dihydrocoumarin hydrolase activity
Molecular Function	GO:0102007	acyl-L-homoserine-lactone lactonohydrolase activity
Molecular Function	GO:0004063	aryldialkylphosphatase activity
Molecular Function	GO:0004064	arylesterase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0042803	protein homodimerization activity
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space

InterPro	InterPro name
IPR002640	Arylesterase
IPR008364	Paraoxonase2
IPR011042	Six-bladed beta-propeller, TolB-like

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	Leaf	R-HSA-1430728	Metabolism
R-HSA-9754706	Atorvastatin ADME	Leaf	R-HSA-9748784	Drug ADME

HPO ID	HPO name
HP:0000217	Xerostomia
HP:0000712	Emotional lability
HP:0000713	Agitation
HP:0000716	Depression
HP:0000739	Anxiety
HP:0001257	Spasticity
HP:0002017	Nausea and vomiting
HP:0002094	Dyspnea
HP:0002180	Neurodegeneration
HP:0002795	Abnormal respiratory system physiology
HP:0002878	Respiratory failure
HP:0003202	Skeletal muscle atrophy
HP:0003324	Generalized muscle weakness
HP:0003394	Muscle spasm
HP:0003470	Paralysis
HP:0007354	Amyotrophic lateral sclerosis
HP:0007373	Motor neuron atrophy
HP:0012378	Fatigue
HP:0012531	Pain
HP:0025425	Laryngospasm
HP:0030192	Fatigable weakness of bulbar muscles
HP:0030195	Fatigable weakness of swallowing muscles
HP:0030196	Fatigable weakness of respiratory muscles

Tissue	Cell type	Expression level	Reliability
breast	glandular cells	Low	Enhanced
gallbladder	glandular cells	Low	Enhanced
liver	hepatocytes	High	Enhanced
lung	alveolar cells type II	Medium	Enhanced
lung	macrophages	Low	Enhanced