Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
7.6.2.2
Translocases;
Catalysing the translocation of other compounds;
Linked to the hydrolysis of a nucleoside triphosphate;
ABC-type xenobiotic transporter
7.6.2.3
Translocases;
Catalysing the translocation of other compounds;
Linked to the hydrolysis of a nucleoside triphosphate;
ABC-type glutathione-S-conjugate transporter
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2KWH | Ral binding domain of RLIP76 (RalBP1) | |
| 2KWI | RalB-RLIP76 (RalBP1) complex | |
| 2MBG | Rlip76 (gap-gbd) | |
| 6ZQT | 1.51 | Crystal structure of the RLIP76 Ral binding domain mutant (E427H/Q433L/K440R) in complex with RalB-GMPPNP |
| 6ZRN | 1.482 | Crystal structure of the RLIP76 Ral binding domain mutant (E427S/L429M/Q433L/K440R) in complex with RalB-GMPPNP |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006935 | chemotaxis |
| Biological Process | GO:1900753 | doxorubicin transport |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:0090141 | positive regulation of mitochondrial fission |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0032489 | regulation of Cdc42 protein signal transduction |
| Biological Process | GO:0043087 | regulation of GTPase activity |
| Biological Process | GO:0051056 | regulation of small GTPase mediated signal transduction |
| Biological Process | GO:0007264 | small GTPase mediated signal transduction |
| Biological Process | GO:0055085 | transmembrane transport |
| Biological Process | GO:1990961 | xenobiotic detoxification by transmembrane export across the plasma membrane |
| Molecular Function | GO:0015431 | ABC-type glutathione S-conjugate transporter activity |
| Molecular Function | GO:0008559 | ABC-type xenobiotic transporter activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042626 | ATPase-coupled transmembrane transporter activity |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0022857 | transmembrane transporter activity |
| Molecular Function | GO:0042910 | xenobiotic transmembrane transporter activity |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0000922 | spindle pole |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-9013148 | CDC42 GTPase cycle | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-9013149 | RAC1 GTPase cycle | Leaf | R-HSA-162582 | Signal Transduction |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ECO:0000269 | PubMed:10924126 |
| Cell membrane | ECO:0000269 | PubMed:11437348 |
| Cell membrane | ECO:0000269 | PubMed:15610018 |
| Cytoplasm, cytoskeleton, spindle pole | ECO:0000250 | |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:15610018 |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:22319010 |
| Mitochondrion | ECO:0000269 | PubMed:21822277 |
| Nucleus | ECO:0000269 | PubMed:22319010 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | ciliated cells (ciliary rootlets) | High | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | ciliated cells (cell body) | Low | Approved |
| fallopian tube | ciliated cells (ciliary rootlets) | Medium | Approved |
| fallopian tube | non-ciliated cells | Low | Approved |
| gallbladder | glandular cells | Medium | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Low | Approved |
| lung | alveolar cells | Medium | Approved |
| lung | macrophages | Low | Approved |
| lymph node | germinal center cells | Low | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | ciliated cells (cell body) | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Medium | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | decidual cells | Medium | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | Medium | Approved |
| spleen | cells in red pulp | Low | Approved |
| spleen | cells in white pulp | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Low | Approved |
| tonsil | non-germinal center cells | Low | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|