MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1KHU	2.5	Smad1 crystal structure reveals the details of BMP signaling pathway
2LAW		Structure of the second WW domain from human YAP in complex with a human Smad1 derived peptide
2LAX		Structure of first WW domain of human YAP in complex with a human Smad1 doubly-phosphorilated derived peptide.
2LAY		Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived peptide
2LAZ		Structure of the first WW domain of human Smurf1 in complex with a mono-phosphorylated human Smad1 derived peptide
2LB0		Structure of the first WW domain of human Smurf1 in complex with a di-phosphorylated human Smad1 derived peptide
2LB1		Structure of the second domain of human Smurf1 in complex with a human Smad1 derived peptide
3Q47	1.705	Crystal structure of TPR domain of CHIP complexed with pseudophosphorylated Smad1 peptide
3Q4A	1.542	Crystal structure of the TPR domain of CHIP complexed with phosphorylated Smad1 peptide
5ZOK	2.85	Crystal structure of human SMAD1-MAN1 complex.

GO term

GO ontology	GO term	GO description
Biological Process	GO:0030509	BMP signaling pathway
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0000165	MAPK cascade
Biological Process	GO:0007183	SMAD protein complex assembly
Biological Process	GO:0060395	SMAD protein signal transduction
Biological Process	GO:0009653	anatomical structure morphogenesis
Biological Process	GO:0060348	bone development
Biological Process	GO:0003161	cardiac conduction system development
Biological Process	GO:0060038	cardiac muscle cell proliferation
Biological Process	GO:0051216	cartilage development
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0071407	cellular response to organic cyclic compound
Biological Process	GO:0009880	embryonic pattern specification
Biological Process	GO:0007276	gamete generation
Biological Process	GO:0030902	hindbrain development
Biological Process	GO:0042592	homeostatic process
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0001710	mesodermal cell fate commitment
Biological Process	GO:0030901	midbrain development
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0051148	negative regulation of muscle cell differentiation
Biological Process	GO:0001649	osteoblast differentiation
Biological Process	GO:0002051	osteoblast fate commitment
Biological Process	GO:0061036	positive regulation of cartilage development
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:1902895	positive regulation of miRNA transcription
Biological Process	GO:0045669	positive regulation of osteoblast differentiation
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
Biological Process	GO:0031053	primary miRNA processing
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0006366	transcription by RNA polymerase II
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway
Biological Process	GO:0001657	ureteric bud development
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function	GO:0003700	DNA-binding transcription factor activity
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0070411	I-SMAD binding
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0070410	co-SMAD binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0070878	primary miRNA binding
Molecular Function	GO:0019901	protein kinase binding
Cellular Component	GO:0071141	SMAD protein complex
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0071144	heteromeric SMAD protein complex
Cellular Component	GO:0071142	homomeric SMAD protein complex
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005637	nuclear inner membrane
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex

InterPro / Pfam

InterPro	InterPro name
IPR001132	SMAD domain, Dwarfin-type
IPR003619	MAD homology 1, Dwarfin-type
IPR008984	SMAD/FHA domain superfamily
IPR013019	MAD homology, MH1
IPR013790	Dwarfin
IPR017855	SMAD-like domain superfamily
IPR036578	SMAD MH1 domain superfamily

Pfam	Pfam name
PF03165	MH1 domain
PF03166	MH2 domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-201451	Signaling by BMP	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5689880	Ub-specific processing proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-8941326	RUNX2 regulates bone development	Internal node	R-HSA-74160	Gene expression (Transcription)

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:15647271
Nucleus	ECO:0000269	PubMed:15647271
Nucleus	ECO:0000269	PubMed:22781750

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Approved
appendix	glandular cells	Medium	Approved
bone marrow	hematopoietic cells	Low	Approved
breast	adipocytes	Low	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Medium	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	glial cells	Medium	Approved
caudate	neuronal cells	Low	Approved
cerebellum	cells in molecular layer	Medium	Approved
cerebral cortex	endothelial cells	Low	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Low	Approved
cervix	squamous epithelial cells	Low	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	Low	Approved
colon	peripheral nerve/ganglion	Low	Approved
duodenum	glandular cells	Low	Approved
endometrium 1	glandular cells	Low	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	High	Approved
fallopian tube	glandular cells	Low	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Medium	Approved
hippocampus	glial cells	Medium	Approved
kidney	cells in tubules	Medium	Approved
lung	macrophages	Medium	Approved
lymph node	germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
oral mucosa	squamous epithelial cells	Low	Approved
pancreas	exocrine glandular cells	Low	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
placenta	decidual cells	Low	Approved
placenta	trophoblastic cells	Medium	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Low	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	Low	Approved
skin 1	keratinocytes	Low	Approved
skin 1	melanocytes	Low	Approved
small intestine	glandular cells	Medium	Approved
soft tissue 1	fibroblasts	Low	Approved
soft tissue 1	peripheral nerve	Low	Approved
soft tissue 2	fibroblasts	Low	Approved
soft tissue 2	peripheral nerve	Low	Approved
stomach 1	glandular cells	High	Approved
stomach 2	glandular cells	Low	Approved
testis	Leydig cells	Low	Approved
testis	spermatogonia cells	Medium	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	Medium	Approved

Summary of Q15797

Gene: SMAD1, BSP1, MADH1, MADR1
Protein: Mothers against decapentaplegic homolog 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q15797

Gene: SMAD1, BSP1, MADH1, MADR1 Protein: Mothers against decapentaplegic homolog 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: SMAD1, BSP1, MADH1, MADR1
Protein: Mothers against decapentaplegic homolog 1