MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1US7	2.3	Complex of Hsp90 and P50
2K5B		Human CDC37-HSP90 docking model based on NMR
2N5X		C-terminal domain of Cdc37 cochaperone
2NCA		Structural Model for the N-terminal Domain of Human Cdc37
2W0G	1.88	HSP90 CO-CHAPERONE CDC37
5FWK	3.9	Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
5FWL	9.0	Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
5FWM	8.0	Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
5FWP	7.2	Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
5HPE	2.27	Phosphatase domain of PP5 bound to a phosphomimetic Cdc37 substrate peptide
7Z37	3.67	Structure of the RAF1-HSP90-CDC37 complex (RHC-II)
7Z38	3.16	Structure of the RAF1-HSP90-CDC37 complex (RHC-I)
7ZR0	3.4	CryoEM structure of HSP90-CDC37-BRAF(V600E) complex.
7ZR5	3.9	CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex
7ZR6	4.2	CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex

GO term

GO ontology	GO term	GO description
Biological Process	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization
Biological Process	GO:0010608	post-transcriptional regulation of gene expression
Biological Process	GO:0006457	protein folding
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0006605	protein targeting
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process	GO:0060338	regulation of type I interferon-mediated signaling pathway
Biological Process	GO:0060334	regulation of type II interferon-mediated signaling pathway
Molecular Function	GO:0051879	Hsp90 protein binding
Molecular Function	GO:0031072	heat shock protein binding
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0019887	protein kinase regulator activity
Molecular Function	GO:0051087	protein-folding chaperone binding
Molecular Function	GO:0097110	scaffold protein binding
Molecular Function	GO:0051082	unfolded protein binding
Cellular Component	GO:1990565	HSP90-CDC37 chaperone complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0101031	protein folding chaperone complex

InterPro / Pfam

InterPro	InterPro name
IPR004918	Cdc37
IPR013855	Cdc37, N-terminal domain
IPR013873	Cdc37, C-terminal
IPR013874	Cdc37, Hsp90 binding
IPR038189	Cdc37, Hsp90-binding domain superfamily

Pfam	Pfam name
PF03234	Cdc37 N terminal kinase binding
PF08564	Cdc37 C terminal domain
PF08565	Cdc37 Hsp90 binding domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1227986	Signaling by ERBB2	Internal node	R-HSA-162582	Signal Transduction
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	Leaf	R-HSA-1643685	Disease
R-HSA-5637810	Constitutive Signaling by EGFRvIII	Leaf	R-HSA-1643685	Disease
R-HSA-5675482	Regulation of necroptotic cell death	Internal node	R-HSA-5357801	Programmed Cell Death
R-HSA-8863795	Downregulation of ERBB2 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-9013418	RHOBTB2 GTPase cycle	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9634285	Constitutive Signaling by Overexpressed ERBB2	Leaf	R-HSA-1643685	Disease
R-HSA-9652282	Drug-mediated inhibition of ERBB2 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9664565	Signaling by ERBB2 KD Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-9665233	Resistance of ERBB2 KD mutants to trastuzumab	Leaf	R-HSA-1643685	Disease
R-HSA-9665244	Resistance of ERBB2 KD mutants to sapitinib	Leaf	R-HSA-1643685	Disease
R-HSA-9665245	Resistance of ERBB2 KD mutants to tesevatinib	Leaf	R-HSA-1643685	Disease
R-HSA-9665246	Resistance of ERBB2 KD mutants to neratinib	Leaf	R-HSA-1643685	Disease
R-HSA-9665247	Resistance of ERBB2 KD mutants to osimertinib	Leaf	R-HSA-1643685	Disease
R-HSA-9665249	Resistance of ERBB2 KD mutants to afatinib	Leaf	R-HSA-1643685	Disease
R-HSA-9665250	Resistance of ERBB2 KD mutants to AEE788	Leaf	R-HSA-1643685	Disease
R-HSA-9665251	Resistance of ERBB2 KD mutants to lapatinib	Leaf	R-HSA-1643685	Disease
R-HSA-9665348	Signaling by ERBB2 ECD mutants	Leaf	R-HSA-1643685	Disease
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	Leaf	R-HSA-1643685	Disease
R-HSA-9665737	Drug resistance in ERBB2 TMD/JMD mutants	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:9482106

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Supported
adrenal gland	glandular cells	Medium	Supported
appendix	glandular cells	Medium	Supported
appendix	lymphoid tissue	Low	Supported
bone marrow	hematopoietic cells	Medium	Supported
breast	glandular cells	Medium	Supported
breast	myoepithelial cells	Medium	Supported
bronchus	respiratory epithelial cells	Medium	Supported
caudate	glial cells	Low	Supported
caudate	neuronal cells	Medium	Supported
cerebellum	Purkinje cells	Medium	Supported
cerebellum	cells in molecular layer	Medium	Supported
cerebral cortex	glial cells	Medium	Supported
cerebral cortex	neuronal cells	Medium	Supported
cerebral cortex	neuropil	Medium	Supported
cervix	glandular cells	Medium	Supported
cervix	squamous epithelial cells	Low	Supported
colon	endothelial cells	Medium	Supported
colon	glandular cells	Medium	Supported
colon	peripheral nerve/ganglion	Medium	Supported
duodenum	glandular cells	Medium	Supported
endometrium 1	cells in endometrial stroma	Low	Supported
endometrium 1	glandular cells	Medium	Supported
endometrium 2	cells in endometrial stroma	Low	Supported
endometrium 2	glandular cells	Medium	Supported
epididymis	glandular cells	Medium	Supported
esophagus	squamous epithelial cells	Medium	Supported
fallopian tube	glandular cells	Medium	Supported
gallbladder	glandular cells	Medium	Supported
heart muscle	cardiomyocytes	Low	Supported
hippocampus	glial cells	Low	Supported
hippocampus	neuronal cells	Medium	Supported
kidney	cells in glomeruli	Medium	Supported
kidney	cells in tubules	Medium	Supported
liver	cholangiocytes	Low	Supported
lung	alveolar cells type II	Low	Supported
lung	endothelial cells	Medium	Supported
lung	macrophages	Medium	Supported
lymph node	germinal center cells	Medium	Supported
lymph node	non-germinal center cells	Medium	Supported
nasopharynx	respiratory epithelial cells	Medium	Supported
oral mucosa	squamous epithelial cells	Medium	Supported
ovary	follicle cells	Medium	Supported
ovary	ovarian stroma cells	Low	Supported
pancreas	exocrine glandular cells	Low	Supported
pancreas	pancreatic endocrine cells	Low	Supported
parathyroid gland	glandular cells	Medium	Supported
placenta	decidual cells	Medium	Supported
placenta	trophoblastic cells	Medium	Supported
prostate	glandular cells	Medium	Supported
rectum	glandular cells	Medium	Supported
salivary gland	glandular cells	Medium	Supported
seminal vesicle	glandular cells	Low	Supported
skeletal muscle	myocytes	Low	Supported
skin 1	endothelial cells	Medium	Supported
skin 2	cells in basal layer	Low	Supported
skin 2	cells in granular layer	Low	Supported
skin 2	cells in spinous layer	Low	Supported
skin 2	endothelial cells	High	Supported
skin 2	fibrohistiocytic cells	Medium	Supported
skin 2	hair follicles	Medium	Supported
skin 2	langerhans cells	Low	Supported
skin 2	lymphocytes	Medium	Supported
skin 2	melanocytes	Low	Supported
small intestine	glandular cells	Medium	Supported
smooth muscle	smooth muscle cells	Low	Supported
soft tissue 1	peripheral nerve	Low	Supported
soft tissue 2	fibroblasts	Low	Supported
soft tissue 2	peripheral nerve	Low	Supported
spleen	cells in red pulp	Medium	Supported
spleen	cells in white pulp	Medium	Supported
stomach 1	glandular cells	Medium	Supported
stomach 2	glandular cells	Medium	Supported
testis	elongated or late spermatids	Low	Supported
testis	round or early spermatids	Low	Supported
testis	sertoli cells	Medium	Supported
testis	spermatogonia cells	Low	Supported
thyroid gland	glandular cells	Medium	Supported
tonsil	germinal center cells	Medium	Supported
tonsil	non-germinal center cells	Medium	Supported
tonsil	squamous epithelial cells	Medium	Supported
urinary bladder	urothelial cells	Medium	Supported
vagina	squamous epithelial cells	Low	Supported

Summary of Q16543

Gene: CDC37, CDC37A
Protein: Hsp90 co-chaperone Cdc37

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q16543

Gene: CDC37, CDC37A Protein: Hsp90 co-chaperone Cdc37

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CDC37, CDC37A
Protein: Hsp90 co-chaperone Cdc37