MultifacetedProtDB - Bologna Biocomputing Group

Summary of Q16637

Gene: SMN1, SMN, SMNT;, SMN2, SMNC
Protein: Survival motor neuron protein

Protein family
Protein sequence
Protein function

Catalytic activity

The protein has not catalytic activity

Publications

Structure

Link to AlphaFold model

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PDB	Resolution (Å)	PDB name
1G5V		SOLUTION STRUCTURE OF THE TUDOR DOMAIN OF THE HUMAN SMN PROTEIN
1MHN	1.8	High resolution crystal structure of the SMN Tudor domain
2LEH		Solution structure of the core SMN-Gemin2 complex
4A4E		Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine
4A4G		Solution structure of SMN Tudor domain in complex with asymmetrically dimethylated arginine
4GLI	1.903	Crystal Structure of Human SMN YG-Dimer
4QQ6	1.75	Crystal Structure of tudor domain of SMN1 in complex with a small organic molecule
5XJL	2.5	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1/D2/F/E/G from Human
5XJQ	3.28	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2/F/E/G from Human
5XJR	3.12	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2/F/E/G from Human

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GO term

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GO ontology	GO term	GO description
Biological Process	GO:0006353	DNA-templated transcription termination
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0000245	spliceosomal complex assembly
Biological Process	GO:0000387	spliceosomal snRNP assembly
Cellular Component	GO:0015030	Cajal body
Cellular Component	GO:0097504	Gemini of coiled bodies
Cellular Component	GO:0032797	SMN complex
Cellular Component	GO:0034719	SMN-Sm protein complex
Cellular Component	GO:0030018	Z disc
Cellular Component	GO:0030424	axon

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InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

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Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Supported
appendix	glandular cells	Medium	Supported
appendix	lymphoid tissue	Medium	Supported
bone marrow	hematopoietic cells	High	Supported
breast	glandular cells	Medium	Supported
breast	myoepithelial cells	Medium	Supported
bronchus	respiratory epithelial cells	High	Supported
caudate	neuronal cells	High	Supported
cerebellum	Purkinje cells	Medium	Supported
cerebellum	cells in granular layer	Medium	Supported

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Disease