Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
4.2.1.152
Lyases;
Carbon-oxygen lyases;
Hydro-lyases;
hydroperoxy icosatetraenoate dehydratase
5.3.99.4
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases;
prostaglandin-I synthase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway |
| Biological Process | GO:0097190 | apoptotic signaling pathway |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0071347 | cellular response to interleukin-1 |
| Biological Process | GO:0071354 | cellular response to interleukin-6 |
| Biological Process | GO:0019371 | cyclooxygenase pathway |
| Biological Process | GO:0006690 | icosanoid metabolic process |
| Biological Process | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0045019 | negative regulation of nitric oxide biosynthetic process |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:1900119 | positive regulation of execution phase of apoptosis |
| Biological Process | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0106256 | hydroperoxy icosatetraenoate dehydratase activity |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0004497 | monooxygenase activity |
| Molecular Function | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| Molecular Function | GO:0008116 | prostaglandin-I synthase activity |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-197264 | Nicotinamide salvaging | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-211979 | Eicosanoids | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-211994 | Sterols are 12-hydroxylated by CYP8B1 | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Endoplasmic reticulum membrane | ECO:0000250 |
| HPO ID
|
HPO name |
|---|---|
| HP:0001426 | Multifactorial inheritance |
| HP:0004421 | Elevated systolic blood pressure |
| HP:0004972 | Elevated mean arterial pressure |
| HP:0005117 | Elevated diastolic blood pressure |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | glandular cells | Low | Enhanced |
| bone marrow | hematopoietic cells | Low | Enhanced |
| breast | glandular cells | Low | Enhanced |
| breast | myoepithelial cells | Low | Enhanced |
| bronchus | ciliated cells (cell body) | Medium | Enhanced |
| caudate | glial cells | Low | Enhanced |
| caudate | neuronal cells | Low | Enhanced |
| cerebellum | Purkinje cells | Medium | Enhanced |
| cerebral cortex | neuronal cells | Medium | Enhanced |
| cerebral cortex | neuropil | Low | Enhanced |
| cervix | glandular cells | Low | Enhanced |
| colon | endothelial cells | Low | Enhanced |
| colon | glandular cells | Medium | Enhanced |
| colon | peripheral nerve/ganglion | Medium | Enhanced |
| duodenum | glandular cells | Medium | Enhanced |
| endometrium 1 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | cells in endometrial stroma | Low | Enhanced |
| endometrium 2 | glandular cells | Low | Enhanced |
| epididymis | glandular cells | Low | Enhanced |
| esophagus | squamous epithelial cells | Low | Enhanced |
| fallopian tube | ciliated cells (ciliary rootlets) | Low | Enhanced |
| fallopian tube | ciliated cells (tip of cilia) | Low | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| heart muscle | cardiomyocytes | Low | Enhanced |
| hippocampus | glial cells | Low | Enhanced |
| hippocampus | neuronal cells | Low | Enhanced |
| kidney | cells in tubules | Medium | Enhanced |
| liver | cholangiocytes | Medium | Enhanced |
| liver | hepatocytes | Medium | Enhanced |
| lung | alveolar cells | Low | Enhanced |
| lung | macrophages | Medium | Enhanced |
| lymph node | germinal center cells | Medium | Enhanced |
| lymph node | non-germinal center cells | Low | Enhanced |
| nasopharynx | ciliated cells (cell body) | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Low | Enhanced |
| ovary | follicle cells | Medium | Enhanced |
| parathyroid gland | glandular cells | Medium | Enhanced |
| placenta | decidual cells | Low | Enhanced |
| placenta | trophoblastic cells | Low | Enhanced |
| prostate | glandular cells | Low | Enhanced |
| rectum | glandular cells | Low | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Low | Enhanced |
| skin 2 | epidermal cells | Low | Enhanced |
| small intestine | glandular cells | Low | Enhanced |
| smooth muscle | smooth muscle cells | Low | Enhanced |
| spleen | cells in red pulp | Low | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | Low | Enhanced |
| testis | Leydig cells | Medium | Enhanced |
| testis | elongated or late spermatids | Low | Enhanced |
| testis | pachytene spermatocytes | Low | Enhanced |
| testis | preleptotene spermatocytes | Low | Enhanced |
| testis | spermatogonia cells | High | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | non-germinal center cells | Low | Enhanced |
| tonsil | squamous epithelial cells | Low | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| essential hypertension, genetic | MONDO:0007781 | I10 | chapter9, Diseases of the circulatory system | OMIM:145500 |