Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
1.14.14.1
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor;
unspecific monooxygenase
4.2.1.152
Lyases;
Carbon-oxygen lyases;
Hydro-lyases;
hydroperoxy icosatetraenoate dehydratase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006304 | DNA modification |
| Biological Process | GO:0030325 | adrenal gland development |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0019369 | arachidonic acid metabolic process |
| Biological Process | GO:0042537 | benzene-containing compound metabolic process |
| Biological Process | GO:0043534 | blood vessel endothelial cell migration |
| Biological Process | GO:0048514 | blood vessel morphogenesis |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0071320 | cellular response to cAMP |
| Biological Process | GO:0071387 | cellular response to cortisol stimulus |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:0071373 | cellular response to luteinizing hormone stimulus |
| Biological Process | GO:0071407 | cellular response to organic cyclic compound |
| Biological Process | GO:0071393 | cellular response to progesterone stimulus |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0030199 | collagen fibril organization |
| Biological Process | GO:0043542 | endothelial cell migration |
| Biological Process | GO:0071603 | endothelial cell-cell adhesion |
| Biological Process | GO:0019373 | epoxygenase P450 pathway |
| Biological Process | GO:0008210 | estrogen metabolic process |
| Biological Process | GO:0044849 | estrous cycle |
| Biological Process | GO:0061548 | ganglion development |
| Biological Process | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| Biological Process | GO:0008584 | male gonad development |
| Biological Process | GO:0046466 | membrane lipid catabolic process |
| Biological Process | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| Biological Process | GO:0033629 | negative regulation of cell adhesion mediated by integrin |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0006809 | nitric oxide biosynthetic process |
| Biological Process | GO:0097267 | omega-hydroxylase P450 pathway |
| Biological Process | GO:2000573 | positive regulation of DNA biosynthetic process |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0046427 | positive regulation of receptor signaling pathway via JAK-STAT |
| Biological Process | GO:0014911 | positive regulation of smooth muscle cell migration |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| Biological Process | GO:2000377 | regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0046685 | response to arsenic-containing substance |
| Biological Process | GO:0071548 | response to dexamethasone |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0032354 | response to follicle-stimulating hormone |
| Biological Process | GO:0071680 | response to indole-3-methanol |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0061304 | retinal blood vessel morphogenesis |
| Biological Process | GO:0042574 | retinal metabolic process |
| Biological Process | GO:0042572 | retinol metabolic process |
| Biological Process | GO:0008202 | steroid metabolic process |
| Biological Process | GO:0016125 | sterol metabolic process |
| Biological Process | GO:0009404 | toxin metabolic process |
| Biological Process | GO:0002930 | trabecular meshwork development |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
| Molecular Function | GO:0070330 | aromatase activity |
| Molecular Function | GO:0101020 | estrogen 16-alpha-hydroxylase activity |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0106256 | hydroperoxy icosatetraenoate dehydratase activity |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0004497 | monooxygenase activity |
| Molecular Function | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-211976 | Endogenous sterols | Internal node | R-HSA-1430728 | Metabolism |
| R-HSA-2142670 | Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-2142816 | Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-5579000 | Defective CYP1B1 causes Glaucoma | Leaf | R-HSA-1643685 | Disease |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Endoplasmic reticulum membrane | ECO:0000250 | |
| Microsome membrane | ECO:0000250 | |
| Mitochondrion | ECO:0000250 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000486 | Strabismus |
| HP:0000501 | Glaucoma |
| HP:0000505 | Visual impairment |
| HP:0000523 | Subcapsular cataract |
| HP:0000525 | Abnormality iris morphology |
| HP:0000541 | Retinal detachment |
| HP:0000557 | Buphthalmos |
| HP:0000572 | Visual loss |
| HP:0000587 | Abnormal optic nerve morphology |
| HP:0000593 | Abnormal anterior chamber morphology |
| HP:0000603 | Central scotoma |
| HP:0000639 | Nystagmus |
| HP:0000659 | Peters anomaly |
| HP:0001052 | Nevus flammeus |
| HP:0001087 | Developmental glaucoma |
| HP:0001138 | Optic neuropathy |
| HP:0003593 | Infantile onset |
| HP:0007759 | Opacification of the corneal stroma |
| HP:0007854 | Glaucomatous visual field defect |
| HP:0007906 | Ocular hypertension |
| HP:0007957 | Corneal opacity |
| HP:0007994 | Peripheral visual field loss |
| HP:0008007 | Primary congenital glaucoma |
| HP:0008041 | Late onset congenital glaucoma |
| HP:0011003 | High myopia |
| HP:0011483 | Anterior synechiae of the anterior chamber |
| HP:0011484 | Posterior synechiae of the anterior chamber |
| HP:0011490 | Abnormal Descemet membrane morphology |
| HP:0011493 | Central opacification of the cornea |
| HP:0011496 | Corneal neovascularization |
| HP:0012108 | Open angle glaucoma |
| HP:0012511 | Temporal optic disc pallor |
| HP:0012636 | Retinal vein occlusion |
| HP:0012796 | Increased cup-to-disc ratio |
| HP:0025326 | Retinal arterial occlusion |
| HP:0031159 | Thinning of Descemet membrane |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | adipocytes | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | Low | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Low | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Low | Approved |
| gallbladder | glandular cells | Low | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | High | Approved |
| liver | hepatocytes | Low | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Medium | Approved |
| nasopharynx | respiratory epithelial cells | Low | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | decidual cells | Low | Approved |
| placenta | trophoblastic cells | Low | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | High | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | keratinocytes | Low | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | Medium | Approved |
| soft tissue 1 | fibroblasts | Low | Approved |
| soft tissue 2 | chondrocytes | Low | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| glaucoma 1- open angle- a | MONDO:0007664 | H40 | chapter7, Diseases of the eye and adnexa | OMIM:137750 | |
| glaucoma 3a | MONDO:0009277 | H40 | chapter7, Diseases of the eye and adnexa | OMIM:231300 | Orphanet:98976 |
| glaucoma 3a | MONDO:0009277 | H40 | chapter7, Diseases of the eye and adnexa | OMIM:231300 | Orphanet:98977 |
| glaucoma 3, primary infantile, b | MONDO:0010968 | Q15 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:600975 | |
| peters anomaly | MONDO:0011414 | Q13 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:604229 | Orphanet:708 |
| anterior segment dysgenesis 6 | MONDO:0015016 | Q13 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:617315 |