Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.6.1.64
Transferases;
Transferring nitrogenous groups;
Transaminases;
glutamine—phenylpyruvate transaminase
2.6.1.7
Transferases;
Transferring nitrogenous groups;
Transaminases;
kynurenine—oxoglutarate transaminase
4.4.1.13
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date);
cysteine-S-conjugate β-lyase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1W7L | 2.0 | Crystal structure of human kynurenine aminotransferase I |
| 1W7M | 2.7 | Crystal structure of human kynurenine aminotransferase I in complex with L-Phe |
| 1W7N | 2.9 | Crystal structure of human kynurenine aminotransferase I in PMP form |
| 3FVS | 1.5 | Human Kynurenine Aminotransferase I in complex with Glycerol |
| 3FVU | 1.55 | Crystal Structure of Human Kynurenine Aminotransferase I in Complex with Indole-3-acetic Acid |
| 3FVX | 1.5 | Human kynurenine aminotransferase I in complex with tris |
| 4WLH | 1.28 | High resolution crystal structure of human kynurenine aminotransferase-I bound to PLP cofactor |
| 4WLJ | 1.54 | High resolution crystal structure of human kynurenine aminotransferase-I in complex with aminooxyacetate |
| 4WP0 | 3.0 | Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0097053 | L-kynurenine catabolic process |
| Biological Process | GO:0009058 | biosynthetic process |
| Biological Process | GO:0070189 | kynurenine metabolic process |
| Biological Process | GO:0009617 | response to bacterium |
| Molecular Function | GO:0047804 | cysteine-S-conjugate beta-lyase activity |
| Molecular Function | GO:0047316 | glutamine-phenylpyruvate transaminase activity |
| Molecular Function | GO:0016212 | kynurenine-oxoglutarate transaminase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| InterPro
|
InterPro name |
|---|---|
| IPR004839 | Aminotransferase, class I/classII |
| IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| IPR015424 | Pyridoxal phosphate-dependent transferase |
| Pfam
|
Pfam name |
|---|---|
| PF00155 | Aminotransferase class I and II |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-71240 | Tryptophan catabolism | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-8964208 | Phenylalanine metabolism | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-8964539 | Glutamate and glutamine metabolism | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, cytosol | ECO:0000269 | PubMed:7883047 |