Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.6.1.64
Transferases;
Transferring nitrogenous groups;
Transaminases;
glutamine—phenylpyruvate transaminase
2.6.1.7
Transferases;
Transferring nitrogenous groups;
Transaminases;
kynurenine—oxoglutarate transaminase
4.4.1.13
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date);
cysteine-S-conjugate β-lyase
PDB | Resolution (Å) | PDB name |
---|---|---|
1W7L | 2.0 | Crystal structure of human kynurenine aminotransferase I |
1W7M | 2.7 | Crystal structure of human kynurenine aminotransferase I in complex with L-Phe |
1W7N | 2.9 | Crystal structure of human kynurenine aminotransferase I in PMP form |
3FVS | 1.5 | Human Kynurenine Aminotransferase I in complex with Glycerol |
3FVU | 1.55 | Crystal Structure of Human Kynurenine Aminotransferase I in Complex with Indole-3-acetic Acid |
3FVX | 1.5 | Human kynurenine aminotransferase I in complex with tris |
4WLH | 1.28 | High resolution crystal structure of human kynurenine aminotransferase-I bound to PLP cofactor |
4WLJ | 1.54 | High resolution crystal structure of human kynurenine aminotransferase-I in complex with aminooxyacetate |
4WP0 | 3.0 | Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0097053 | L-kynurenine catabolic process |
Biological Process | GO:0009058 | biosynthetic process |
Biological Process | GO:0070189 | kynurenine metabolic process |
Biological Process | GO:0009617 | response to bacterium |
Molecular Function | GO:0047804 | cysteine-S-conjugate beta-lyase activity |
Molecular Function | GO:0047316 | glutamine-phenylpyruvate transaminase activity |
Molecular Function | GO:0016212 | kynurenine-oxoglutarate transaminase activity |
Molecular Function | GO:0042803 | protein homodimerization activity |
Molecular Function | GO:0030170 | pyridoxal phosphate binding |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005739 | mitochondrion |
InterPro | InterPro name |
---|---|
IPR004839 | Aminotransferase, class I/classII |
IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
IPR015424 | Pyridoxal phosphate-dependent transferase |
Pfam | Pfam name |
---|---|
PF00155 | Aminotransferase class I and II |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-71240 | Tryptophan catabolism | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-8964208 | Phenylalanine metabolism | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-8964539 | Glutamate and glutamine metabolism | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm, cytosol | ECO:0000269 | PubMed:7883047 |