MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.11.1.2	Oxidoreductases; Acting on a peroxide as acceptor; Peroxidases; NADPH peroxidase
1.8.1.9	Oxidoreductases; Acting on a sulfur group of donors; With NAD+ or NADP+ as acceptor; thioredoxin-disulfide reductase

Structure

PDB	Resolution (Å)	PDB name
2CFY	2.7	Crystal structure of human thioredoxin reductase 1
2J3N	2.8	X-ray structure of human thioredoxin reductase 1
2ZZ0	2.8	Crystal structure of human thioredoxin reductase I (SeCys 498 Cys)
2ZZB	3.2	Crystal structure of human thioredoxin reductase I and terpyridine platinum(II)
2ZZC	2.6	Crystal structure of NADP(H):human thioredoxin reductase I
3QFA	2.2	Crystal structure of the human thioredoxin reductase-thioredoxin complex
3QFB	2.6	Crystal structure of the human thioredoxin reductase-thioredoxin complex
7X1R	3.9	Cryo-EM structure of human thioredoxin reductase bound by Au

GO term

GO ontology	GO term	GO description
Biological Process	GO:0008283	cell population proliferation
Biological Process	GO:0045454	cell redox homeostasis
Biological Process	GO:0001707	mesoderm formation
Biological Process	GO:0007165	signal transduction
Molecular Function	GO:0071949	FAD binding
Molecular Function	GO:0050137	NADPH peroxidase activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0004791	thioredoxin-disulfide reductase activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0001650	fibrillar center
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005654	nucleoplasm

InterPro / Pfam

InterPro	InterPro name
IPR002109	Glutaredoxin
IPR004099	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
IPR006338	Thioredoxin/glutathione reductase selenoprotein
IPR012999	Pyridine nucleotide-disulphide oxidoreductase, class I, active site
IPR016156	FAD/NAD-linked reductase, dimerisation domain superfamily
IPR023753	FAD/NAD(P)-binding domain
IPR036188	FAD/NAD(P)-binding domain superfamily
IPR036249	Thioredoxin-like superfamily
IPR046952	Glutathione reductase/thioredoxin reductase-like

Pfam	Pfam name
PF00462	Glutaredoxin
PF02852	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF07992	Pyridine nucleotide-disulphide oxidoreductase

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1989781	PPARA activates gene expression	Leaf	R-HSA-1430728	Metabolism
R-HSA-2408550	Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	Leaf	R-HSA-1430728	Metabolism
R-HSA-3299685	Detoxification of Reactive Oxygen Species	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	Leaf	R-HSA-1430728	Metabolism
R-HSA-5263617	Metabolism of ingested MeSeO2H into MeSeH	Leaf	R-HSA-1430728	Metabolism
R-HSA-5336415	Uptake and function of diphtheria toxin	Leaf	R-HSA-1643685	Disease
R-HSA-5628897	TP53 Regulates Metabolic Genes	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9818027	NFE2L2 regulating anti-oxidant/detoxification enzymes	Leaf	R-HSA-8953897	Cellular responses to stimuli

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:15199063
Cytoplasm	ECO:0000269	PubMed:18042542
Nucleus	ECO:0000269	PubMed:15199063

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Approved
adrenal gland	glandular cells	High	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Medium	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	adipocytes	Low	Approved
breast	glandular cells	Low	Approved
breast	myoepithelial cells	Low	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	High	Approved
cerebellum	Purkinje cells	High	Approved
cerebellum	cells in granular layer	Medium	Approved
cerebellum	cells in molecular layer	High	Approved
cerebral cortex	endothelial cells	Medium	Approved
cerebral cortex	glial cells	Medium	Approved
cerebral cortex	neuronal cells	High	Approved
cerebral cortex	neuropil	Low	Approved
cervix	glandular cells	Medium	Approved
cervix	squamous epithelial cells	Low	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	Medium	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 1	glandular cells	High	Approved
endometrium 2	cells in endometrial stroma	Medium	Approved
endometrium 2	glandular cells	High	Approved
epididymis	glandular cells	High	Approved
esophagus	squamous epithelial cells	Low	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	High	Approved
heart muscle	cardiomyocytes	Medium	Approved
hippocampus	glial cells	Low	Approved
hippocampus	neuronal cells	High	Approved
kidney	cells in glomeruli	Medium	Approved
kidney	cells in tubules	High	Approved
liver	cholangiocytes	High	Approved
liver	hepatocytes	Medium	Approved
lung	alveolar cells	Low	Approved
lung	macrophages	High	Approved
lymph node	germinal center cells	Medium	Approved
lymph node	non-germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
oral mucosa	squamous epithelial cells	Low	Approved
ovary	follicle cells	Medium	Approved
ovary	ovarian stroma cells	Low	Approved
pancreas	exocrine glandular cells	Medium	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
parathyroid gland	glandular cells	High	Approved
placenta	decidual cells	Medium	Approved
placenta	trophoblastic cells	High	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	High	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Medium	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	Medium	Approved
skin 1	fibroblasts	Medium	Approved
skin 1	keratinocytes	Medium	Approved
skin 1	melanocytes	Medium	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	Medium	Approved
smooth muscle	smooth muscle cells	Medium	Approved
soft tissue 1	fibroblasts	Medium	Approved
soft tissue 2	fibroblasts	Low	Approved
soft tissue 2	peripheral nerve	Low	Approved
spleen	cells in red pulp	High	Approved
spleen	cells in white pulp	Low	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	High	Approved
testis	cells in seminiferous ducts	Medium	Approved
thyroid gland	glandular cells	High	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Low	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	High	Approved
vagina	squamous epithelial cells	Low	Approved

Summary of Q16881

Gene: TXNRD1, GRIM12, KDRF
Protein: Thioredoxin reductase 1, cytoplasmic

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q16881

Gene: TXNRD1, GRIM12, KDRF Protein: Thioredoxin reductase 1, cytoplasmic

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: TXNRD1, GRIM12, KDRF
Protein: Thioredoxin reductase 1, cytoplasmic