MultifacetedProtDB - Bologna Biocomputing Group

Catalytic activity

EC number	EC number description
2.1.1.361	Transferases; Transferring one-carbon groups; Methyltransferases; [histone H4]-lysine20 N-methyltransferase
2.1.1.362	Transferases; Transferring one-carbon groups; Methyltransferases; [histone H4]-N-methyl-L-lysine20 N-methyltransferase

Publications

PDB	Resolution (Å)	PDB name
3S8P	1.85	Crystal Structure of the SET Domain of Human Histone-Lysine N-Methyltransferase SUV420H1 In Complex With S-Adenosyl-L-Methionine
5CPR	2.22	The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
5WBV	2.3	Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor

GO ontology	GO term	GO description
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0034772	histone H4-K20 dimethylation
Biological Process	GO:0007517	muscle organ development
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining
Biological Process	GO:0045830	positive regulation of isotype switching
Molecular Function	GO:1904047	S-adenosyl-L-methionine binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0042799	histone H4K20 methyltransferase activity
Molecular Function	GO:0140944	histone H4K20 monomethyltransferase activity
Molecular Function	GO:0140941	histone H4K20me methyltransferase activity
Molecular Function	GO:0042054	histone methyltransferase activity
Molecular Function	GO:0046872	metal ion binding
Cellular Component	GO:0000779	condensed chromosome, centromeric region
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus

InterPro	InterPro name
IPR001214	SET domain
IPR025790	Suv4-20 family, animal
IPR039977	Histone-lysine N-methyltransferase Suv4-20/Set9
IPR041938	Histone-lysine N-methyltransferase, N-terminal domain
IPR044424	KMT5B , SET domain
IPR046341	SET domain superfamily

Location	ECO term	Pubmed
Chromosome	ECO:0000250
Nucleus	ECO:0000269	PubMed:23720823

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000028	Cryptorchidism
HP:0000256	Macrocephaly
HP:0000286	Epicanthus
HP:0000348	High forehead
HP:0000403	Recurrent otitis media
HP:0000431	Wide nasal bridge
HP:0000718	Aggressive behavior
HP:0000729	Autistic behavior
HP:0000750	Delayed speech and language development
HP:0001249	Intellectual disability
HP:0001263	Global developmental delay
HP:0001344	Absent speech
HP:0001508	Failure to thrive
HP:0001762	Talipes equinovarus
HP:0001833	Long foot
HP:0002028	Chronic diarrhea
HP:0002033	Poor suck
HP:0002119	Ventriculomegaly
HP:0002373	Febrile seizure (within the age range of 3 months to 6 years)
HP:0003593	Infantile onset
HP:0005338	Sparse lateral eyebrow
HP:0007018	Attention deficit hyperactivity disorder
HP:0009765	Low hanging columella
HP:0010511	Long toe
HP:0011968	Feeding difficulties
HP:0012450	Chronic constipation
HP:0012520	Dilation of Virchow-Robin spaces
HP:0012741	Unilateral cryptorchidism
HP:0012810	Wide nasal base
HP:0031354	Sleep onset insomnia
HP:0032895	Febrile seizure outside the age of 3 months to 6 years
HP:0100023	Recurrent hand flapping
HP:0100033	Tics
HP:4000070	Fixated interests
HP:4000076	Use of another person's body to communicate