MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2G30	1.6	beta appendage of AP2 complexed with ARH peptide

GO term

GO ontology	GO term	GO description
Biological Process	GO:0042982	amyloid precursor protein metabolic process
Biological Process	GO:0071345	cellular response to cytokine stimulus
Biological Process	GO:0042632	cholesterol homeostasis
Biological Process	GO:0008203	cholesterol metabolic process
Biological Process	GO:0030301	cholesterol transport
Biological Process	GO:0034383	low-density lipoprotein particle clearance
Biological Process	GO:0090205	positive regulation of cholesterol metabolic process
Biological Process	GO:1905581	positive regulation of low-density lipoprotein particle clearance
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis
Biological Process	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation
Biological Process	GO:0031623	receptor internalization
Biological Process	GO:0006898	receptor-mediated endocytosis
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport
Biological Process	GO:0043393	regulation of protein binding
Biological Process	GO:1903076	regulation of protein localization to plasma membrane
Molecular Function	GO:0035650	AP-1 adaptor complex binding
Molecular Function	GO:0035612	AP-2 adaptor complex binding
Molecular Function	GO:0001540	amyloid-beta binding
Molecular Function	GO:0035615	clathrin adaptor activity
Molecular Function	GO:0030276	clathrin binding
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
Molecular Function	GO:0001784	phosphotyrosine residue binding
Molecular Function	GO:0035591	signaling adaptor activity
Molecular Function	GO:0030159	signaling receptor complex adaptor activity
Cellular Component	GO:0030424	axon
Cellular Component	GO:0009925	basal plasma membrane
Cellular Component	GO:0030669	clathrin-coated endocytic vesicle membrane
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0005883	neurofilament
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0055037	recycling endosome

InterPro / Pfam

InterPro	InterPro name
IPR006020	PTB/PI domain
IPR011993	PH-like domain superfamily

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-196791	Vitamin D (calciferol) metabolism	Leaf	R-HSA-1430728	Metabolism
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-8856828	Clathrin-mediated endocytosis	Internal node	R-HSA-5653656	Vesicle-mediated transport
R-HSA-8964026	Chylomicron clearance	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-8964038	LDL clearance	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-9758890	Transport of RCbl within the body	Leaf	R-HSA-1430728	Metabolism

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000799	Renal steatosis
HP:0000822	Hypertension
HP:0000991	Xanthomatosis
HP:0001138	Optic neuropathy
HP:0001397	Hepatic steatosis
HP:0001645	Sudden cardiac death
HP:0001653	Mitral regurgitation
HP:0001658	Myocardial infarction
HP:0001677	Coronary artery atherosclerosis
HP:0001681	Angina pectoris
HP:0001920	Renal artery stenosis
HP:0002094	Dyspnea
HP:0002155	Hypertriglyceridemia
HP:0002621	Atherosclerosis
HP:0002829	Arthralgia
HP:0003077	Hyperlipidemia
HP:0003124	Hypercholesterolemia
HP:0003141	Increased LDL cholesterol concentration
HP:0003563	Decreased LDL cholesterol concentration
HP:0004381	Supravalvular aortic stenosis
HP:0004416	Precocious atherosclerosis
HP:0004950	Peripheral arterial stenosis
HP:0004963	Calcification of the aorta
HP:0005162	Abnormal left ventricular function
HP:0005177	Premature arteriosclerosis
HP:0005181	Premature coronary artery atherosclerosis
HP:0006693	Myocardial steatosis
HP:0007201	Cerebral artery atherosclerosis
HP:0010874	Tendon xanthomatosis
HP:0012373	Abnormal eye physiology
HP:0012397	Aortic atherosclerotic lesion
HP:0012638	Abnormal nervous system physiology
HP:0030148	Heart murmur
HP:0030882	Coronary artery aneurysm
HP:0100261	Abnormal tendon morphology
HP:3000062	Abnormal internal carotid artery morphology

Summary of Q5SW96

Gene: LDLRAP1, ARH
Protein: Low density lipoprotein receptor adapter protein 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q5SW96

Gene: LDLRAP1, ARH Protein: Low density lipoprotein receptor adapter protein 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: LDLRAP1, ARH
Protein: Low density lipoprotein receptor adapter protein 1