MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.7.-.-	Oxidoreductases; Acting on other nitrogenous compounds as donors; ;

PDB	Resolution (Å)	PDB name
6FW2	1.78	Crystal Structure of human mARC1

GO ontology	GO term	GO description
Biological Process	GO:0070458	cellular detoxification of nitrogen compound
Biological Process	GO:0051410	detoxification of nitrogen compound
Biological Process	GO:0042126	nitrate metabolic process
Biological Process	GO:0006809	nitric oxide biosynthetic process
Molecular Function	GO:0030151	molybdenum ion binding
Molecular Function	GO:0043546	molybdopterin cofactor binding
Molecular Function	GO:0008940	nitrate reductase activity
Molecular Function	GO:0098809	nitrite reductase activity
Molecular Function	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors
Molecular Function	GO:0030170	pyridoxal phosphate binding
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:1903958	nitric-oxide synthase complex

InterPro	InterPro name
IPR005302	Molybdenum cofactor sulfurase, C-terminal
IPR005303	Molybdenum cofactor sulfurase, middle domain
IPR011037	Pyruvate kinase-like, insert domain superfamily

Pfam	Pfam name
PF03473	MOSC domain
PF03476	MOSC N-terminal beta barrel domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-211945	Phase I - Functionalization of compounds	Internal node	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Membrane	ECO:0000305
Mitochondrion outer membrane	ECO:0000269	PubMed:23086957

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Approved
adrenal gland	glandular cells	Low	Approved
appendix	glandular cells	High	Approved
bone marrow	hematopoietic cells	Low	Approved
breast	adipocytes	Medium	Approved
breast	glandular cells	Low	Approved
breast	myoepithelial cells	Low	Approved
bronchus	respiratory epithelial cells	Low	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	Low	Approved
cerebral cortex	neuronal cells	Low	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	Low	Approved
duodenum	glandular cells	High	Approved
endometrium 1	glandular cells	Medium	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	Low	Approved
esophagus	squamous epithelial cells	Medium	Approved
heart muscle	cardiomyocytes	Low	Approved
hippocampus	glial cells	Low	Approved
hippocampus	neuronal cells	Low	Approved
kidney	cells in tubules	Medium	Approved
liver	hepatocytes	Medium	Approved
lung	macrophages	Low	Approved
nasopharynx	respiratory epithelial cells	Low	Approved
placenta	trophoblastic cells	High	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	High	Approved
salivary gland	glandular cells	Low	Approved
seminal vesicle	glandular cells	Medium	Approved
small intestine	glandular cells	High	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Low	Approved
thyroid gland	glandular cells	High	Approved
tonsil	germinal center cells	Low	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	Low	Approved