Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.3.2.-
Transferases;
Acyltransferases;
Aminoacyltransferases;
2.3.2.27
Transferases;
Acyltransferases;
Aminoacyltransferases;
RING-type E3 ubiquitin transferase
3.6.4.-
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement;
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0042742 | defense response to bacterium |
| Biological Process | GO:0002376 | immune system process |
| Biological Process | GO:0140042 | lipid droplet formation |
| Biological Process | GO:0120323 | lipid ubiquitination |
| Biological Process | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway |
| Biological Process | GO:0070534 | protein K63-linked ubiquitination |
| Biological Process | GO:0051865 | protein autoubiquitination |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0019216 | regulation of lipid metabolic process |
| Biological Process | GO:0002040 | sprouting angiogenesis |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0098792 | xenophagy |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005730 | nucleolus |
| InterPro
|
InterPro name |
|---|---|
| IPR001841 | Zinc finger, RING-type |
| IPR003593 | AAA+ ATPase domain |
| IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| IPR018957 | Zinc finger, C3HC4 RING-type |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| IPR031248 | E3 ubiquitin-protein ligase RNF213 |
| IPR046439 | Zinc finger, RZ-type |
| Pfam
|
Pfam name |
|---|---|
| PF00097 | Zinc finger, C3HC4 type (RING finger) |
| PF20173 | Family of unknown function (DUF6539) |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-9635465 | Suppression of apoptosis | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Internal node | R-HSA-1643685 | Disease |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | Leaf | R-HSA-168256 | Immune System |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, cytosol | ECO:0000269 | PubMed:21799892 |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:30705059 |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:34012115 |
| Lipid droplet | ECO:0000269 | PubMed:30705059 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000007 | Autosomal recessive inheritance |
| HP:0001009 | Telangiectasia |
| HP:0001249 | Intellectual disability |
| HP:0001250 | Seizure |
| HP:0002119 | Ventriculomegaly |
| HP:0002326 | Transient ischemic attack |
| HP:0011834 | Moyamoya phenomenon |
| HP:0100659 | Abnormal cerebral vascular morphology |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Low | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Low | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | High | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | High | Approved |
| liver | hepatocytes | Low | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | Low | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Low | Approved |
| pancreas | exocrine glandular cells | Low | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | Low | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Low | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Low | Approved |
| skeletal muscle | myocytes | Low | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | keratinocytes | Low | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Medium | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | Medium | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Low | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| moyamoya disease 2 | MONDO:0011784 | I67 | chapter9, Diseases of the circulatory system | OMIM:607151 | |
| atypical coarctation of aorta | MONDO:0015446 | Q25 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | Orphanet:1456 |