Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
6.2.1.-
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
6.2.1.15
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
arachidonate—CoA ligase
6.2.1.3
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
long-chain-fatty-acid—CoA ligase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0090630 | activation of GTPase activity |
| Biological Process | GO:0051649 | establishment of localization in cell |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0015908 | fatty acid transport |
| Biological Process | GO:0044381 | glucose import in response to insulin stimulus |
| Biological Process | GO:1990379 | lipid transport across blood-brain barrier |
| Biological Process | GO:0044539 | long-chain fatty acid import into cell |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0015909 | long-chain fatty acid transport |
| Biological Process | GO:0001579 | medium-chain fatty acid transport |
| Biological Process | GO:0062003 | negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity |
| Biological Process | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0043588 | skin development |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
| Biological Process | GO:0042760 | very long-chain fatty acid catabolic process |
| Molecular Function | GO:0047676 | arachidonate-CoA ligase activity |
| Molecular Function | GO:0015245 | fatty acid transmembrane transporter activity |
| Molecular Function | GO:0005324 | long-chain fatty acid transporter activity |
| Molecular Function | GO:0004467 | long-chain fatty acid-CoA ligase activity |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:1901480 | oleate transmembrane transporter activity |
| Molecular Function | GO:0090434 | oleoyl-CoA ligase activity |
| Molecular Function | GO:0090433 | palmitoyl-CoA ligase activity |
| Molecular Function | GO:0031957 | very long-chain fatty acid-CoA ligase activity |
| Cellular Component | GO:0031526 | brush border membrane |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0005886 | plasma membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR000873 | AMP-dependent synthetase/ligase domain |
| IPR020845 | AMP-binding, conserved site |
| IPR022272 | Lipocalin family conserved site |
| IPR025110 | AMP-binding enzyme, C-terminal domain |
| IPR042099 | ANL, N-terminal domain |
| IPR045851 | AMP-binding enzyme, C-terminal domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00501 | AMP-binding enzyme |
| PF13193 | AMP-binding enzyme C-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-5619108 | Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) | Leaf | R-HSA-1643685 | Disease |
| R-HSA-804914 | Transport of fatty acids | Leaf | R-HSA-382551 | Transport of small molecules |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Endoplasmic reticulum membrane | ECO:0000305 | PubMed:22022213 |
| Endoplasmic reticulum membrane | ECO:0000305 | PubMed:24269233 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000953 | Hyperpigmentation of the skin |
| HP:0000989 | Pruritus |
| HP:0001019 | Erythroderma |
| HP:0001561 | Polyhydramnios |
| HP:0001622 | Premature birth |
| HP:0001880 | Eosinophilia |
| HP:0002099 | Asthma |
| HP:0002293 | Alopecia of scalp |
| HP:0002643 | Neonatal respiratory distress |
| HP:0003193 | Allergic rhinitis |
| HP:0007502 | Follicular hyperkeratosis |
| HP:0007503 | Generalized ichthyosis |
| HP:0007549 | Desquamation of skin soon after birth |
| HP:0008064 | Ichthyosis |
| HP:0011971 | Dermatographic urticaria |
| HP:0012768 | Neonatal asphyxia |
| HP:0025092 | Epidermal acanthosis |
| HP:0025724 | Caseous vernix-like desquamation |
| HP:0500093 | Food allergy |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Low | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | High | Approved |
| breast | glandular cells | Low | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cervix | glandular cells | High | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | High | Approved |
| esophagus | squamous epithelial cells | Low | Approved |
| fallopian tube | glandular cells | High | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Low | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| pancreas | exocrine glandular cells | High | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | Low | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | High | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Low | Approved |
| skin 1 | melanocytes | Low | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| soft tissue 2 | peripheral nerve | Medium | Approved |
| spleen | cells in red pulp | Medium | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| ichthyosis prematurity syndrome | MONDO:0012089 | J98 | chapter10, Diseases of the respiratory system | OMIM:608649 | Orphanet:88621 |