Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.7.1.5
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances;
acylpyruvate hydrolase
4.1.1.112
Lyases;
Carbon-carbon lyases;
Carboxy-lyases;
oxaloacetate decarboxylase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1SAW | 2.2 | X-ray structure of homo sapiens protein FLJ36880 |
| 6FOG | 1.94 | X-ray structure of homo sapiens Fumarylacetoacetate hydrolase domain containing protein 1 (FAHD1) in complex with inhibitor oxalate at 1.94A resolution. |
| 6FOH | 1.56 | X-ray structure of homo sapiens Fumarylacetoacetate hydrolase domain containing protein 1 (FAHD1) at 1.56A resolution. |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006090 | pyruvate metabolic process |
| Molecular Function | GO:0018773 | acetylpyruvate hydrolase activity |
| Molecular Function | GO:0047621 | acylpyruvate hydrolase activity |
| Molecular Function | GO:0034545 | fumarylpyruvate hydrolase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008948 | oxaloacetate decarboxylase activity |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-71403 | Citric acid cycle (TCA cycle) | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, cytosol | ECO:0000269 | PubMed:21878618 |
| Mitochondrion | ECO:0000269 | PubMed:21878618 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | High | Enhanced |
| appendix | endocrine cells | High | Enhanced |
| appendix | enterocytes | High | Enhanced |
| appendix | germinal center cells | Low | Enhanced |
| appendix | goblet cells | High | Enhanced |
| bone marrow | hematopoietic cells | Low | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| bronchus | respiratory epithelial cells | Medium | Enhanced |
| caudate | neuronal cells | Low | Enhanced |
| cerebellum | molecular layer cells - cytoplasm/membrane | High | Enhanced |
| cerebellum | processes in granular layer | High | Enhanced |
| cerebellum | processes in molecular layer | High | Enhanced |
| cerebellum | synaptic glomeruli - core | High | Enhanced |
| cerebral cortex | endothelial cells | Low | Enhanced |
| cerebral cortex | neuronal cells | Low | Enhanced |
| cerebral cortex | neuropil | Medium | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| cervix | squamous epithelial cells | Low | Enhanced |
| colon | endocrine cells | High | Enhanced |
| colon | endothelial cells | High | Enhanced |
| colon | enterocytes | High | Enhanced |
| colon | goblet cells | High | Enhanced |
| colon | mucosal lymphoid cells | Low | Enhanced |
| colon | peripheral nerve/ganglion | Medium | Enhanced |
| duodenum | endocrine cells | High | Enhanced |
| duodenum | enterocytes | High | Enhanced |
| duodenum | glands of Brunner | Low | Enhanced |
| duodenum | goblet cells | High | Enhanced |
| duodenum | paneth cells | Medium | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | glandular cells | High | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| esophagus | squamous epithelial cells | Medium | Enhanced |
| fallopian tube | glandular cells | Medium | Enhanced |
| gallbladder | glandular cells | High | Enhanced |
| heart muscle | cardiomyocytes | Medium | Enhanced |
| hippocampus | neuronal cells | Low | Enhanced |
| kidney | collecting ducts | Medium | Enhanced |
| kidney | distal tubules | High | Enhanced |
| kidney | proximal tubules (cell body) | High | Enhanced |
| liver | cholangiocytes | Medium | Enhanced |
| liver | hepatocytes | Medium | Enhanced |
| lung | alveolar cells type I | High | Enhanced |
| lung | endothelial cells | Medium | Enhanced |
| nasopharynx | respiratory epithelial cells | High | Enhanced |
| oral mucosa | squamous epithelial cells | Low | Enhanced |
| pancreas | exocrine glandular cells | Medium | Enhanced |
| pancreas | pancreatic endocrine cells | Medium | Enhanced |
| parathyroid gland | glandular cells | High | Enhanced |
| placenta | decidual cells | Low | Enhanced |
| placenta | trophoblastic cells | Medium | Enhanced |
| prostate | glandular cells | Medium | Enhanced |
| rectum | endocrine cells | High | Enhanced |
| rectum | endothelial cells | High | Enhanced |
| rectum | enterocytes | High | Enhanced |
| rectum | goblet cells | High | Enhanced |
| rectum | mucosal lymphoid cells | Low | Enhanced |
| salivary gland | glandular cells | Medium | Enhanced |
| seminal vesicle | glandular cells | High | Enhanced |
| skin 1 | endothelial cells | Medium | Enhanced |
| skin 1 | melanocytes | Low | Enhanced |
| skin 2 | cells in basal layer | Medium | Enhanced |
| skin 2 | endothelial cells | High | Enhanced |
| skin 2 | hair follicles | Low | Enhanced |
| skin 2 | melanocytes | High | Enhanced |
| small intestine | endocrine cells | High | Enhanced |
| small intestine | enterocytes | High | Enhanced |
| small intestine | goblet cells | High | Enhanced |
| small intestine | paneth cells | High | Enhanced |
| soft tissue 2 | peripheral nerve | Low | Enhanced |
| spleen | cells in red pulp | Low | Enhanced |
| spleen | cells in white pulp | Low | Enhanced |
| stomach 1 | glandular cells | High | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | Leydig cells | Medium | Enhanced |
| testis | sertoli cells | Medium | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | Medium | Enhanced |
| urinary bladder | urothelial cells | High | Enhanced |
| vagina | squamous epithelial cells | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|