MultifacetedProtDB - Bologna Biocomputing Group

Catalytic activity

EC number	EC number description
3.1.6.1	Hydrolases; Acting on ester bonds; Sulfuric-ester hydrolases; arylsulfatase (type I)
3.1.6.18	Hydrolases; Acting on ester bonds; Sulfuric-ester hydrolases; glucuronate-2-sulfatase

Publications

GO ontology	GO term	GO description
Molecular Function	GO:0004065	arylsulfatase activity
Molecular Function	GO:0015024	glucuronate-2-sulfatase activity
Molecular Function	GO:0046872	metal ion binding
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005764	lysosome

InterPro	InterPro name
IPR000917	Sulfatase, N-terminal
IPR017850	Alkaline-phosphatase-like, core domain superfamily

Pfam	Pfam name
PF00884	Sulfatase

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1660662	Glycosphingolipid metabolism	Leaf	R-HSA-1430728	Metabolism
R-HSA-1663150	The activation of arylsulfatases	Leaf	R-HSA-392499	Metabolism of proteins

Location	ECO term	Pubmed
Lysosome	ECO:0000269	PubMed:23986440
Secreted	ECO:0000269	PubMed:23986440

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000280	Coarse facial features
HP:0000343	Long philtrum
HP:0000431	Wide nasal bridge
HP:0000687	Widely spaced teeth
HP:0000699	Diastema
HP:0000787	Nephrolithiasis
HP:0000885	Broad ribs
HP:0000916	Broad clavicles
HP:0000926	Platyspondyly
HP:0001385	Hip dysplasia
HP:0001650	Aortic valve stenosis
HP:0001659	Aortic regurgitation
HP:0001712	Left ventricular hypertrophy
HP:0002650	Scoliosis
HP:0002857	Genu valgum
HP:0003307	Hyperlordosis
HP:0003521	Disproportionate short-trunk short stature
HP:0004568	Beaking of vertebral bodies
HP:0005121	Posterior scalloping of vertebral bodies
HP:0008301	Dermatan sulfate excretion in urine
HP:0008833	Irregular acetabular roof
HP:0010807	Open bite
HP:0011463	Childhood onset
HP:0012307	Spatulate ribs
HP:0031568	Thickened aortic valve cusp
HP:0100832	Vitreous floaters

Tissue	Cell type	Expression level	Reliability
appendix	glandular cells	Low	Approved
breast	glandular cells	Medium	Approved
bronchus	ciliated cells (ciliary rootlets)	Medium	Approved
cerebral cortex	glial cells	Medium	Approved
colon	glandular cells	Low	Approved
duodenum	glandular cells	High	Approved
endometrium 1	glandular cells	High	Approved
epididymis	glandular cells	Medium	Approved
fallopian tube	ciliated cells (cell body)	Medium	Approved
gallbladder	glandular cells	Medium	Approved
kidney	cells in tubules	High	Approved
ovary	follicle cells	Low	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	trophoblastic cells	Low	Approved
rectum	glandular cells	Low	Approved
salivary gland	glandular cells	Low	Approved
small intestine	glandular cells	High	Approved
soft tissue 1	chondrocytes	Medium	Approved
stomach 1	glandular cells	Low	Approved
stomach 2	glandular cells	Low	Approved
testis	elongated or late spermatids	Low	Approved
testis	sertoli cells	High	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	Low	Approved