MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.11.1	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; non-specific serine/threonine protein kinase
3.1.26.-	Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters;

GO ontology	GO term	GO description
Biological Process	GO:0036498	IRE1-mediated unfolded protein response
Biological Process	GO:0030263	apoptotic chromosome condensation
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0043507	positive regulation of JUN kinase activity
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0016075	rRNA catabolic process
Biological Process	GO:0034976	response to endoplasmic reticulum stress
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004521	RNA endonuclease activity
Molecular Function	GO:0004519	endonuclease activity
Molecular Function	GO:0000287	magnesium ion binding
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0051082	unfolded protein binding
Cellular Component	GO:1990604	IRE1-TRAF2-ASK1 complex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment

InterPro	InterPro name
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR010513	KEN domain
IPR011009	Protein kinase-like domain superfamily
IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR018391	Pyrrolo-quinoline quinone beta-propeller repeat
IPR038357	KEN domain superfamily
IPR045133	Serine/threonine-protein kinase/endoribonuclease IRE1/2-like

Pfam	Pfam name
PF00069	Protein kinase domain
PF06479	Ribonuclease 2-5A

Location	ECO term	Pubmed
Endoplasmic reticulum membrane	ECO:0000269	PubMed:11175748

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Approved
appendix	glandular cells	High	Approved
breast	glandular cells	Low	Approved
caudate	neuronal cells	Low	Approved
cerebellum	Purkinje cells	Low	Approved
cerebellum	cells in granular layer	Low	Approved
cerebral cortex	glial cells	Low	Approved
cerebral cortex	neuropil	Low	Approved
colon	glandular cells	High	Approved
colon	peripheral nerve/ganglion	Medium	Approved
duodenum	glandular cells	High	Approved
epididymis	glandular cells	Low	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Low	Approved
hippocampus	glial cells	Low	Approved
hippocampus	neuronal cells	Low	Approved
kidney	cells in glomeruli	Low	Approved
kidney	cells in tubules	Low	Approved
lung	macrophages	Low	Approved
lymph node	non-germinal center cells	Low	Approved
pancreas	exocrine glandular cells	Low	Approved
pancreas	pancreatic endocrine cells	Low	Approved
parathyroid gland	glandular cells	Low	Approved
placenta	trophoblastic cells	Low	Approved
rectum	glandular cells	High	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Low	Approved
skeletal muscle	myocytes	Low	Approved
small intestine	glandular cells	High	Approved
spleen	cells in white pulp	Low	Approved
stomach 1	glandular cells	High	Approved
stomach 2	glandular cells	High	Approved
testis	Leydig cells	Medium	Approved
testis	round or early spermatids	High	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Medium	Approved