Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
2.7.11.26
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
tau-protein kinase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3IEC | 2.2 | Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates |
| 5EAK | 2.8 | Optimization of Microtubule Affinity Regulating Kinase (MARK) Inhibitors with Improved Physical Properties |
| 5KZ7 | 3.2 | Mark2 complex with 7-[(1S)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3-pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one |
| 5KZ8 | 3.21 | Mark2 complex with 7-[(1S)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3-pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0016055 | Wnt signaling pathway |
| Biological Process | GO:0032147 | activation of protein kinase activity |
| Biological Process | GO:0000422 | autophagy of mitochondrion |
| Biological Process | GO:0061564 | axon development |
| Biological Process | GO:0030010 | establishment of cell polarity |
| Biological Process | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape |
| Biological Process | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0051646 | mitochondrion localization |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
| Biological Process | GO:0018107 | peptidyl-threonine phosphorylation |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0046777 | protein autophosphorylation |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0050770 | regulation of axonogenesis |
| Biological Process | GO:0051493 | regulation of cytoskeleton organization |
| Biological Process | GO:1904526 | regulation of microtubule binding |
| Biological Process | GO:0070507 | regulation of microtubule cytoskeleton organization |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0030295 | protein kinase activator activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0048156 | tau protein binding |
| Molecular Function | GO:0050321 | tau-protein kinase activity |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0097427 | microtubule bundle |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR000719 | Protein kinase domain |
| IPR001772 | Kinase associated domain 1 (KA1) |
| IPR008271 | Serine/threonine-protein kinase, active site |
| IPR011009 | Protein kinase-like domain superfamily |
| IPR015940 | Ubiquitin-associated domain |
| IPR017441 | Protein kinase, ATP binding site |
| IPR028375 | KA1 domain/Ssp2, C-terminal |
| Pfam
|
Pfam name |
|---|---|
| PF00069 | Protein kinase domain |
| PF00627 | UBA/TS-N domain |
| PF02149 | Kinase associated domain 1 |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ||
| Cell projection, dendrite | ECO:0000269 | PubMed:23666762 |
| Cytoplasm | ECO:0000269 | PubMed:23666762 |
| Cytoplasm | ||
| Cytoplasm, cytoskeleton | ||
| Lateral cell membrane |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | Low | Approved |
| appendix | glandular cells | High | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | basal cells | Medium | Approved |
| bronchus | ciliated cells (cell body) | Medium | Approved |
| bronchus | ciliated cells (ciliary rootlets) | Medium | Approved |
| bronchus | ciliated cells (tip of cilia) | Low | Approved |
| bronchus | goblet cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | High | Approved |
| cerebellum | cells in molecular layer | Low | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | High | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | Low | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Low | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | ciliated cells (cell body) | Medium | Approved |
| fallopian tube | ciliated cells (ciliary rootlets) | Medium | Approved |
| fallopian tube | ciliated cells (tip of cilia) | Low | Approved |
| fallopian tube | non-ciliated cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in tubules | High | Approved |
| liver | hepatocytes | Low | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | basal cells | Low | Approved |
| nasopharynx | ciliated cells (cell body) | Medium | Approved |
| nasopharynx | goblet cells | Medium | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Low | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | keratinocytes | Low | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| soft tissue 1 | peripheral nerve | Low | Approved |
| soft tissue 2 | chondrocytes | Medium | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | Medium | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | elongated or late spermatids | Low | Approved |
| testis | spermatogonia cells | Low | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | non-germinal center cells | Low | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Low | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|