Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
1.1.1.10
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
L-xylulose reductase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0042732 | D-xylose metabolic process |
| Biological Process | GO:0006739 | NADP metabolic process |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0019640 | glucuronate catabolic process to xylulose 5-phosphate |
| Biological Process | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0005997 | xylulose metabolic process |
| Molecular Function | GO:0050038 | L-xylulose reductase (NADP+) activity |
| Molecular Function | GO:0004090 | carbonyl reductase (NADPH) activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0005881 | cytoplasmic microtubule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-5661270 | Formation of xylulose-5-phosphate | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-5662853 | Essential pentosuria | Leaf | R-HSA-1643685 | Disease |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Membrane | ECO:0000250 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0003110 | Abnormality of urine homeostasis |
| HP:0011013 | Abnormal circulating carbohydrate concentration |
| HP:0011021 | Abnormality of circulating enzyme level |
| HP:0031979 | Abnormal urine carbohydrate level |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | glandular cells | Low | Enhanced |
| bone marrow | hematopoietic cells | Low | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| breast | myoepithelial cells | Medium | Enhanced |
| bronchus | basal cells | High | Enhanced |
| cerebral cortex | neuropil | Medium | Enhanced |
| cervix | squamous epithelial cells | Medium | Enhanced |
| colon | endothelial cells | Low | Enhanced |
| colon | glandular cells | Medium | Enhanced |
| colon | peripheral nerve/ganglion | Low | Enhanced |
| duodenum | glandular cells | Medium | Enhanced |
| endometrium 1 | glandular cells | Low | Enhanced |
| endometrium 2 | glandular cells | Low | Enhanced |
| epididymis | glandular cells | High | Enhanced |
| esophagus | squamous epithelial cells | Medium | Enhanced |
| fallopian tube | ciliated cells (cell body) | Low | Enhanced |
| fallopian tube | ciliated cells (ciliary rootlets) | Low | Enhanced |
| fallopian tube | ciliated cells (tip of cilia) | Low | Enhanced |
| fallopian tube | non-ciliated cells | Medium | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| heart muscle | cardiomyocytes | Low | Enhanced |
| kidney | distal tubules | Medium | Enhanced |
| kidney | proximal tubules (cell body) | Medium | Enhanced |
| liver | hepatocytes | High | Enhanced |
| lung | macrophages | Medium | Enhanced |
| nasopharynx | basal cells | High | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| ovary | follicle cells | Medium | Enhanced |
| parathyroid gland | glandular cells | Medium | Enhanced |
| placenta | decidual cells | Medium | Enhanced |
| placenta | trophoblastic cells | Medium | Enhanced |
| prostate | glandular cells | Medium | Enhanced |
| rectum | glandular cells | Medium | Enhanced |
| salivary gland | glandular cells | Low | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Low | Enhanced |
| skin 1 | cells in basal layer | Medium | Enhanced |
| skin 1 | cells in spinous layer | Low | Enhanced |
| skin 1 | fibrohistiocytic cells | Low | Enhanced |
| skin 2 | cells in basal layer | Medium | Enhanced |
| skin 2 | cells in spinous layer | Low | Enhanced |
| skin 2 | endothelial cells | Low | Enhanced |
| skin 2 | sebaceous glands | Low | Enhanced |
| small intestine | glandular cells | Medium | Enhanced |
| smooth muscle | smooth muscle cells | Low | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | Leydig cells | Medium | Enhanced |
| testis | cells in seminiferous ducts | Medium | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | Medium | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| vagina | squamous epithelial cells | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| pentosuria | MONDO:0009846 | E74 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:260800 | Orphanet:2843 |