Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
1.1.2.4
Oxidoreductases;
Acting on the CH-OH group of donors;
With a cytochrome as acceptor;
D-lactate dehydrogenase (cytochrome)
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:1903457 | lactate catabolic process |
| Molecular Function | GO:0004458 | D-lactate dehydrogenase (cytochrome) activity |
| Molecular Function | GO:0008720 | D-lactate dehydrogenase activity |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| InterPro
|
InterPro name |
|---|---|
| IPR004113 | FAD-binding oxidoreductase/transferase, type 4, C-terminal |
| IPR006094 | FAD linked oxidase, N-terminal |
| IPR016164 | FAD-linked oxidase-like, C-terminal |
| IPR016166 | FAD-binding domain, PCMH-type |
| IPR016167 | FAD-binding, type PCMH, subdomain 1 |
| IPR016169 | FAD-binding, type PCMH, subdomain 2 |
| IPR016171 | Vanillyl-alcohol oxidase, C-terminal subdomain 2 |
| IPR036318 | FAD-binding, type PCMH-like superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF01565 | FAD binding domain |
| PF02913 | FAD linked oxidases, C-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1268020 | Mitochondrial protein import | Leaf | R-HSA-9609507 | Protein localization |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Mitochondrion | ECO:0000250 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000023 | Inguinal hernia |
| HP:0000252 | Microcephaly |
| HP:0000494 | Downslanted palpebral fissures |
| HP:0000526 | Aniridia |
| HP:0001249 | Intellectual disability |
| HP:0003648 | Lacticaciduria |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | glandular cells | High | Enhanced |
| appendix | lymphoid tissue | Low | Enhanced |
| bone marrow | hematopoietic cells | Low | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| breast | myoepithelial cells | Low | Enhanced |
| bronchus | respiratory epithelial cells | High | Enhanced |
| caudate | neuronal cells | Low | Enhanced |
| cerebellum | Purkinje cells | Low | Enhanced |
| cerebral cortex | endothelial cells | Low | Enhanced |
| cerebral cortex | neuronal cells | Low | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| cervix | squamous epithelial cells | Low | Enhanced |
| colon | endothelial cells | Low | Enhanced |
| colon | glandular cells | High | Enhanced |
| colon | peripheral nerve/ganglion | Medium | Enhanced |
| duodenum | glandular cells | High | Enhanced |
| endometrium 1 | cells in endometrial stroma | Low | Enhanced |
| endometrium 1 | glandular cells | Low | Enhanced |
| endometrium 2 | glandular cells | Medium | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| esophagus | squamous epithelial cells | Medium | Enhanced |
| fallopian tube | glandular cells | High | Enhanced |
| gallbladder | glandular cells | High | Enhanced |
| heart muscle | cardiomyocytes | High | Enhanced |
| hippocampus | neuronal cells | Low | Enhanced |
| kidney | cells in glomeruli | Low | Enhanced |
| kidney | cells in tubules | High | Enhanced |
| liver | cholangiocytes | Low | Enhanced |
| liver | hepatocytes | Medium | Enhanced |
| lung | alveolar cells | Medium | Enhanced |
| lung | macrophages | Medium | Enhanced |
| lymph node | germinal center cells | Low | Enhanced |
| lymph node | non-germinal center cells | Low | Enhanced |
| nasopharynx | respiratory epithelial cells | High | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| ovary | follicle cells | Low | Enhanced |
| ovary | ovarian stroma cells | Low | Enhanced |
| pancreas | exocrine glandular cells | Medium | Enhanced |
| pancreas | pancreatic endocrine cells | Low | Enhanced |
| parathyroid gland | glandular cells | Medium | Enhanced |
| placenta | trophoblastic cells | Low | Enhanced |
| prostate | glandular cells | Medium | Enhanced |
| rectum | glandular cells | High | Enhanced |
| salivary gland | glandular cells | Medium | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Medium | Enhanced |
| skin 1 | Langerhans | Low | Enhanced |
| skin 1 | fibroblasts | Low | Enhanced |
| skin 1 | keratinocytes | Low | Enhanced |
| skin 1 | melanocytes | Low | Enhanced |
| skin 2 | epidermal cells | Medium | Enhanced |
| small intestine | glandular cells | High | Enhanced |
| smooth muscle | smooth muscle cells | Low | Enhanced |
| soft tissue 1 | chondrocytes | Medium | Enhanced |
| soft tissue 1 | fibroblasts | Low | Enhanced |
| soft tissue 1 | peripheral nerve | Low | Enhanced |
| soft tissue 2 | chondrocytes | Medium | Enhanced |
| soft tissue 2 | fibroblasts | Low | Enhanced |
| soft tissue 2 | peripheral nerve | Low | Enhanced |
| spleen | cells in red pulp | Low | Enhanced |
| spleen | cells in white pulp | Low | Enhanced |
| stomach 1 | glandular cells | High | Enhanced |
| stomach 2 | glandular cells | High | Enhanced |
| testis | Leydig cells | Low | Enhanced |
| testis | sertoli cells | Low | Enhanced |
| testis | spermatogonia cells | High | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | Low | Enhanced |
| tonsil | non-germinal center cells | Low | Enhanced |
| tonsil | squamous epithelial cells | Medium | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| vagina | squamous epithelial cells | Low | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| lactic aciduria due to d-lactic acid | MONDO:0009505 | - | - | OMIM:245450 |