MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.3.1.-	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups;
2.3.1.286	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; protein acetyllysine N-acetyltransferase

Structure

PDB	Resolution (Å)	PDB name
1J8F	1.7	HUMAN SIRT2 HISTONE DEACETYLASE
3ZGO	1.63	Re-refined structure of the human Sirt2 apoform
3ZGV	2.27	Structure of human SIRT2 in complex with ADP-ribose
4L3O	2.518	Crystal Structure of SIRT2 in complex with the macrocyclic peptide S2iL5
4R8M	2.1	Human SIRT2 crystal structure in complex with BHJH-TM1
4RMG	1.88	Human Sirt2 in complex with SirReal2 and NAD+
4RMH	1.42	Human Sirt2 in complex with SirReal2 and Ac-Lys-H3 peptide
4RMI	1.45	Human Sirt2 in complex with SirReal1 and Ac-Lys-OTC peptide
4RMJ	1.87	Human Sirt2 in complex with ADP ribose and nicotinamide
4X3O	1.5	Sirt2 in complex with a myristoyl peptide
4X3P	1.8	Sirt2 in complex with a myristoyl peptide
4Y6L	1.6	Human SIRT2 in complex with myristoylated peptide (H3K9myr)
4Y6O	1.6	Human SIRT2 in complex with myristoylated peptide (TNF-alphaK20myr)
4Y6Q	1.9	Human SIRT2 in complex with 2-O-myristoyl-ADP-ribose
5D7O	1.63	Crystal structure of Sirt2-ADPR at an improved resolution
5D7P	1.76	Crystal structure of human Sirt2 in complex with ADPR and EX-243
5D7Q	2.01	Crystal structure of human Sirt2 in complex with ADPR and CHIC35
5DY4	1.77	Crystal structure of human Sirt2 in complex with a brominated 2nd generation SirReal inhibitor and NAD+
5DY5	1.95	Crystal structure of human Sirt2 in complex with a SirReal probe fragment
5FYQ	3.0	Sirt2 in complex with a 13-mer trifluoroacetylated Ran peptide
5G4C	2.1	Human SIRT2 catalyse short chain fatty acyl lysine
5MAR	1.89	Structure of human SIRT2 in complex with 1,2,4-Oxadiazole inhibitor and ADP ribose.
5MAT	2.069	Structure of human Sirtuin 2 in complex with a selective thienopyrimidinone based inhibitor
5Y0Z	2.0	Human SIRT2 in complex with a specific inhibitor, NPD11033
5Y5N	2.3	Crystal structure of human Sirtuin 2 in complex with a selective inhibitor
5YQL	1.601	Crystal structure of Sirt2 in complex with selective inhibitor A2I
5YQM	1.735	Crystal structure of Sirt2 in complex with selective inhibitor A29
5YQN	1.6	Crystal structure of Sirt2 in complex with selective inhibitor L55
5YQO	1.483	Crystal structure of Sirt2 in complex with selective inhibitor L5C
6L65	1.8	Sirtuin 2 protein with H3K18 myristoylated peptide
6L66	2.169	Sirtuin 2 protein with H3K18 myristoylated peptide and intact NAD molecule
6L71	2.109	Sirtuin 2 demyristoylation native intermediate I & II mixture
6L72	2.501	Sirtuin 2 demyristoylation native final product
6NR0	2.45	SIRT2(56-356) with covalent intermediate between mechanism-based inhibitor Glucose-TM-1beta and 1'-SH ADP-ribose
6QCN	2.23	Human Sirt2 in complex with ADP-ribose and the inhibitor quercetin
7BOS	1.7	Human SIRT2 in complex with myristoyl thiourea inhibitor, No.13
7BOT	1.7	Human SIRT2 in complex with myristoyl thiourea inhibitor, No.23

GO term

GO ontology	GO term	GO description
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly
Biological Process	GO:0006914	autophagy
Biological Process	GO:0051301	cell division
Biological Process	GO:0044242	cellular lipid catabolic process
Biological Process	GO:0061433	cellular response to caloric restriction
Biological Process	GO:0071872	cellular response to epinephrine stimulus
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0034599	cellular response to oxidative stress
Biological Process	GO:0040029	epigenetic regulation of gene expression
Biological Process	GO:0031507	heterochromatin formation
Biological Process	GO:0016575	histone deacetylation
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0051321	meiotic cell cycle
Biological Process	GO:0007084	mitotic nuclear membrane reassembly
Biological Process	GO:0022011	myelination in peripheral nervous system
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly
Biological Process	GO:0010507	negative regulation of autophagy
Biological Process	GO:0045599	negative regulation of fat cell differentiation
Biological Process	GO:0070446	negative regulation of oligodendrocyte progenitor proliferation
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation
Biological Process	GO:0042177	negative regulation of protein catabolic process
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process
Biological Process	GO:0045843	negative regulation of striated muscle tissue development
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process	GO:0034983	peptidyl-lysine deacetylation
Biological Process	GO:0043388	positive regulation of DNA binding
Biological Process	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore
Biological Process	GO:0051781	positive regulation of cell division
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis
Biological Process	GO:0045723	positive regulation of fatty acid biosynthetic process
Biological Process	GO:0045836	positive regulation of meiotic nuclear division
Biological Process	GO:1900195	positive regulation of oocyte maturation
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process	GO:2000777	positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0006476	protein deacetylation
Biological Process	GO:0000183	rDNA heterochromatin formation
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0007096	regulation of exit from mitosis
Biological Process	GO:0031641	regulation of myelination
Biological Process	GO:0042325	regulation of phosphorylation
Biological Process	GO:0051775	response to redox state
Biological Process	GO:0021762	substantia nigra development
Biological Process	GO:0031509	subtelomeric heterochromatin formation
Biological Process	GO:0090042	tubulin deacetylation
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity
Molecular Function	GO:0070403	NAD+ binding
Molecular Function	GO:0046970	NAD-dependent histone H4K16 deacetylase activity
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity
Molecular Function	GO:0140774	NAD-dependent protein depalmitoylase activity
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0035035	histone acetyltransferase binding
Molecular Function	GO:0004407	histone deacetylase activity
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0033558	protein lysine deacetylase activity
Molecular Function	GO:0042903	tubulin deacetylase activity
Molecular Function	GO:0043130	ubiquitin binding
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0043220	Schmidt-Lanterman incisure
Cellular Component	GO:0005814	centriole
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005677	chromatin silencing complex
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0000781	chromosome, telomeric region
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0097386	glial cell projection
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0000792	heterochromatin
Cellular Component	GO:0044224	juxtaparanode region of axon
Cellular Component	GO:0043219	lateral loop
Cellular Component	GO:0072687	meiotic spindle
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0030496	midbody
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0043209	myelin sheath
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0033010	paranodal junction
Cellular Component	GO:0033270	paranode region of axon
Cellular Component	GO:0043204	perikaryon
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0005819	spindle

InterPro	InterPro name
IPR003000	Sirtuin family
IPR017328	Sirtuin, class I
IPR026590	Sirtuin family, catalytic core domain
IPR026591	Sirtuin, catalytic core small domain superfamily
IPR029035	DHS-like NAD/FAD-binding domain superfamily

Location	ECO term	Pubmed
Cell projection	ECO:0000250
Cell projection, growth cone	ECO:0000250
Chromosome	ECO:0000269	PubMed:16648462
Chromosome	ECO:0000269	PubMed:23468428
Cytoplasm	ECO:0000269	PubMed:12697818
Cytoplasm	ECO:0000269	PubMed:16079181
Cytoplasm	ECO:0000269	PubMed:16648462
Cytoplasm	ECO:0000269	PubMed:17726514
Cytoplasm	ECO:0000269	PubMed:20543840
Cytoplasm	ECO:0000269	PubMed:23908241
Cytoplasm	ECO:0000269	PubMed:24177535
Cytoplasm	ECO:0000269	PubMed:24681946
Cytoplasm, cytoskeleton	ECO:0000269	PubMed:12620231
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	ECO:0000269	PubMed:17488717
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	ECO:0000269	PubMed:17726514
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole	ECO:0000269	PubMed:17726514
Cytoplasm, cytoskeleton, spindle	ECO:0000269	PubMed:17488717
Cytoplasm, perinuclear region	ECO:0000250
Midbody	ECO:0000269	PubMed:17726514
Myelin membrane	ECO:0000250
Nucleus	ECO:0000269	PubMed:12697818
Nucleus	ECO:0000269	PubMed:16079181
Nucleus	ECO:0000269	PubMed:16648462
Nucleus	ECO:0000269	PubMed:17726514
Nucleus	ECO:0000269	PubMed:20543840
Nucleus	ECO:0000269	PubMed:23908241
Nucleus	ECO:0000269	PubMed:24177535
Perikaryon	ECO:0000250

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Approved
breast	myoepithelial cells	Medium	Approved
cerebral cortex	neuronal cells	Medium	Approved
cerebral cortex	neuropil	Medium	Approved
duodenum	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Low	Approved
kidney	cells in tubules	Low	Approved
lung	macrophages	Medium	Approved
rectum	glandular cells	Medium	Approved
skeletal muscle	myocytes	Medium	Approved
small intestine	glandular cells	Medium	Approved
smooth muscle	smooth muscle cells	High	Approved
testis	spermatogonia cells	High	Approved

Summary of Q8IXJ6

Gene: SIRT2, SIR2L, SIR2L2
Protein: NAD-dependent protein deacetylase sirtuin-2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q8IXJ6

Gene: SIRT2, SIR2L, SIR2L2 Protein: NAD-dependent protein deacetylase sirtuin-2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: SIRT2, SIR2L, SIR2L2
Protein: NAD-dependent protein deacetylase sirtuin-2