Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.3.-
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
3.6.1.-
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
3.6.1.68
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
geranyl diphosphate phosphohydrolase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0045339 | farnesyl diphosphate catabolic process |
| Biological Process | GO:0033383 | geranyl diphosphate metabolic process |
| Biological Process | GO:1902247 | geranylgeranyl diphosphate catabolic process |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0006720 | isoprenoid metabolic process |
| Biological Process | GO:0046839 | phospholipid dephosphorylation |
| Biological Process | GO:1902565 | positive regulation of neutrophil activation |
| Biological Process | GO:0018342 | protein prenylation |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0106405 | isoprenoid diphosphate phosphatase activity |
| Molecular Function | GO:0042577 | lipid phosphatase activity |
| Molecular Function | GO:0016829 | lyase activity |
| Molecular Function | GO:0052642 | lysophosphatidic acid phosphatase activity |
| Molecular Function | GO:0008195 | phosphatidate phosphatase activity |
| Molecular Function | GO:0042392 | sphingosine-1-phosphate phosphatase activity |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005637 | nuclear inner membrane |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-191273 | Cholesterol biosynthesis | Internal node | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Endoplasmic reticulum membrane | ECO:0000269 | PubMed:16464866 |
| Endoplasmic reticulum membrane | ECO:0000269 | PubMed:18930839 |
| Endoplasmic reticulum membrane | ECO:0000269 | PubMed:20110354 |
| Nucleus envelope | ECO:0000269 | PubMed:18930839 |
| Nucleus inner membrane | ECO:0000305 | PubMed:20110354 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Low | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Medium | Approved |
| fallopian tube | glandular cells | Low | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Low | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | hepatocytes | Low | Approved |
| lung | macrophages | Low | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | Low | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Low | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | keratinocytes | Low | Approved |
| skin 1 | melanocytes | Low | Approved |
| small intestine | glandular cells | Medium | Approved |
| soft tissue 1 | chondrocytes | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| spleen | cells in red pulp | Low | Approved |
| spleen | cells in white pulp | Medium | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | preleptotene spermatocytes | High | Approved |
| testis | sertoli cells | Low | Approved |
| testis | spermatogonia cells | High | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|