MultifacetedProtDB - Bologna Biocomputing Group

Summary of Q8IY26

Gene: PLPP6, PDP1, PPAPDC2
Protein: Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

Protein family
Protein sequence
Protein function

Catalytic activity

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EC number	EC number description
3.1.3.-	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases;
3.6.1.-	Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides;
3.6.1.68	Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides; geranyl diphosphate phosphohydrolase

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Publications

Structure

GO term

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GO ontology	GO term	GO description
Biological Process	GO:0006695	cholesterol biosynthetic process
Biological Process	GO:0045339	farnesyl diphosphate catabolic process
Biological Process	GO:0033383	geranyl diphosphate metabolic process
Biological Process	GO:1902247	geranylgeranyl diphosphate catabolic process
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0006720	isoprenoid metabolic process
Biological Process	GO:0046839	phospholipid dephosphorylation
Biological Process	GO:1902565	positive regulation of neutrophil activation
Biological Process	GO:0018342	protein prenylation
Cellular Component	GO:0005789	endoplasmic reticulum membrane

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InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

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Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Medium	Approved
breast	glandular cells	Medium	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	Medium	Approved
cerebral cortex	endothelial cells	Low	Approved
cerebral cortex	neuronal cells	Medium	Approved
cervix	glandular cells	Low	Approved

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Disease