MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
5IJN	21.4	Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205)
5IJO	21.4	Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205)
7MW0	2.0	Crystal structure of Homo sapiens NUP93 solenoid (residues 174-819)
7MW1	3.4	Crystal structure of the Homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53 residues 84-150)
7PER	35.0	Model of the inner ring of the human nuclear pore complex
7R5J	50.0	Human nuclear pore complex (dilated)
7R5K	12.0	Human nuclear pore complex (constricted)

GO term

GO ontology	GO term	GO description
Biological Process	GO:0060395	SMAD protein signal transduction
Biological Process	GO:0006998	nuclear envelope organization
Biological Process	GO:0051292	nuclear pore complex assembly
Biological Process	GO:0006913	nucleocytoplasmic transport
Biological Process	GO:0016973	poly(A)+ mRNA export from nucleus
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction
Biological Process	GO:0006606	protein import into nucleus
Molecular Function	GO:0017056	structural constituent of nuclear pore
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0034399	nuclear periphery
Cellular Component	GO:0005643	nuclear pore

InterPro / Pfam

InterPro	InterPro name
IPR007231	Nucleoporin interacting component Nup93/Nic96

Pfam	Pfam name
PF04097	Nup93/Nic96

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1169408	ISG15 antiviral mechanism	Leaf	R-HSA-168256	Immune System
R-HSA-159227	Transport of the SLBP independent Mature mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	Leaf	R-HSA-1643685	Disease
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	Leaf	R-HSA-1643685	Disease
R-HSA-168276	NS1 Mediated Effects on Host Pathways	Internal node	R-HSA-1643685	Disease
R-HSA-168325	Viral Messenger RNA Synthesis	Leaf	R-HSA-1643685	Disease
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	Leaf	R-HSA-1643685	Disease
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	Leaf	R-HSA-1430728	Metabolism
R-HSA-180746	Nuclear import of Rev protein	Leaf	R-HSA-1643685	Disease
R-HSA-180910	Vpr-mediated nuclear import of PICs	Leaf	R-HSA-1643685	Disease
R-HSA-191859	snRNP Assembly	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3232142	SUMOylation of ubiquitinylation proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-4085377	SUMOylation of SUMOylation proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4551638	SUMOylation of chromatin organization proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4570464	SUMOylation of RNA binding proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4615885	SUMOylation of DNA replication proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5578749	Transcriptional regulation by small RNAs	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	Leaf	R-HSA-1643685	Disease
R-HSA-6784531	tRNA processing in the nucleus	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-9609690	HCMV Early Events	Leaf	R-HSA-1643685	Disease
R-HSA-9610379	HCMV Late Events	Leaf	R-HSA-1643685	Disease
R-HSA-9615933	Postmitotic nuclear pore complex (NPC) reformation	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Nucleus envelope	ECO:0000269	PubMed:26878725
Nucleus envelope	ECO:0000269	PubMed:9348540
Nucleus membrane	ECO:0000250
Nucleus, nuclear pore complex	ECO:0000269	PubMed:12802065
Nucleus, nuclear pore complex	ECO:0000269	PubMed:15229283
Nucleus, nuclear pore complex	ECO:0000269	PubMed:9348540

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000093	Proteinuria
HP:0000097	Focal segmental glomerulosclerosis
HP:0000707	Abnormality of the nervous system
HP:0000737	Irritability
HP:0000790	Hematuria
HP:0000969	Edema
HP:0001945	Fever
HP:0001967	Diffuse mesangial sclerosis
HP:0002027	Abdominal pain
HP:0002315	Headache
HP:0002586	Peritonitis
HP:0003073	Hypoalbuminemia
HP:0003676	Progressive
HP:0003774	Stage 5 chronic kidney disease
HP:0011947	Respiratory tract infection
HP:0012579	Minimal change glomerulonephritis
HP:0012588	Steroid-resistant nephrotic syndrome
HP:0012622	Chronic kidney disease
HP:0031504	Foamy urine
HP:0100539	Periorbital edema

Tissue and cell type

Disease

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
focal segmental glomerulosclerosis	MONDO:0005363	N26	chapter14, Diseases of the genitourinary system	OMIMPS:603278
nephrotic syndrome, type 12	MONDO:0014817	N04	chapter14, Diseases of the genitourinary system	OMIM:616892

Summary of Q8N1F7

Gene: NUP93, KIAA0095
Protein: Nuclear pore complex protein Nup93

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q8N1F7

Gene: NUP93, KIAA0095 Protein: Nuclear pore complex protein Nup93

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: NUP93, KIAA0095
Protein: Nuclear pore complex protein Nup93