Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
1.1.1.100
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
3-oxoacyl-[acyl-carrier-protein] reductase
1.6.5.10
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor;
NADPH dehydrogenase (quinone)
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0044597 | daunorubicin metabolic process |
| Biological Process | GO:0044598 | doxorubicin metabolic process |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0051290 | protein heterotetramerization |
| Biological Process | GO:0051289 | protein homotetramerization |
| Molecular Function | GO:0004316 | 3-oxoacyl-acyl-carrier-protein reductase (NADPH) activity |
| Molecular Function | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity |
| Molecular Function | GO:0070402 | NADPH binding |
| Molecular Function | GO:0008753 | NADPH dehydrogenase (quinone) activity |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Molecular Function | GO:0048038 | quinone binding |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:1990204 | oxidoreductase complex |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | Internal node | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Mitochondrion matrix | ECO:0000269 | PubMed:19000905 |
| Mitochondrion matrix | ECO:0000269 | PubMed:19571038 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | High | Supported |
| appendix | glandular cells | High | Supported |
| bone marrow | hematopoietic cells | Low | Supported |
| breast | glandular cells | High | Supported |
| breast | myoepithelial cells | Medium | Supported |
| bronchus | respiratory epithelial cells | Medium | Supported |
| caudate | glial cells | Low | Supported |
| caudate | neuronal cells | Low | Supported |
| cerebellum | Purkinje cells | Medium | Supported |
| cerebellum | cells in granular layer | Medium | Supported |
| cerebellum | cells in molecular layer | Low | Supported |
| cerebral cortex | neuronal cells | Low | Supported |
| cerebral cortex | neuropil | Medium | Supported |
| cervix | glandular cells | Low | Supported |
| cervix | squamous epithelial cells | Medium | Supported |
| colon | endothelial cells | Medium | Supported |
| colon | glandular cells | High | Supported |
| colon | peripheral nerve/ganglion | Medium | Supported |
| duodenum | glandular cells | Medium | Supported |
| endometrium 1 | cells in endometrial stroma | Low | Supported |
| endometrium 1 | glandular cells | Medium | Supported |
| endometrium 2 | glandular cells | Medium | Supported |
| epididymis | glandular cells | Medium | Supported |
| esophagus | squamous epithelial cells | Medium | Supported |
| fallopian tube | glandular cells | Medium | Supported |
| gallbladder | glandular cells | High | Supported |
| heart muscle | cardiomyocytes | Medium | Supported |
| hippocampus | neuronal cells | Medium | Supported |
| kidney | cells in glomeruli | Low | Supported |
| kidney | cells in tubules | High | Supported |
| liver | cholangiocytes | Low | Supported |
| liver | hepatocytes | High | Supported |
| lung | alveolar cells type II | Low | Supported |
| lung | endothelial cells | Low | Supported |
| lung | macrophages | Low | Supported |
| lymph node | non-germinal center cells | Medium | Supported |
| nasopharynx | respiratory epithelial cells | High | Supported |
| pancreas | exocrine glandular cells | High | Supported |
| pancreas | pancreatic endocrine cells | High | Supported |
| parathyroid gland | glandular cells | High | Supported |
| placenta | trophoblastic cells | Medium | Supported |
| prostate | glandular cells | Medium | Supported |
| rectum | glandular cells | High | Supported |
| salivary gland | glandular cells | Medium | Supported |
| seminal vesicle | glandular cells | Medium | Supported |
| skin 1 | Langerhans | Low | Supported |
| skin 1 | fibroblasts | Medium | Supported |
| skin 1 | keratinocytes | Medium | Supported |
| skin 1 | melanocytes | Medium | Supported |
| skin 2 | epidermal cells | Medium | Supported |
| small intestine | glandular cells | High | Supported |
| smooth muscle | smooth muscle cells | Low | Supported |
| soft tissue 1 | fibroblasts | Medium | Supported |
| soft tissue 2 | fibroblasts | Medium | Supported |
| spleen | cells in white pulp | Low | Supported |
| stomach 1 | glandular cells | High | Supported |
| stomach 2 | glandular cells | Medium | Supported |
| testis | Leydig cells | High | Supported |
| testis | elongated or late spermatids | Medium | Supported |
| testis | pachytene spermatocytes | Low | Supported |
| testis | preleptotene spermatocytes | Low | Supported |
| testis | round or early spermatids | Medium | Supported |
| testis | spermatogonia cells | Medium | Supported |
| thyroid gland | glandular cells | High | Supported |
| tonsil | germinal center cells | Low | Supported |
| tonsil | non-germinal center cells | Medium | Supported |
| tonsil | squamous epithelial cells | Low | Supported |
| urinary bladder | urothelial cells | Medium | Supported |
| vagina | squamous epithelial cells | Medium | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|