MultifacetedProtDB - Bologna Biocomputing Group

Summary of Q8N5Z0

Gene: AADAT, KAT2, KYAT2
Protein: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Protein family
Protein sequence
Protein function

Catalytic activity

EC number	EC number description
2.6.1.39	Transferases; Transferring nitrogenous groups; Transaminases; 2-aminoadipate transaminase
2.6.1.4	Transferases; Transferring nitrogenous groups; Transaminases; glycine transaminase
2.6.1.63	Transferases; Transferring nitrogenous groups; Transaminases; kynurenine—glyoxylate transaminase
2.6.1.7	Transferases; Transferring nitrogenous groups; Transaminases; kynurenine—oxoglutarate transaminase
2.6.1.73	Transferases; Transferring nitrogenous groups; Transaminases; methionine—glyoxylate transaminase

Publications

Structure

Link to AlphaFold model

PDB	Resolution (Å)	PDB name
2QLR	2.3	Crystal structure of human kynurenine aminotransferase II
2R2N	1.95	The crystal structure of human kynurenine aminotransferase II in complex with kynurenine
2VGZ	2.3	CRYSTAL STRUCTURE OF HUMAN KYNURENINE AMINOTRANSFERASE II
2XH1	2.1	Crystal structure of human KAT II-inhibitor complex
3DC1	2.5	Crystal structure of kynurenine aminotransferase II complex with alpha-ketoglutarate
3UE8	3.22	Kynurenine Aminotransferase II Inhibitors
4GDY	2.89	Kynurenine Aminotransferase II inhibitors
4GE4	2.41	Kynurenine Aminotransferase II Inhibitors
4GE7	2.1	Kynurenine Aminotransferase II Inhibitors
4GE9	2.43	Kynurenine Aminotransferase II Inhibitors
4GEB	2.15	Kynurenine Aminotransferase II Inhibitors
5EFS	1.82503	The crystal structure of human kynurenine aminotransferase II
5EUN	1.825	The Crystal Structure of Human Kynurenine Aminotransferase II, PLP-bound form, at 1.83 A
5TF5	1.807	CRYSTAL STRUCTURE OF HUMAN KAT-2 IN COMPLEX WITH A REVERSIBLE INHIBITOR
6D0A	1.46809	Crystal structure of Kynurenine Aminotransferase-II in apo-form, at 1.47 A resolution
6T8P	2.02	HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide
6T8Q	2.51	HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006103	2-oxoglutarate metabolic process
Biological Process	GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine
Biological Process	GO:1901605	alpha-amino acid metabolic process
Biological Process	GO:0009058	biosynthetic process
Biological Process	GO:0006536	glutamate metabolic process
Biological Process	GO:0070189	kynurenine metabolic process
Molecular Function	GO:0047536	2-aminoadipate transaminase activity
Molecular Function	GO:0047958	glycine:2-oxoglutarate aminotransferase activity
Molecular Function	GO:0047315	kynurenine-glyoxylate transaminase activity
Molecular Function	GO:0016212	kynurenine-oxoglutarate transaminase activity
Molecular Function	GO:0050094	methionine-glyoxylate transaminase activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0030170	pyridoxal phosphate binding
Cellular Component	GO:0005759	mitochondrial matrix

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
appendix	glandular cells	Low	Enhanced
colon	glandular cells	Low	Enhanced
duodenum	glandular cells	Low	Enhanced
kidney	distal tubules	Low	Enhanced
kidney	proximal tubules (cell body)	Medium	Enhanced
liver	hepatocytes	Medium	Enhanced
small intestine	glandular cells	Low	Enhanced
stomach 1	glandular cells	Low	Enhanced
testis	Leydig cells	Low	Enhanced

Disease