MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.3.1.-	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups;
2.3.1.286	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; protein acetyllysine N-acetyltransferase
2.4.2.-	Transferases; Glycosyltransferases; Pentosyltransferases;

Structure

PDB	Resolution (Å)	PDB name
3K35	2.0	Crystal Structure of Human SIRT6
3PKI	2.04	Human SIRT6 crystal structure in complex with ADP ribose
3PKJ	2.12	Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose
3ZG6	2.2	The novel de-long chain fatty acid function of human sirt6
5MF6	1.87	Human Sirt6 in complex with activator UBCS039
5MFP	1.98	Human Sirt6 in complex with activator UBCS58
5MFZ	2.1	Human Sirt6 in complex with small molecule UBCS40
5MGN	2.07	Human Sirt6 in complex with activator UBCS38
5X16	1.97	Sirt6 apo structure
5Y2F	2.53	Human SIRT6 in complex with allosteric activator MDL-801
6HOY	1.7	Human Sirt6 in complex with ADP-ribose and the inhibitor trichostatin A
6QCD	1.84	Human Sirt6 in complex with ADP-ribose and the activator quercetin
6QCE	1.9	Human Sirt6 in complex with ADP-ribose and the activator isoquercetin
6QCH	2.1	Human Sirt6 in complex with ADP-ribose and the activator cyanidin
6QCJ	2.01	Human Sirt6 in complex with ADP-ribose and the inhibitor catechin gallate
6XUY	2.13	Human Sirt6 13-308 in complex with ADP-ribose
6XV1	1.95	Human Sirt6 13-308 in complex with ADP-ribose and the activator MDL-801
6XV6	1.75	Human Sirt6 3-318 in complex with ADP-ribose
6XVG	2.1	Human Sirt6 3-318 in complex with ADP-ribose and the activator MDL-801
6ZU4	2.46	Human Sirt6 13-308 in complex with ADP-ribose and the activator fluvastatin
7CL0	2.53	Crystal structure of human SIRT6
7CL1	3.2	Human SIRT6 in complex with allosteric activator MDL-801 (3.2A)

GO term

GO ontology	GO term	GO description
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling
Biological Process	GO:0006284	base-excision repair
Biological Process	GO:0055007	cardiac muscle cell differentiation
Biological Process	GO:0032922	circadian regulation of gene expression
Biological Process	GO:0008340	determination of adult lifespan
Biological Process	GO:0006302	double-strand break repair
Biological Process	GO:0042593	glucose homeostasis
Biological Process	GO:0016575	histone deacetylation
Biological Process	GO:0042181	ketone biosynthetic process
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:2000773	negative regulation of cellular senescence
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic
Biological Process	GO:0045721	negative regulation of gluconeogenesis
Biological Process	GO:0046325	negative regulation of glucose import
Biological Process	GO:0045820	negative regulation of glycolytic process
Biological Process	GO:0042308	negative regulation of protein import into nucleus
Biological Process	GO:0120186	negative regulation of protein localization to chromatin
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II
Biological Process	GO:0031508	pericentric heterochromatin formation
Biological Process	GO:1905555	positive regulation of blood vessel branching
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis
Biological Process	GO:2000781	positive regulation of double-strand break repair
Biological Process	GO:0045600	positive regulation of fat cell differentiation
Biological Process	GO:0048146	positive regulation of fibroblast proliferation
Biological Process	GO:1901727	positive regulation of histone deacetylase activity
Biological Process	GO:0032024	positive regulation of insulin secretion
Biological Process	GO:0046827	positive regulation of protein export from nucleus
Biological Process	GO:0120187	positive regulation of protein localization to chromatin
Biological Process	GO:2000738	positive regulation of stem cell differentiation
Biological Process	GO:1902459	positive regulation of stem cell population maintenance
Biological Process	GO:2000648	positive regulation of stem cell proliferation
Biological Process	GO:0032206	positive regulation of telomere maintenance
Biological Process	GO:1901485	positive regulation of transcription factor catabolic process
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation
Biological Process	GO:0006476	protein deacetylation
Biological Process	GO:0051697	protein delipidation
Biological Process	GO:0031648	protein destabilization
Biological Process	GO:1990166	protein localization to site of double-strand break
Biological Process	GO:0042752	regulation of circadian rhythm
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination
Biological Process	GO:0050994	regulation of lipid catabolic process
Biological Process	GO:0019216	regulation of lipid metabolic process
Biological Process	GO:1903076	regulation of protein localization to plasma membrane
Biological Process	GO:0050708	regulation of protein secretion
Biological Process	GO:0009411	response to UV
Biological Process	GO:0010526	retrotransposon silencing
Biological Process	GO:0031509	subtelomeric heterochromatin formation
Molecular Function	GO:0140612	DNA damage sensor activity
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity
Molecular Function	GO:0070403	NAD+ binding
Molecular Function	GO:0140804	NAD+- protein-lysine ADP-ribosyltransferase activity
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity
Molecular Function	GO:0106274	NAD+-protein-arginine ADP-ribosyltransferase activity
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity
Molecular Function	GO:0140774	NAD-dependent protein depalmitoylase activity
Molecular Function	GO:1904841	TORC2 complex binding
Molecular Function	GO:0031490	chromatin DNA binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003684	damaged DNA binding
Molecular Function	GO:0008047	enzyme activator activity
Molecular Function	GO:0035033	histone deacetylase regulator activity
Molecular Function	GO:0106222	lncRNA binding
Molecular Function	GO:0140677	molecular function activator activity
Molecular Function	GO:0031491	nucleosome binding
Molecular Function	GO:0016779	nucleotidyltransferase activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0003714	transcription corepressor activity
Molecular Function	GO:0140416	transcription regulator inhibitor activity
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0099115	chromosome, subtelomeric region
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0043231	intracellular membrane-bounded organelle
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005721	pericentric heterochromatin
Cellular Component	GO:0090734	site of DNA damage
Cellular Component	GO:0035861	site of double-strand break

InterPro / Pfam

InterPro	InterPro name
IPR003000	Sirtuin family
IPR026590	Sirtuin family, catalytic core domain
IPR029035	DHS-like NAD/FAD-binding domain superfamily

Pfam	Pfam name
PF02146	Sir2 family

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1912408	Pre-NOTCH Transcription and Translation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5693607	Processing of DNA double-strand break ends	Leaf	R-HSA-73894	DNA Repair

Subcellular location

Location	ECO term	Pubmed
Chromosome	ECO:0000269	PubMed:21680843
Chromosome	ECO:0000269	PubMed:23911928
Chromosome	ECO:0000269	PubMed:26456828
Chromosome	ECO:0000269	PubMed:27043296
Chromosome	ECO:0000269	PubMed:27568560
Chromosome	ECO:0000269	PubMed:27912097
Chromosome	ECO:0000269	PubMed:31995034
Chromosome	ECO:0000269	PubMed:32538779
Chromosome	ECO:0000269	PubMed:32789493
Chromosome, telomere	ECO:0000269	PubMed:18337721
Endoplasmic reticulum	ECO:0000269	PubMed:23552949
Nucleus	ECO:0000269	PubMed:16079181
Nucleus	ECO:0000269	PubMed:18337721
Nucleus	ECO:0000269	PubMed:19135889
Nucleus	ECO:0000269	PubMed:26456828
Nucleus	ECO:0000269	PubMed:26898756
Nucleus	ECO:0000269	PubMed:29555651

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Supported
adrenal gland	glandular cells	High	Supported
appendix	glandular cells	High	Supported
appendix	lymphoid tissue	High	Supported
bone marrow	hematopoietic cells	High	Supported
breast	adipocytes	Medium	Supported
breast	glandular cells	Medium	Supported
breast	myoepithelial cells	Medium	Supported
bronchus	respiratory epithelial cells	High	Supported
caudate	glial cells	Low	Supported
caudate	neuronal cells	High	Supported
cerebellum	Purkinje cells	High	Supported
cerebellum	cells in granular layer	High	Supported
cerebellum	cells in molecular layer	High	Supported
cerebral cortex	endothelial cells	Medium	Supported
cerebral cortex	glial cells	Medium	Supported
cerebral cortex	neuronal cells	High	Supported
cervix	glandular cells	High	Supported
cervix	squamous epithelial cells	High	Supported
colon	endothelial cells	Medium	Supported
colon	glandular cells	High	Supported
duodenum	glandular cells	High	Supported
endometrium 1	cells in endometrial stroma	High	Supported
endometrium 1	glandular cells	High	Supported
endometrium 2	cells in endometrial stroma	High	Supported
endometrium 2	glandular cells	High	Supported
epididymis	glandular cells	High	Supported
esophagus	squamous epithelial cells	High	Supported
fallopian tube	glandular cells	High	Supported
gallbladder	glandular cells	High	Supported
heart muscle	cardiomyocytes	High	Supported
hippocampus	glial cells	Low	Supported
hippocampus	neuronal cells	Medium	Supported
kidney	cells in glomeruli	High	Supported
kidney	cells in tubules	High	Supported
liver	cholangiocytes	Medium	Supported
liver	hepatocytes	High	Supported
lung	alveolar cells type I	High	Supported
lung	alveolar cells type II	High	Supported
lung	endothelial cells	High	Supported
lung	macrophages	High	Supported
lymph node	germinal center cells	High	Supported
lymph node	non-germinal center cells	High	Supported
nasopharynx	respiratory epithelial cells	High	Supported
oral mucosa	squamous epithelial cells	High	Supported
ovary	follicle cells	Medium	Supported
ovary	ovarian stroma cells	Medium	Supported
pancreas	exocrine glandular cells	High	Supported
pancreas	pancreatic endocrine cells	High	Supported
parathyroid gland	glandular cells	Medium	Supported
placenta	decidual cells	High	Supported
placenta	trophoblastic cells	Medium	Supported
prostate	glandular cells	Medium	Supported
rectum	glandular cells	High	Supported
salivary gland	glandular cells	High	Supported
seminal vesicle	glandular cells	High	Supported
skeletal muscle	myocytes	High	Supported
skin 1	Langerhans	Medium	Supported
skin 1	fibroblasts	Medium	Supported
skin 1	keratinocytes	Medium	Supported
skin 1	melanocytes	Medium	Supported
skin 2	epidermal cells	High	Supported
small intestine	glandular cells	High	Supported
smooth muscle	smooth muscle cells	High	Supported
soft tissue 1	chondrocytes	Medium	Supported
soft tissue 1	fibroblasts	High	Supported
soft tissue 1	peripheral nerve	High	Supported
soft tissue 2	fibroblasts	High	Supported
soft tissue 2	peripheral nerve	Medium	Supported
spleen	cells in red pulp	High	Supported
spleen	cells in white pulp	High	Supported
stomach 1	glandular cells	High	Supported
stomach 2	glandular cells	High	Supported
testis	Leydig cells	High	Supported
testis	pachytene spermatocytes	Medium	Supported
testis	peritubular cells	High	Supported
testis	preleptotene spermatocytes	Medium	Supported
testis	round or early spermatids	Medium	Supported
testis	sertoli cells	High	Supported
testis	spermatogonia cells	High	Supported
thyroid gland	glandular cells	High	Supported
tonsil	germinal center cells	High	Supported
tonsil	non-germinal center cells	High	Supported
tonsil	squamous epithelial cells	High	Supported
urinary bladder	urothelial cells	High	Supported
vagina	squamous epithelial cells	High	Supported

Summary of Q8N6T7

Gene: SIRT6, SIR2L6
Protein: NAD-dependent protein deacylase sirtuin-6

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q8N6T7

Gene: SIRT6, SIR2L6 Protein: NAD-dependent protein deacylase sirtuin-6

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: SIRT6, SIR2L6
Protein: NAD-dependent protein deacylase sirtuin-6