Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0008637 | apoptotic mitochondrial changes |
| Biological Process | GO:0000422 | autophagy of mitochondrion |
| Biological Process | GO:0007049 | cell cycle |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0051882 | mitochondrial depolarization |
| Biological Process | GO:0030889 | negative regulation of B cell proliferation |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0033088 | negative regulation of immature T cell proliferation in thymus |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:2000435 | negative regulation of protein neddylation |
| Biological Process | GO:1903051 | negative regulation of proteolysis involved in protein catabolic process |
| Biological Process | GO:1904667 | negative regulation of ubiquitin protein ligase activity |
| Biological Process | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0051444 | negative regulation of ubiquitin-protein transferase activity |
| Biological Process | GO:0030575 | nuclear body organization |
| Biological Process | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
| Biological Process | GO:0033235 | positive regulation of protein sumoylation |
| Biological Process | GO:1901798 | positive regulation of signal transduction by p53 class mediator |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0070534 | protein K63-linked ubiquitination |
| Biological Process | GO:0031648 | protein destabilization |
| Biological Process | GO:1902570 | protein localization to nucleolus |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0000209 | protein polyubiquitination |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0016925 | protein sumoylation |
| Biological Process | GO:0006364 | rRNA processing |
| Biological Process | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| Biological Process | GO:1902510 | regulation of apoptotic DNA fragmentation |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0046825 | regulation of protein export from nucleus |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:1903214 | regulation of protein targeting to mitochondrion |
| Biological Process | GO:1904666 | regulation of ubiquitin protein ligase activity |
| Biological Process | GO:0048103 | somatic stem cell division |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0097371 | MDM2/MDM4 family protein binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0019789 | SUMO transferase activity |
| Molecular Function | GO:0097718 | disordered domain specific binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:1990948 | ubiquitin ligase inhibitor activity |
| Molecular Function | GO:0055105 | ubiquitin-protein transferase inhibitor activity |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-111471 | Apoptotic factor-mediated response | Internal node | R-HSA-5357801 | Programmed Cell Death |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-2559585 | Oncogene Induced Senescence | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-3232118 | SUMOylation of transcription factors | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-6804757 | Regulation of TP53 Degradation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-69541 | Stabilization of p53 | Internal node | R-HSA-1640170 | Cell Cycle |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-9645722 | Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9646303 | Evasion of Oncogene Induced Senescence Due to p14ARF Defects | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9646304 | Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Internal node | R-HSA-8953897 | Cellular responses to stimuli |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Mitochondrion | ECO:0000269 | PubMed:16713577 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:16173922 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:18305112 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:22094112 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:27323397 |
| Nucleus, nucleoplasm | ECO:0000269 | PubMed:18305112 |
| Nucleus, nucleoplasm | ECO:0000269 | PubMed:27323397 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000080 | Abnormality of reproductive system physiology |
| HP:0000488 | Retinopathy |
| HP:0000737 | Irritability |
| HP:0000739 | Anxiety |
| HP:0000819 | Diabetes mellitus |
| HP:0000822 | Hypertension |
| HP:0000859 | Hyperaldosteronism |
| HP:0000952 | Jaundice |
| HP:0000958 | Dry skin |
| HP:0000975 | Hyperhidrosis |
| HP:0000998 | Hypertrichosis |
| HP:0001065 | Striae distensae |
| HP:0001324 | Muscle weakness |
| HP:0001433 | Hepatosplenomegaly |
| HP:0001480 | Freckling |
| HP:0001595 | Abnormal hair morphology |
| HP:0001738 | Exocrine pancreatic insufficiency |
| HP:0001824 | Weight loss |
| HP:0001909 | Leukemia |
| HP:0001939 | Abnormality of metabolism/homeostasis |
| HP:0001962 | Palpitations |
| HP:0002017 | Nausea and vomiting |
| HP:0002027 | Abdominal pain |
| HP:0002039 | Anorexia |
| HP:0002071 | Abnormality of extrapyramidal motor function |
| HP:0002254 | Intermittent diarrhea |
| HP:0002664 | Neoplasm |
| HP:0002665 | Lymphoma |
| HP:0002669 | Osteosarcoma |
| HP:0002716 | Lymphadenopathy |
| HP:0002859 | Rhabdomyosarcoma |
| HP:0002860 | Squamous cell carcinoma |
| HP:0002861 | Melanoma |
| HP:0002863 | Myelodysplasia |
| HP:0002885 | Medulloblastoma |
| HP:0002888 | Ependymoma |
| HP:0002890 | Thyroid carcinoma |
| HP:0002894 | Neoplasm of the pancreas |
| HP:0002896 | Neoplasm of the liver |
| HP:0002900 | Hypokalemia |
| HP:0002910 | Elevated hepatic transaminase |
| HP:0003002 | Breast carcinoma |
| HP:0003003 | Colon cancer |
| HP:0003110 | Abnormality of urine homeostasis |
| HP:0003118 | Increased circulating cortisol level |
| HP:0003418 | Back pain |
| HP:0003466 | Paradoxical increased cortisol secretion on dexamethasone suppression test |
| HP:0003764 | Nevus |
| HP:0004324 | Increased body weight |
| HP:0004389 | Intestinal pseudo-obstruction |
| HP:0004396 | Poor appetite |
| HP:0004808 | Acute myeloid leukemia |
| HP:0005249 | Functional intestinal obstruction |
| HP:0006721 | Acute lymphoblastic leukemia |
| HP:0006725 | Pancreatic adenocarcinoma |
| HP:0006744 | Adrenocortical carcinoma |
| HP:0006753 | Neoplasm of the stomach |
| HP:0007378 | Neoplasm of the gastrointestinal tract |
| HP:0009592 | Astrocytoma |
| HP:0009726 | Renal neoplasm |
| HP:0010788 | Testicular neoplasm |
| HP:0011748 | Adrenocorticotropic hormone deficiency |
| HP:0012030 | Increased urinary cortisol level |
| HP:0012056 | Cutaneous melanoma |
| HP:0012125 | Prostate cancer |
| HP:0012126 | Stomach cancer |
| HP:0012142 | Pancreatic squamous cell carcinoma |
| HP:0012174 | Glioblastoma multiforme |
| HP:0012182 | Oropharyngeal squamous cell carcinoma |
| HP:0012189 | Hodgkin lymphoma |
| HP:0012288 | Neoplasm of head and neck |
| HP:0012334 | Extrahepatic cholestasis |
| HP:0012432 | Chronic fatigue |
| HP:0012539 | Non-Hodgkin lymphoma |
| HP:0025134 | Increased serum estradiol |
| HP:0025269 | Panic attack |
| HP:0025318 | Ovarian carcinoma |
| HP:0025380 | Increased circulating androstenedione concentration |
| HP:0025436 | Elevated serum 11-deoxycortisol |
| HP:0030070 | Central primitive neuroectodermal tumor |
| HP:0030078 | Lung adenocarcinoma |
| HP:0030348 | Increased circulating androgen concentration |
| HP:0030392 | Choroid plexus carcinoma |
| HP:0100006 | Neoplasm of the central nervous system |
| HP:0100013 | Neoplasm of the breast |
| HP:0100242 | Sarcoma |
| HP:0100526 | Neoplasm of the lung |
| HP:0100592 | Peritoneal abscess |
| HP:0100605 | Neoplasm of the larynx |
| HP:0100615 | Ovarian neoplasm |
| HP:0100743 | Neoplasm of the rectum |
| HP:0100763 | Abnormality of the lymphatic system |
| HP:0100768 | Choriocarcinoma |
| HP:0200063 | Colorectal polyposis |
| HP:0500022 | Abnormal circulating dehydroepiandrosterone concentration |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | glandular cells | High | Enhanced |
| appendix | lymphoid tissue | Medium | Enhanced |
| bone marrow | hematopoietic cells | Low | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| breast | myoepithelial cells | Medium | Enhanced |
| bronchus | respiratory epithelial cells | Medium | Enhanced |
| caudate | glial cells | Medium | Enhanced |
| caudate | neuronal cells | Medium | Enhanced |
| cerebellum | Purkinje cells | Medium | Enhanced |
| cerebellum | cells in molecular layer | Medium | Enhanced |
| cerebral cortex | endothelial cells | Low | Enhanced |
| cerebral cortex | glial cells | Low | Enhanced |
| cerebral cortex | neuronal cells | Low | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| colon | endothelial cells | Low | Enhanced |
| colon | glandular cells | High | Enhanced |
| colon | peripheral nerve/ganglion | High | Enhanced |
| duodenum | glandular cells | Medium | Enhanced |
| endometrium 1 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | cells in endometrial stroma | Low | Enhanced |
| endometrium 2 | glandular cells | Medium | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| esophagus | squamous epithelial cells | Low | Enhanced |
| fallopian tube | glandular cells | Medium | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| heart muscle | cardiomyocytes | Low | Enhanced |
| hippocampus | glial cells | Low | Enhanced |
| hippocampus | neuronal cells | Medium | Enhanced |
| kidney | cells in glomeruli | Medium | Enhanced |
| kidney | cells in tubules | Medium | Enhanced |
| liver | cholangiocytes | Low | Enhanced |
| lung | alveolar cells | Low | Enhanced |
| lung | macrophages | Low | Enhanced |
| lymph node | germinal center cells | Medium | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| ovary | follicle cells | Low | Enhanced |
| ovary | ovarian stroma cells | Low | Enhanced |
| pancreas | exocrine glandular cells | Low | Enhanced |
| pancreas | pancreatic endocrine cells | Medium | Enhanced |
| parathyroid gland | glandular cells | Low | Enhanced |
| placenta | decidual cells | Medium | Enhanced |
| placenta | trophoblastic cells | Medium | Enhanced |
| prostate | glandular cells | Low | Enhanced |
| rectum | glandular cells | Medium | Enhanced |
| salivary gland | glandular cells | Low | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skin 1 | Langerhans | Medium | Enhanced |
| skin 1 | fibroblasts | Medium | Enhanced |
| skin 1 | keratinocytes | Low | Enhanced |
| skin 1 | melanocytes | Medium | Enhanced |
| skin 2 | epidermal cells | Medium | Enhanced |
| small intestine | glandular cells | Low | Enhanced |
| spleen | cells in red pulp | Medium | Enhanced |
| spleen | cells in white pulp | Medium | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | Leydig cells | Medium | Enhanced |
| testis | elongated or late spermatids | High | Enhanced |
| testis | pachytene spermatocytes | Low | Enhanced |
| testis | preleptotene spermatocytes | Medium | Enhanced |
| testis | round or early spermatids | Low | Enhanced |
| testis | sertoli cells | Medium | Enhanced |
| testis | spermatogonia cells | Medium | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | Medium | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|