MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.2.2	Hydrolases; Acting on ester bonds; Thioester hydrolases; palmitoyl-CoA hydrolase
3.1.2.3	Hydrolases; Acting on ester bonds; Thioester hydrolases; succinyl-CoA hydrolase

PDB	Resolution (Å)	PDB name
3K2I	2.4	Human Acyl-coenzyme A thioesterase 4

GO ontology	GO term	GO description
Biological Process	GO:0006637	acyl-CoA metabolic process
Biological Process	GO:0043649	dicarboxylic acid catabolic process
Biological Process	GO:0043648	dicarboxylic acid metabolic process
Biological Process	GO:0006633	fatty acid biosynthetic process
Biological Process	GO:0006631	fatty acid metabolic process
Biological Process	GO:0001676	long-chain fatty acid metabolic process
Biological Process	GO:0032788	saturated monocarboxylic acid metabolic process
Biological Process	GO:0046459	short-chain fatty acid metabolic process
Biological Process	GO:0006104	succinyl-CoA metabolic process
Biological Process	GO:0032789	unsaturated monocarboxylic acid metabolic process
Biological Process	GO:0000038	very long-chain fatty acid metabolic process
Molecular Function	GO:0047617	acyl-CoA hydrolase activity
Molecular Function	GO:0052689	carboxylic ester hydrolase activity
Molecular Function	GO:0044466	glutaryl-CoA hydrolase activity
Molecular Function	GO:0102991	myristoyl-CoA hydrolase activity
Molecular Function	GO:0016290	palmitoyl-CoA hydrolase activity
Molecular Function	GO:0004778	succinyl-CoA hydrolase activity
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005782	peroxisomal matrix
Cellular Component	GO:0005777	peroxisome

InterPro	InterPro name
IPR006862	Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR014940	BAAT/Acyl-CoA thioester hydrolase C-terminal
IPR016662	Acyl-CoA thioesterase, long chain
IPR029058	Alpha/Beta hydrolase fold
IPR042490	Acyl-CoA thioester hydrolase/BAAT, N-terminal

Pfam	Pfam name
PF04775	Acyl-CoA thioester hydrolase/BAAT N-terminal region
PF08840	BAAT / Acyl-CoA thioester hydrolase C terminal

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-390247	Beta-oxidation of very long chain fatty acids	Leaf	R-HSA-1430728	Metabolism
R-HSA-9033241	Peroxisomal protein import	Internal node	R-HSA-9609507	Protein localization

Location	ECO term	Pubmed
Peroxisome	ECO:0000269	PubMed:16940157

Tissue	Cell type	Expression level	Reliability
appendix	glandular cells	Medium	Enhanced
appendix	lymphoid tissue	Low	Enhanced
bronchus	respiratory epithelial cells	Medium	Enhanced
caudate	glial cells	High	Enhanced
caudate	neuronal cells	Low	Enhanced
cerebellum	Purkinje cells	High	Enhanced
cerebellum	cells in granular layer	Low	Enhanced
cerebellum	cells in molecular layer	Medium	Enhanced
cerebral cortex	endothelial cells	Low	Enhanced
cerebral cortex	glial cells	High	Enhanced
cerebral cortex	neuronal cells	High	Enhanced
cerebral cortex	neuropil	Medium	Enhanced
colon	glandular cells	Low	Enhanced
duodenum	glandular cells	Low	Enhanced
epididymis	glandular cells	Low	Enhanced
fallopian tube	glandular cells	Medium	Enhanced
gallbladder	glandular cells	High	Enhanced
hippocampus	glial cells	High	Enhanced
hippocampus	neuronal cells	Low	Enhanced
kidney	cells in tubules	Medium	Enhanced
liver	hepatocytes	High	Enhanced
lung	macrophages	High	Enhanced
lymph node	germinal center cells	Medium	Enhanced
nasopharynx	respiratory epithelial cells	Medium	Enhanced
pancreas	pancreatic endocrine cells	Medium	Enhanced
placenta	decidual cells	Low	Enhanced
prostate	glandular cells	Low	Enhanced
rectum	glandular cells	Low	Enhanced
seminal vesicle	glandular cells	High	Enhanced
small intestine	glandular cells	Low	Enhanced
spleen	cells in red pulp	Medium	Enhanced
stomach 1	glandular cells	Low	Enhanced
testis	Leydig cells	Low	Enhanced
testis	cells in seminiferous ducts	Low	Enhanced
tonsil	non-germinal center cells	Medium	Enhanced