Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
1.8.4.-
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor;
5.3.4.1
Isomerases;
Intramolecular oxidoreductases;
Transposing S-S bonds;
protein disulfide-isomerase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2DIZ | The solution structure of the third thioredoxin domain of human Thioredoxin domain-containing protein 5 | |
| 3UJ1 | 2.651 | Crystal structure of the third thioredoxin domain of human ERp46 |
| 3UVT | 2.0 | Crystal structure of the third catalytic domain of ERp46 |
| 3WGD | 2.5 | Crystal structure of ERp46 Trx1 |
| 3WGE | 0.95 | Crystal structure of ERp46 Trx2 |
| 3WGX | 0.92 | Crystal structure of ERp46 Trx2 in a complex with Prx4 C-term |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0006457 | protein folding |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
| Molecular Function | GO:0015035 | protein-disulfide reductase activity |
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-432720 | Lysosome Vesicle Biogenesis | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Endoplasmic reticulum lumen | ECO:0000250 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Enhanced |
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | enterocytes | Medium | Enhanced |
| appendix | germinal center cells | Medium | Enhanced |
| appendix | goblet cells | Low | Enhanced |
| appendix | non-germinal center cells | Medium | Enhanced |
| bone marrow | hematopoietic cells | Medium | Enhanced |
| breast | glandular cells | Low | Enhanced |
| bronchus | ciliated cells (cell body) | Low | Enhanced |
| cerebellum | Purkinje cells | Low | Enhanced |
| cerebral cortex | neuronal cells | Low | Enhanced |
| cervix | glandular cells | Low | Enhanced |
| colon | mucosal lymphoid cells | High | Enhanced |
| duodenum | enterocytes | Medium | Enhanced |
| duodenum | goblet cells | Medium | Enhanced |
| duodenum | paneth cells | High | Enhanced |
| endometrium 1 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 2 | glandular cells | High | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| esophagus | squamous epithelial cells | Low | Enhanced |
| fallopian tube | non-ciliated cells | Medium | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| kidney | cells in tubules | Medium | Enhanced |
| lung | alveolar cells type II | Medium | Enhanced |
| lymph node | germinal center cells | Medium | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| nasopharynx | ciliated cells (cell body) | Medium | Enhanced |
| ovary | ovarian stroma cells | Low | Enhanced |
| pancreas | exocrine glandular cells | High | Enhanced |
| placenta | trophoblastic cells | Medium | Enhanced |
| rectum | endothelial cells | Medium | Enhanced |
| rectum | enterocytes | Low | Enhanced |
| rectum | goblet cells | Medium | Enhanced |
| rectum | mucosal lymphoid cells | High | Enhanced |
| rectum | peripheral nerve/ganglion | Low | Enhanced |
| salivary gland | glandular cells | Medium | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skin 1 | endothelial cells | Low | Enhanced |
| skin 1 | fibrohistiocytic cells | Medium | Enhanced |
| skin 1 | melanocytes | Medium | Enhanced |
| skin 2 | endothelial cells | Low | Enhanced |
| skin 2 | fibrohistiocytic cells | Medium | Enhanced |
| small intestine | enterocytes | Medium | Enhanced |
| small intestine | goblet cells | High | Enhanced |
| soft tissue 1 | fibroblasts | Low | Enhanced |
| spleen | cells in red pulp | Medium | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | High | Enhanced |
| testis | Leydig cells | Medium | Enhanced |
| testis | sertoli cells | Medium | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | non-germinal center cells | High | Enhanced |
| tonsil | squamous epithelial cells | Low | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|