Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.3.1.-
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
3.1.1.32
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
phospholipase A1
3.1.1.4
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
phospholipase A2
3.1.1.5
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
lysophospholipase
PDB | Resolution (Å) | PDB name |
---|---|---|
4X90 | 1.84 | Crystal structure of Lysosomal Phospholipase A2 |
4X91 | 2.3 | Crystal structure of Lysosomal Phospholipase A2 in complex with Isopropyl dodec-11-enylfluorophosphonate (IDFP) |
4X92 | 3.0 | Crystal structure of Lysosomal Phospholipase A2-S165A |
4X93 | 2.6 | Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (tetragonal form) |
4X94 | 2.7 | Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (hexagonal form) |
4X95 | 3.08 | Crystal structure of fully glycosylated Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP) |
4X97 | 2.65 | Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP) |
6MTW | 1.999 | Lysosomal Phospholipase A2 in complex with Zinc |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006672 | ceramide metabolic process |
Biological Process | GO:0006651 | diacylglycerol biosynthetic process |
Biological Process | GO:0009062 | fatty acid catabolic process |
Biological Process | GO:0006650 | glycerophospholipid metabolic process |
Biological Process | GO:0034638 | phosphatidylcholine catabolic process |
Biological Process | GO:0046470 | phosphatidylcholine metabolic process |
Biological Process | GO:0046338 | phosphatidylethanolamine catabolic process |
Biological Process | GO:0046471 | phosphatidylglycerol metabolic process |
Biological Process | GO:0006658 | phosphatidylserine metabolic process |
Biological Process | GO:0006644 | phospholipid metabolic process |
Molecular Function | GO:0052740 | 1-acyl-2-lysophosphatidylserine acylhydrolase activity |
Molecular Function | GO:0008374 | O-acyltransferase activity |
Molecular Function | GO:0016411 | acylglycerol O-acyltransferase activity |
Molecular Function | GO:0047499 | calcium-independent phospholipase A2 activity |
Molecular Function | GO:0004622 | lysophospholipase activity |
Molecular Function | GO:0102545 | phosphatidyl phospholipase B activity |
Molecular Function | GO:0052739 | phosphatidylserine 1-acylhydrolase activity |
Molecular Function | GO:0008970 | phospholipase A1 activity |
Molecular Function | GO:0005543 | phospholipid binding |
Molecular Function | GO:0008270 | zinc ion binding |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005576 | extracellular region |
Cellular Component | GO:0005615 | extracellular space |
Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
Cellular Component | GO:0005764 | lysosome |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005654 | nucleoplasm |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-1483115 | Hydrolysis of LPC | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Lysosome | ECO:0000269 | PubMed:23958596 |
Membrane | ECO:0000269 | PubMed:25727495 |
Secreted | ECO:0000269 | PubMed:10092508 |
Secreted | ECO:0000269 | PubMed:20410020 |