MultifacetedProtDB - Bologna Biocomputing Group

Catalytic activity

EC number	EC number description
3.1.1.111	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; phosphatidylserine sn-1 acylhydrolase
3.1.1.118	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; phospholipid sn-1 acylhydrolase
3.1.1.32	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; phospholipase A1

Publications

GO ontology	GO term	GO description
Biological Process	GO:0006629	lipid metabolic process
Biological Process	GO:0090141	positive regulation of mitochondrial fission
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0008970	phospholipase A1 activity
Molecular Function	GO:0004620	phospholipase activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol

InterPro	InterPro name
IPR004177	DDHD domain

Pfam	Pfam name
PF02862	DDHD domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1483166	Synthesis of PA	Leaf	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:15623529

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0001258	Spastic paraplegia
HP:0001347	Hyperreflexia
HP:0001761	Pes cavus
HP:0002061	Lower limb spasticity
HP:0002063	Rigidity
HP:0002064	Spastic gait
HP:0002172	Postural instability
HP:0002317	Unsteady gait
HP:0002355	Difficulty walking
HP:0002650	Scoliosis
HP:0002936	Distal sensory impairment
HP:0003477	Peripheral axonal neuropathy
HP:0003487	Babinski sign
HP:0003593	Infantile onset
HP:0003621	Juvenile onset
HP:0003677	Slowly progressive
HP:0006944	Abolished vibration sense
HP:0007021	Pain insensitivity
HP:0007340	Lower limb muscle weakness
HP:0010830	Impaired tactile sensation

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Enhanced
appendix	glandular cells	Low	Enhanced
breast	glandular cells	Low	Enhanced
bronchus	respiratory epithelial cells	Low	Enhanced
cerebellum	Purkinje cells	Medium	Enhanced
cerebellum	cells in granular layer	Medium	Enhanced
cerebral cortex	neuropil	Medium	Enhanced
cervix	glandular cells	Medium	Enhanced
colon	glandular cells	Low	Enhanced
colon	peripheral nerve/ganglion	Low	Enhanced
duodenum	glandular cells	Medium	Enhanced
fallopian tube	glandular cells	Low	Enhanced
heart muscle	cardiomyocytes	Low	Enhanced
kidney	cells in tubules	Medium	Enhanced
liver	hepatocytes	Low	Enhanced
lung	macrophages	Medium	Enhanced
ovary	follicle cells	Medium	Enhanced
pancreas	exocrine glandular cells	Medium	Enhanced
parathyroid gland	glandular cells	Medium	Enhanced
prostate	glandular cells	Low	Enhanced
rectum	glandular cells	Medium	Enhanced
salivary gland	glandular cells	Medium	Enhanced
seminal vesicle	glandular cells	Low	Enhanced
skin 1	Langerhans	Medium	Enhanced
skin 1	keratinocytes	Medium	Enhanced
small intestine	glandular cells	Medium	Enhanced
stomach 1	glandular cells	Medium	Enhanced
stomach 2	glandular cells	Medium	Enhanced
testis	Leydig cells	Low	Enhanced
testis	elongated or late spermatids	High	Enhanced
testis	pachytene spermatocytes	Low	Enhanced
testis	preleptotene spermatocytes	High	Enhanced
testis	round or early spermatids	High	Enhanced
testis	spermatogonia cells	High	Enhanced
thyroid gland	glandular cells	Low	Enhanced
tonsil	squamous epithelial cells	Medium	Enhanced
urinary bladder	urothelial cells	Low	Enhanced