Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0033211 | adiponectin-activated signaling pathway |
| Biological Process | GO:0007049 | cell cycle |
| Biological Process | GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| Biological Process | GO:0009631 | cold acclimation |
| Biological Process | GO:0002024 | diet induced thermogenesis |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:1900077 | negative regulation of cellular response to insulin stimulus |
| Biological Process | GO:1900016 | negative regulation of cytokine production involved in inflammatory response |
| Biological Process | GO:0046322 | negative regulation of fatty acid oxidation |
| Biological Process | GO:0046325 | negative regulation of glucose import |
| Biological Process | GO:2000178 | negative regulation of neural precursor cell proliferation |
| Biological Process | GO:0050768 | negative regulation of neurogenesis |
| Biological Process | GO:1905451 | positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:1905303 | positive regulation of macropinocytosis |
| Biological Process | GO:0060100 | positive regulation of phagocytosis, engulfment |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0010762 | regulation of fibroblast migration |
| Biological Process | GO:0045088 | regulation of innate immune response |
| Biological Process | GO:0034143 | regulation of toll-like receptor 4 signaling pathway |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0023052 | signaling |
| Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0032009 | early phagosome |
| Cellular Component | GO:0036186 | early phagosome membrane |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0044354 | macropinosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0032587 | ruffle membrane |
| Cellular Component | GO:0031982 | vesicle |
| InterPro
|
InterPro name |
|---|---|
| IPR001849 | Pleckstrin homology domain |
| IPR004148 | BAR domain |
| IPR006020 | PTB/PI domain |
| IPR011993 | PH-like domain superfamily |
| IPR027267 | AH/BAR domain superfamily |
| IPR047181 | DCC-interacting protein 13-alpha/beta |
| IPR047236 | DCC-interacting protein 13-alpha/beta, PH domain |
| IPR047237 | DCC-interacting protein 13-alpha/beta, PTB domain |
| IPR047239 | DCC-interacting protein 13-beta, BAR domain |
| Pfam
|
Pfam name |
|---|---|
| PF00169 | PH domain |
| PF00640 | Phosphotyrosine interaction domain (PTB/PID) |
| PF16746 | BAR domain of APPL family |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ECO:0000269 | PubMed:18034774 |
| Cell membrane | ECO:0000269 | |
| Cell projection, ruffle | ECO:0000250 | |
| Cell projection, ruffle membrane | ECO:0000250 | |
| Cytoplasm | ECO:0000250 | |
| Cytoplasmic vesicle, phagosome | ECO:0000250 | |
| Cytoplasmic vesicle, phagosome membrane | ECO:0000250 | |
| Early endosome membrane | ECO:0000269 | PubMed:15016378 |
| Endosome membrane | ECO:0000269 | PubMed:21645192 |
| Nucleus | ECO:0000269 | PubMed:15016378 |
| Nucleus | ECO:0000269 | PubMed:18034774 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebellum | cells in molecular layer | Low | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | High | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Medium | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | Low | Approved |
| kidney | cells in glomeruli | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells type I | Medium | Approved |
| lung | alveolar cells type II | High | Approved |
| lung | macrophages | High | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| ovary | follicle cells | Medium | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | High | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | High | Approved |
| skin 1 | melanocytes | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | chondrocytes | Low | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Medium | Approved |
| spleen | cells in red pulp | Low | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | High | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | non-germinal center cells | Low | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|