Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.6.1.52
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
diphosphoinositol-polyphosphate diphosphatase
3.6.1.60
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
diadenosine hexaphosphate hydrolase (AMP-forming)
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3MCF | 2.0 | Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:1901911 | adenosine 5'-(hexahydrogen pentaphosphate) catabolic process |
| Biological Process | GO:1901909 | diadenosine hexaphosphate catabolic process |
| Biological Process | GO:1901907 | diadenosine pentaphosphate catabolic process |
| Biological Process | GO:0071543 | diphosphoinositol polyphosphate metabolic process |
| Molecular Function | GO:0034431 | bis(5'-adenosyl)-hexaphosphatase activity |
| Molecular Function | GO:0034432 | bis(5'-adenosyl)-pentaphosphatase activity |
| Molecular Function | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity |
| Molecular Function | GO:0000298 | endopolyphosphatase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000305 | PubMed:12121577 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Low | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | adipocytes | Low | Approved |
| breast | glandular cells | Low | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebral cortex | neuronal cells | Low | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | glandular cells | Low | Approved |
| duodenum | glandular cells | Low | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Low | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Low | Approved |
| kidney | cells in tubules | Medium | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Low | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| ovary | follicle cells | Medium | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | decidual cells | Low | Approved |
| placenta | trophoblastic cells | Low | Approved |
| prostate | glandular cells | Low | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | Low | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| spleen | cells in red pulp | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Low | Approved |
| tonsil | non-germinal center cells | Low | Approved |
| tonsil | squamous epithelial cells | Low | Approved |
| urinary bladder | urothelial cells | Low | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|