MultifacetedProtDB - Bologna Biocomputing Group

Summary of Q8TAT5

Gene: NEIL3
Protein: Endonuclease 8-like 3

Protein family
Protein sequence
Protein function

Catalytic activity

EC number	EC number description
3.2.2.-	Hydrolases; Glycosylases; Hydrolysing N-glycosyl compounds;
4.2.99.18	Lyases; Carbon-oxygen lyases; Other carbon-oxygen lyases; DNA-(apurinic or apyrimidinic site) lyase

Publications

Structure

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006284	base-excision repair
Biological Process	GO:0006285	base-excision repair, AP site formation
Biological Process	GO:0045007	depurination
Biological Process	GO:0036297	interstrand cross-link repair
Molecular Function	GO:0019104	DNA N-glycosylase activity
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Function	GO:1904931	MCM complex binding
Molecular Function	GO:0000405	bubble DNA binding
Molecular Function	GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Function	GO:0003684	damaged DNA binding
Molecular Function	GO:0003690	double-stranded DNA binding
Molecular Function	GO:0003697	single-stranded DNA binding
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus

InterPro / Pfam

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110329	Cleavage of the damaged pyrimidine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected purine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110331	Cleavage of the damaged purine	Leaf	R-HSA-73894	DNA Repair
R-HSA-9629232	Defective Base Excision Repair Associated with NEIL3	Leaf	R-HSA-1643685	Disease
R-HSA-9636003	NEIL3-mediated resolution of ICLs	Leaf	R-HSA-73894	DNA Repair

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease