MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.3.16	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases; protein-serine/threonine phosphatase
3.1.3.48	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases; protein-tyrosine-phosphatase

PDB	Resolution (Å)	PDB name
3S4E	1.26	Crystal Structrue of a Novel Mitogen-activated Protein Kinase Phosphatase, SKRP1
4D3P	1.27	crystal structure of point mutated DUSP19 (C150A)
4D3Q	1.64	crystal structure of point mutated DUSP19 (R156A)
4D3R	1.67	Crystal structure of point mutated DUSP19 (I187A)

GO ontology	GO term	GO description
Biological Process	GO:0046329	negative regulation of JNK cascade
Biological Process	GO:0043508	negative regulation of JUN kinase activity
Biological Process	GO:0006469	negative regulation of protein kinase activity
Biological Process	GO:0046330	positive regulation of JNK cascade
Biological Process	GO:0043507	positive regulation of JUN kinase activity
Biological Process	GO:0043410	positive regulation of MAPK cascade
Biological Process	GO:0045860	positive regulation of protein kinase activity
Biological Process	GO:0006470	protein dephosphorylation
Biological Process	GO:0043405	regulation of MAP kinase activity
Molecular Function	GO:0008579	JUN kinase phosphatase activity
Molecular Function	GO:0005078	MAP-kinase scaffold activity
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding
Molecular Function	GO:0017018	myosin phosphatase activity
Molecular Function	GO:0030295	protein kinase activator activity
Molecular Function	GO:0004860	protein kinase inhibitor activity
Molecular Function	GO:0004725	protein tyrosine phosphatase activity
Molecular Function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
Cellular Component	GO:0005737	cytoplasm

InterPro	InterPro name
IPR000340	Dual specificity phosphatase, catalytic domain
IPR000387	Tyrosine-specific protein phosphatases domain
IPR020422	Dual specificity protein phosphatase domain
IPR029021	Protein-tyrosine phosphatase-like

Pfam	Pfam name
PF00782	Dual specificity phosphatase, catalytic domain

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Low	Approved
bronchus	respiratory epithelial cells	Medium	Approved
cerebral cortex	neuronal cells	Low	Approved
cervix	squamous epithelial cells	Medium	Approved
colon	glandular cells	High	Approved
colon	peripheral nerve/ganglion	Low	Approved
duodenum	glandular cells	High	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Medium	Approved
gallbladder	glandular cells	Medium	Approved
kidney	cells in tubules	High	Approved
liver	hepatocytes	Low	Approved
lymph node	germinal center cells	Low	Approved
lymph node	non-germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	Low	Approved
oral mucosa	squamous epithelial cells	Medium	Approved
pancreas	exocrine glandular cells	Medium	Approved
placenta	decidual cells	Medium	Approved
placenta	trophoblastic cells	Medium	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	High	Approved
small intestine	glandular cells	High	Approved
stomach 1	glandular cells	High	Approved
stomach 2	glandular cells	Low	Approved
testis	Leydig cells	Low	Approved
testis	cells in seminiferous ducts	Low	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Low	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	High	Approved
vagina	squamous epithelial cells	Low	Approved