MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.1.32	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; phospholipase A1
3.1.1.4	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; phospholipase A2

Structure

GO term

GO ontology	GO term	GO description
Biological Process	GO:0051792	medium-chain fatty acid biosynthetic process
Biological Process	GO:0051793	medium-chain fatty acid catabolic process
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process
Biological Process	GO:0046470	phosphatidylcholine metabolic process
Molecular Function	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Molecular Function	GO:0008126	acetylesterase activity
Molecular Function	GO:0047372	acylglycerol lipase activity
Molecular Function	GO:0052739	phosphatidylserine 1-acylhydrolase activity
Molecular Function	GO:0008970	phospholipase A1 activity
Molecular Function	GO:0004623	phospholipase A2 activity
Cellular Component	GO:0005886	plasma membrane

InterPro / Pfam

InterPro	InterPro name
IPR000073	Alpha/beta hydrolase fold-1
IPR000952	AB hydrolase 4, conserved site
IPR012020	AB hydrolase 4 family
IPR029058	Alpha/Beta hydrolase fold

Pfam	Pfam name
PF00561	alpha/beta hydrolase fold

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1483191	Synthesis of PC	Leaf	R-HSA-1430728	Metabolism

Subcellular location

Location	ECO term	Pubmed
Membrane	ECO:0000305

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Medium	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	glandular cells	High	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	glial cells	Medium	Approved
cerebral cortex	glial cells	Low	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	Medium	Approved
colon	glandular cells	Low	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	Low	Approved
fallopian tube	glandular cells	Low	Approved
gallbladder	glandular cells	Medium	Approved
hippocampus	glial cells	Low	Approved
kidney	cells in tubules	Medium	Approved
lung	alveolar cells type II	High	Approved
lymph node	germinal center cells	Low	Approved
lymph node	non-germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	Low	Approved
pancreas	exocrine glandular cells	Medium	Approved
pancreas	pancreatic endocrine cells	Low	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	decidual cells	Medium	Approved
rectum	glandular cells	Low	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Low	Approved
spleen	cells in red pulp	Medium	Approved
spleen	cells in white pulp	Low	Approved
stomach 1	glandular cells	Low	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Medium	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Medium	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	Medium	Approved

Summary of Q8WU67

Gene: ABHD3
Protein: Phospholipase ABHD3

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q8WU67

Gene: ABHD3 Protein: Phospholipase ABHD3

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: ABHD3
Protein: Phospholipase ABHD3