MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.3.1.-	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups;
2.3.1.48	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; histone acetyltransferase

Structure

PDB	Resolution (Å)	PDB name
1F68		NMR SOLUTION STRUCTURE OF THE BROMODOMAIN FROM HUMAN GCN5
1Z4R	1.74	Human GCN5 Acetyltransferase
3D7C	2.06	Crystal structure of the bromodomain of human GCN5, the general control of amino-acid synthesis protein 5-like 2
5H84	2.0	Human Gcn5 bound to propionyl-CoA
5H86	2.08	Human Gcn5 bound to butyryl-CoA
5MLJ	1.8	Bromodomain of Human GCN5 with 4-bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one
5TRL	2.299	Crystal structure of human GCN5 histone acetyltransferase domain
5TRM	2.9	Crystal structure of human GCN5 histone acetyltransferase domain
6J3P	1.598	Crystal structure of the human GCN5 bromodomain in complex with compound (R,R)-36n

GO term

GO ontology	GO term	GO description
Biological Process	GO:0071929	alpha-tubulin acetylation
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0048144	fibroblast proliferation
Biological Process	GO:0006094	gluconeogenesis
Biological Process	GO:0007507	heart development
Biological Process	GO:0043966	histone H3 acetylation
Biological Process	GO:0044154	histone H3-K14 acetylation
Biological Process	GO:0106077	histone succinylation
Biological Process	GO:0001701	in utero embryonic development
Biological Process	GO:0018393	internal peptidyl-lysine acetylation
Biological Process	GO:0048312	intracellular distribution of mitochondria
Biological Process	GO:0060173	limb development
Biological Process	GO:0007616	long-term memory
Biological Process	GO:0022037	metencephalon development
Biological Process	GO:0030901	midbrain development
Biological Process	GO:0035522	monoubiquitinated histone H2A deubiquitination
Biological Process	GO:0035521	monoubiquitinated histone deubiquitination
Biological Process	GO:0035264	multicellular organism growth
Biological Process	GO:0046600	negative regulation of centriole replication
Biological Process	GO:0045721	negative regulation of gluconeogenesis
Biological Process	GO:0001843	neural tube closure
Biological Process	GO:0106227	peptidyl-lysine glutarylation
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:2000727	positive regulation of cardiac muscle cell differentiation
Biological Process	GO:0031346	positive regulation of cell projection organization
Biological Process	GO:0001819	positive regulation of cytokine production
Biological Process	GO:0045722	positive regulation of gluconeogenesis
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0006282	regulation of DNA repair
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0043484	regulation of RNA splicing
Biological Process	GO:0050863	regulation of T cell activation
Biological Process	GO:1903010	regulation of bone development
Biological Process	GO:0061035	regulation of cartilage development
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0051302	regulation of cell division
Biological Process	GO:0045995	regulation of embryonic development
Biological Process	GO:0031063	regulation of histone deacetylation
Biological Process	GO:0031647	regulation of protein stability
Biological Process	GO:0045589	regulation of regulatory T cell differentiation
Biological Process	GO:2000036	regulation of stem cell population maintenance
Biological Process	GO:0048167	regulation of synaptic plasticity
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0090043	regulation of tubulin deacetylation
Biological Process	GO:0031667	response to nutrient levels
Biological Process	GO:0014070	response to organic cyclic compound
Biological Process	GO:0001756	somitogenesis
Biological Process	GO:0021537	telencephalon development
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0010484	histone H3 acetyltransferase activity
Molecular Function	GO:0043993	histone H3K18 acetyltransferase activity
Molecular Function	GO:0043992	histone H3K9 acetyltransferase activity
Molecular Function	GO:0043997	histone H4K12 acetyltransferase activity
Molecular Function	GO:0004402	histone acetyltransferase activity
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0106229	histone glutaryltransferase activity
Molecular Function	GO:0106078	histone succinyltransferase activity
Molecular Function	GO:0061733	peptide-lysine-N-acetyltransferase activity
Molecular Function	GO:0019903	protein phosphatase binding
Molecular Function	GO:0003713	transcription coactivator activity
Molecular Function	GO:0140416	transcription regulator inhibitor activity
Cellular Component	GO:0140672	ATAC complex
Cellular Component	GO:0000124	SAGA complex
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0000123	histone acetyltransferase complex
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0033276	transcription factor TFTC complex

InterPro / Pfam

InterPro	InterPro name
IPR000182	GNAT domain
IPR001487	Bromodomain
IPR009464	PCAF, N-terminal
IPR016181	Acyl-CoA N-acyltransferase
IPR016376	Histone acetyltransferase GCN5/PCAF
IPR018359	Bromodomain, conserved site
IPR036427	Bromodomain-like superfamily
IPR037800	Histone acetyltransferase GCN5

Pfam	Pfam name
PF00439	Bromodomain
PF00583	Acetyltransferase (GNAT) family
PF06466	PCAF (P300/CBP-associated factor) N-terminal domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1912408	Pre-NOTCH Transcription and Translation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-3214847	HATs acetylate histones	Leaf	R-HSA-4839726	Chromatin organization
R-HSA-350054	Notch-HLH transcription pathway	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-5689880	Ub-specific processing proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-73762	RNA Polymerase I Transcription Initiation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8941856	RUNX3 regulates NOTCH signaling	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9793380	Formation of paraxial mesoderm	Internal node	R-HSA-1266738	Developmental Biology

Location	ECO term	Pubmed
Chromosome	ECO:0000269	PubMed:29211711
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	ECO:0000269	PubMed:27796307
Nucleus	ECO:0000269	PubMed:11564863
Nucleus	ECO:0000269	PubMed:25593309
Nucleus	ECO:0000269	PubMed:27796307
Nucleus	ECO:0000269	PubMed:29211711

Summary of Q92830

Gene: KAT2A, GCN5, GCN5L2
Protein: Histone acetyltransferase KAT2A

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q92830

Gene: KAT2A, GCN5, GCN5L2 Protein: Histone acetyltransferase KAT2A

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: KAT2A, GCN5, GCN5L2
Protein: Histone acetyltransferase KAT2A