MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.3.1.48	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; histone acetyltransferase
2.3.1.57	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; diamine N-acetyltransferase

Structure

PDB	Resolution (Å)	PDB name
1CM0	2.3	CRYSTAL STRUCTURE OF THE PCAF/COENZYME-A COMPLEX
1JM4		NMR Structure of P/CAF Bromodomain in Complex with HIV-1 Tat Peptide
1N72		Structure and Ligand of a Histone Acetyltransferase Bromodomain
1WUG		complex structure of PCAF bromodomain with small chemical ligand NP1
1WUM		Complex structure of PCAF bromodomain with small chemical ligand NP2
1ZS5		Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association
2RNW		The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the Human Transcriptional Co-Activators PCAf and CBP
2RNX		The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the HUman Transcriptional Co-Activators PCAF and CBP
3GG3	2.25	Crystal Structure of the Bromodomain of Human PCAF
4NSQ	2.3108	Crystal structure of PCAF
5FDZ	2.4	Crystal structure of human PCAF bromodomain in complex with compound BDOMB00091a (compound 14)
5FE0	2.3	Crystal structure of human PCAF bromodomain in complex with acetyllysine
5FE1	2.22	Crystal structure of human PCAF bromodomain in complex with fragment BR004 (fragment 1)
5FE2	2.25	Crystal structure of human PCAF bromodomain in complex with fragment BR013 (fragment 3)
5FE3	2.12	Crystal structure of human PCAF bromodomain in complex with fragment MB360 (fragment 4)
5FE4	2.15	Crystal structure of human PCAF bromodomain in complex with fragment MB364 (fragment 5)
5FE5	2.12	Crystal structure of human PCAF bromodomain in complex with fragment MB093 (fragment 7)
5FE6	1.77	Crystal structure of human PCAF bromodomain in complex with fragment ZB1916 (fragment 10)
5FE7	2.08	Crystal structure of human PCAF bromodomain in complex with fragment ZB2216 (fragment 11)
5FE8	2.1	Crystal structure of human PCAF bromodomain in complex with compound SL1126 (compound 12)
5FE9	2.35	Crystal structure of human PCAF bromodomain in complex with compound SL1122 (compound 13)
5LVQ	2.05	Crystal structure of human PCAF bromodomain in complex with compound-D (CPD-D), N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide
5LVR	2.05	Crystal structure of human PCAF bromodomain in complex with compound-E (CPD-E)
5MKX	1.68	1.68A STRUCTURE PCAF BROMODOMAIN WITH 4-chloro-2-methyl-5-(methylamino)pyridazin-3(2H)-one
6J3O	2.11	Crystal structure of the human PCAF bromodomain in complex with compound 12

GO term

GO ontology	GO term	GO description
Biological Process	GO:0018076	N-terminal peptidyl-lysine acetylation
Biological Process	GO:0007049	cell cycle
Biological Process	GO:0032869	cellular response to insulin stimulus
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006094	gluconeogenesis
Biological Process	GO:0007507	heart development
Biological Process	GO:0043966	histone H3 acetylation
Biological Process	GO:0044154	histone H3-K14 acetylation
Biological Process	GO:0016573	histone acetylation
Biological Process	GO:0018393	internal peptidyl-lysine acetylation
Biological Process	GO:0060173	limb development
Biological Process	GO:0035522	monoubiquitinated histone H2A deubiquitination
Biological Process	GO:0035521	monoubiquitinated histone deubiquitination
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0046600	negative regulation of centriole replication
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process	GO:2000233	negative regulation of rRNA processing
Biological Process	GO:0018394	peptidyl-lysine acetylation
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore
Biological Process	GO:0045723	positive regulation of fatty acid biosynthetic process
Biological Process	GO:0045722	positive regulation of gluconeogenesis
Biological Process	GO:0045821	positive regulation of glycolytic process
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose
Biological Process	GO:0006473	protein acetylation
Biological Process	GO:0006282	regulation of DNA repair
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0043484	regulation of RNA splicing
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0051302	regulation of cell division
Biological Process	GO:0045995	regulation of embryonic development
Biological Process	GO:0031063	regulation of histone deacetylation
Biological Process	GO:0010835	regulation of protein ADP-ribosylation
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0090043	regulation of tubulin deacetylation
Biological Process	GO:0048511	rhythmic process
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function	GO:0016407	acetyltransferase activity
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
Molecular Function	GO:0004145	diamine N-acetyltransferase activity
Molecular Function	GO:0010484	histone H3 acetyltransferase activity
Molecular Function	GO:0043992	histone H3K9 acetyltransferase activity
Molecular Function	GO:0004402	histone acetyltransferase activity
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
Molecular Function	GO:0061733	peptide-lysine-N-acetyltransferase activity
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0003713	transcription coactivator activity
Molecular Function	GO:0003712	transcription coregulator activity
Molecular Function	GO:0140537	transcription regulator activator activity
Cellular Component	GO:0031672	A band
Cellular Component	GO:0140672	ATAC complex
Cellular Component	GO:0031674	I band
Cellular Component	GO:0000124	SAGA complex
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0000123	histone acetyltransferase complex
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex

InterPro / Pfam

InterPro	InterPro name
IPR000182	GNAT domain
IPR001487	Bromodomain
IPR009464	PCAF, N-terminal
IPR016181	Acyl-CoA N-acyltransferase
IPR016376	Histone acetyltransferase GCN5/PCAF
IPR018359	Bromodomain, conserved site
IPR036427	Bromodomain-like superfamily
IPR037800	Histone acetyltransferase GCN5

Pfam	Pfam name
PF00439	Bromodomain
PF00583	Acetyltransferase (GNAT) family
PF06466	PCAF (P300/CBP-associated factor) N-terminal domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1912408	Pre-NOTCH Transcription and Translation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-3214847	HATs acetylate histones	Leaf	R-HSA-4839726	Chromatin organization
R-HSA-350054	Notch-HLH transcription pathway	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-5578768	Physiological factors	Leaf	R-HSA-397014	Muscle contraction
R-HSA-5689901	Metalloprotease DUBs	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-73762	RNA Polymerase I Transcription Initiation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8941856	RUNX3 regulates NOTCH signaling	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9018519	Estrogen-dependent gene expression	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9617629	Regulation of FOXO transcriptional activity by acetylation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9793380	Formation of paraxial mesoderm	Internal node	R-HSA-1266738	Developmental Biology

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:20940255
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	ECO:0000269	PubMed:29174768
Nucleus	ECO:0000269	PubMed:20940255
Nucleus	ECO:0000269	PubMed:25593309
Nucleus	ECO:0000269	PubMed:29174768

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Supported
adrenal gland	glandular cells	Low	Supported
appendix	lymphoid tissue	Low	Supported
bone marrow	hematopoietic cells	Medium	Supported
breast	glandular cells	Low	Supported
breast	myoepithelial cells	Low	Supported
bronchus	respiratory epithelial cells	Medium	Supported
caudate	glial cells	Medium	Supported
caudate	neuronal cells	Medium	Supported
cerebellum	Purkinje cells	Medium	Supported
cerebellum	cells in granular layer	Low	Supported
cerebellum	cells in molecular layer	High	Supported
cerebral cortex	endothelial cells	Low	Supported
cerebral cortex	glial cells	Medium	Supported
cerebral cortex	neuronal cells	Medium	Supported
cerebral cortex	neuropil	Low	Supported
cervix	glandular cells	Low	Supported
cervix	squamous epithelial cells	Low	Supported
colon	endothelial cells	Low	Supported
colon	glandular cells	Medium	Supported
colon	peripheral nerve/ganglion	Low	Supported
duodenum	glandular cells	Medium	Supported
endometrium 1	glandular cells	Low	Supported
endometrium 2	glandular cells	Low	Supported
epididymis	glandular cells	Medium	Supported
esophagus	squamous epithelial cells	Low	Supported
fallopian tube	glandular cells	Medium	Supported
gallbladder	glandular cells	Medium	Supported
heart muscle	cardiomyocytes	Low	Supported
hippocampus	glial cells	Medium	Supported
hippocampus	neuronal cells	Low	Supported
kidney	cells in glomeruli	Medium	Supported
kidney	cells in tubules	Low	Supported
liver	hepatocytes	Low	Supported
lung	alveolar cells type I	Medium	Supported
lung	macrophages	Medium	Supported
lymph node	non-germinal center cells	Low	Supported
nasopharynx	respiratory epithelial cells	Medium	Supported
oral mucosa	squamous epithelial cells	Low	Supported
ovary	ovarian stroma cells	Medium	Supported
pancreas	exocrine glandular cells	Medium	Supported
pancreas	pancreatic endocrine cells	Medium	Supported
parathyroid gland	glandular cells	Medium	Supported
placenta	decidual cells	High	Supported
placenta	trophoblastic cells	High	Supported
prostate	glandular cells	Medium	Supported
rectum	glandular cells	Medium	Supported
salivary gland	glandular cells	High	Supported
seminal vesicle	glandular cells	Low	Supported
skeletal muscle	myocytes	Medium	Supported
skin 1	cells in granular layer	Low	Supported
skin 1	cells in spinous layer	Medium	Supported
skin 1	eccrine glands	Low	Supported
skin 1	endothelial cells	Low	Supported
skin 1	fibrohistiocytic cells	Medium	Supported
skin 1	langerhans cells	Medium	Supported
skin 1	lymphocytes	Medium	Supported
skin 1	melanocytes	High	Supported
skin 1	vascular mural cells	Low	Supported
skin 2	cells in granular layer	Medium	Supported
skin 2	cells in spinous layer	Medium	Supported
skin 2	endothelial cells	Low	Supported
skin 2	fibrohistiocytic cells	Medium	Supported
skin 2	langerhans cells	Medium	Supported
skin 2	lymphocytes	Medium	Supported
skin 2	melanocytes	High	Supported
small intestine	glandular cells	Medium	Supported
smooth muscle	smooth muscle cells	Low	Supported
soft tissue 2	fibroblasts	Medium	Supported
soft tissue 2	peripheral nerve	Low	Supported
spleen	cells in red pulp	Medium	Supported
stomach 1	glandular cells	High	Supported
stomach 2	glandular cells	Medium	Supported
testis	Leydig cells	Low	Supported
thyroid gland	glandular cells	High	Supported
tonsil	germinal center cells	Medium	Supported
tonsil	non-germinal center cells	Medium	Supported
tonsil	squamous epithelial cells	Low	Supported
urinary bladder	urothelial cells	High	Supported
vagina	squamous epithelial cells	Low	Supported

Summary of Q92831

Gene: KAT2B, PCAF
Protein: Histone acetyltransferase KAT2B

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q92831

Gene: KAT2B, PCAF Protein: Histone acetyltransferase KAT2B

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: KAT2B, PCAF
Protein: Histone acetyltransferase KAT2B